当前位置： SCI文献检索 > OSTEOARTHRITIS AND CARTILAGE期刊下所有文献 > Intra-articular sodium hyaluronate in osteoarthritis of the knee: a multicenter, double-blind study.

Intra-articular sodium hyaluronate in osteoarthritis of the knee: a multicenter, double-blind study.

Abstract：

:The efficacy and the safety of intra-articular injections of sodium hyaluronate were studied in patients with osteoarthritis of the knee in a randomized multicenter double-blind study. Two hundred and nine patients received five injections of either 25 mg hyaluronate/2.5 ml (verum, N = 102) or 0.25 mg hyaluronate/2.5 ml (control, N = 107) at weekly intervals. Seven patients in each group were excluded from the protocol-correct efficacy analysis. The Lequesne Index, the first main criterion, showed a significant superiority of the verum-treated patients after the third injection up to the final follow-up examination 9 weeks after the last injection (MANOVA, P < 0.025). The consumption of paracetamol was defined as a complementary main criterion that did not reveal significant differences between the treatment groups. Most of the individual secondary endpoints demonstrated a much better response to the active treatment without reaching the significance level in the intergroup comparisons for the single time-points. Side-effects were confined to local reactions of minor severity and short duration in four patients (six events) of the verum group and in five patients of the control group. Clinical chemistry and hematology remained essentially unchanged.

journal_name

Osteoarthritis Cartilage

journal_title

Osteoarthritis and cartilage

authors

Puhl W,Bernau A,Greiling H,Köpcke W,Pförringer W,Steck KJ,Zacher J,Scharf HP

doi

10.1016/s1063-4584(05)80329-2

keywords:

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

233-41

issue

4

eissn

1063-4584

issn

1522-9653

pii

S1063-4584(05)80329-2

journal_volume

1

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

相关文献

OSTEOARTHRITIS AND CARTILAGE文献大全
  • Prevalence of cam and pincer-type deformities on hip MRI in an asymptomatic young Swiss female population: a cross-sectional study.

    abstract：OBJECTIVES:Femoroacetabular impingement is proposed to cause early osteoarthritis (OA) in the non-dysplastic hip. We previously reported on the prevalence of femoral deformities in a young asymptomatic male population. The aim of this study was to determine the prevalence of both femoral and acetabular types of impinge...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2013.01.003

    authors： Leunig M,Jüni P,Werlen S,Limacher A,Nüesch E,Pfirrmann CW,Trelle S,Odermatt A,Hofstetter W,Ganz R,Reichenbach S

    更新日期：2013-04-01 00:00:00

  • Regulation of inflammatory and catabolic responses to IL-1β in rat articular chondrocytes by microRNAs miR-122 and miR-451.

    abstract：OBJECTIVE:miR-122 stimulates proliferation of growth plate chondrocytes whereas miR-451 stimulates terminal differentiation and matrix turnover. Here, we examined the potential of these microRNA as regulators of articular chondrocytes using an in vitro model of osteoarthritis. METHODS:miR-122 and miR-451 presence in r...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2020.09.004

    authors： Scott KM,Cohen DJ,Hays M,Nielson DW,Grinstaff MW,Lawson TB,Snyder BD,Boyan BD,Schwartz Z

    更新日期：2021-01-01 00:00:00

  • Association between smoking and risk of knee osteoarthritis: a systematic review and meta-analysis.

    abstract：OBJECTIVE:To investigate the association between smoking and the risk for knee osteoarthritis (OA). DESIGN:Cohort, case-control, and cross-sectional studies were obtained from the Medline, Embase, and Web of Science databases. Estimates were calculated using a random-effects model. Subgroup analyses and meta-regressio...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.joca.2016.12.020

    authors： Kong L,Wang L,Meng F,Cao J,Shen Y

    更新日期：2017-06-01 00:00:00

  • Validation of cartilage volume and thickness measurements in the human shoulder with quantitative magnetic resonance imaging.

    abstract：OBJECTIVE:To validate quantitative magnetic resonance imaging (qMRI) for the assessment of cartilage volume and thickness in thin and curved cartilage layers, such as the shoulder. METHODS:Eight shoulder specimens from healthy individuals (aged 31-69 years) were investigated using a 3D gradient echo sequence with sele...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/s1063-4584(03)00077-3

    authors： Graichen H,Jakob J,von Eisenhart-Rothe R,Englmeier KH,Reiser M,Eckstein F

    更新日期：2003-07-01 00:00:00

  • Predictors of moderate-severe functional limitation after primary Total Knee Arthroplasty (TKA): 4701 TKAs at 2-years and 2935 TKAs at 5-years.

    abstract：OBJECTIVE:Investigate whether body mass index (BMI), comorbidity, gender and age predict patient-reported functional limitation 2- and 5-years after primary Total Knee Arthroplasty (TKA). METHODS:Overall moderate-severe activity limitation was defined as > or = 2 activities (walking, stairs, rising from chair) with mo...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2009.12.001

    authors： Singh JA,O'Byrne M,Harmsen S,Lewallen D

    更新日期：2010-04-01 00:00:00

  • Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs.

