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Differences in the repair process of longitudinal and transverse injuries of cartilage in the rat knee.

Abstract：

OBJECTIVE:To clarify the relationship between type or direction of cartilage injury and its repair process, we investigated defects produced in rat knees histologically, immunohistochemically, and histomorphometrically. METHODS:A full-thickness cartilage injury (1 mm wide and 5 mm long) was produced on the patellar groove of one knee (L-injury) and transversely on the other knee (T-injury) in 42 male Wistar rats. Six rats each were sacrificed at 1, 2, 3, 4, 6 and 8 weeks after surgery, and cartilage tissues were obtained, prepared into 4 microns-thick histologic specimens, and stained with hematoxylin and eosin. Cartilage thickness, cartilage area, and surface roughness were measured using a computer system. Localization of S-100 proteins was evaluated with immunohistochemistry. RESULTS:Grossly, there were no difference in repair process between L- and T-injuries. However, histological and histomorphometric differences became apparent after the third week: cartilage thickness, repair area, and surface roughness showed better recovery in L-injury than in T-injury. Appearance of S-100-positive protein preceded the appearance of chondrocytes, and L-injury presented S-100 in the entire defect while S-100 in T-injury appeared mainly on the margins of the defect. CONCLUSIONS:Repair mechanisms of cartilage injury differs according to injury direction. Better repair can be obtained in the injury which is parallel to the direction of joint motion.

journal_name

Osteoarthritis Cartilage

journal_title

Osteoarthritis and cartilage

authors

Yoshioka M,Kubo T,Coutts RD,Hirasawa Y

doi

10.1053/joca.1997.0093

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

66-75

issue

1

eissn

1063-4584

issn

1522-9653

pii

S1063-4584(97)90093-5

journal_volume

6

pub_type

杂志文章

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