    abstract：OBJECTIVE:To examine the effect of IL-1 beta-induced *NO and PGE(2)release by stimulated superficial and deep chondrocyte/agarose constructs subjected to mechanical compression. DESIGN:Chondrocyte sub-populations were seeded separately in agarose constructs and cultured unstrained, within a 24-well tissue culture plat...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/s1063-4584(03)00149-3

    authors： Chowdhury TT,Bader DL,Lee DA

    更新日期：2003-09-01 00:00:00

  • Evidence that human cartilage and chondrocytes do not express calcitonin receptor.

    abstract：OBJECTIVE:Calcitonin (CT) has been recently shown to exhibit direct protective effects on articular cartilage against joint degenerative disease. It has been proposed that CT might act via the CT receptor (CTR) to activate the cyclic AMP (cAMP) pathway and protect type II collagen degradation. In this study, we investi...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2007.08.003

    authors： Lin Z,Pavlos NJ,Cake MA,Wood DJ,Xu J,Zheng MH

    更新日期：2008-04-01 00:00:00

  • Fluorophore-assisted carbohydrate electrophoresis (FACE) of glycosaminoglycans.

    abstract：OBJECTIVE:Quantitation and analyses of the fine structure of glycosaminoglycans are increasingly important for understanding many biological processes, including those most critical for understanding skeletal biology. We have developed a novel procedure, fluorophore-assisted carbohydrate electrophoresis (FACE), for det...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1053/joca.2001.0439

    authors： Calabro A,Midura R,Wang A,West L,Plaas A,Hascall VC

    更新日期：2001-01-01 00:00:00

  • Multimodality scoring of chondral injuries in the equine fetlock joint ex vivo.

    abstract：OBJECTIVE:We investigate the potential of a prototype multimodality arthroscope, combining ultrasound, optical coherence tomography (OCT) and arthroscopic indentation device, for assessing cartilage lesions, and compare the reliability of this approach with conventional arthroscopic scoring ex vivo. DESIGN:Areas of in...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2016.12.007

    authors： Sarin JK,Brommer H,Argüelles D,Puhakka PH,Inkinen SI,Afara IO,Saarakkala S,Töyräs J

    更新日期：2017-05-01 00:00:00

  • Exercise-driven metabolic pathways in healthy cartilage.

    abstract：OBJECTIVE:Exercise is vital for maintaining cartilage integrity in healthy joints. Here we examined the exercise-driven transcriptional regulation of genes in healthy rat articular cartilage to dissect the metabolic pathways responsible for the potential benefits of exercise. METHODS:Transcriptome-wide gene expression...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2016.02.004

    authors： Blazek AD,Nam J,Gupta R,Pradhan M,Perera P,Weisleder NL,Hewett TE,Chaudhari AM,Lee BS,Leblebicioglu B,Butterfield TA,Agarwal S

    更新日期：2016-07-01 00:00:00

  • The Bristol 'OA500' study: progression of osteoarthritis (OA) over 3 years and the relationship between clinical and radiographic changes at the knee joint.

    abstract：:Five hundred patients with established, symptomatic limb joint OA have been recruited into an on-going prospective study of the natural history of the condition. Four hundred and fifteen patients (mean age 65.6 years, female to male ratio 2.05:1) were available for a full clinical and radiographic review 3 years after...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/s1063-4584(97)80002-7

    authors： Dieppe PA,Cushnaghan J,Shepstone L

    更新日期：1997-03-01 00:00:00

  • Comparative evaluation of three semi-quantitative radiographic grading techniques for hip osteoarthritis in terms of validity and reproducibility in 1404 radiographs: report of the OARSI-OMERACT Task Force.

    abstract：OBJECTIVE:The objective of this work was to compare the measurement properties of three categorical X-ray scoring methods for hip osteoarthritis (OA). METHODS:In data obtained from trials and cohorts, radiographs were evaluated using the Kellgren and Lawrence (KL) grading system, the Osteoarthritis Research Society In...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2008.06.009

    authors： Gossec L,Jordan JM,Lam MA,Fang F,Renner JB,Davis A,Hawker GA,Dougados M,Maillefert JF,OARSI-OMERACT task force \total articular replacement as outcome measure in OA\.

    更新日期：2009-02-01 00:00:00

  • Tumor risk by tissue engineering: cartilaginous differentiation of mesenchymal stem cells reduces tumor growth.

    abstract：OBJECTIVE:Implantation of autologous chondrocytes (AC) is a promising option for the treatment of cartilage defects, but problems with cell harvesting, dedifferentiation, or the donor age limit the clinical outcome. Mesenchymal stem cells (MSC) gain much interest because of their simple isolation and multipotential dif...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2009.10.015

    authors： Akay I,Oxmann D,Helfenstein A,Mentlein R,Schünke M,Hassenpflug J,Kurz B

    更新日期：2010-03-01 00:00:00

  • Osteoarthritis of the knee after meniscal resection: long term radiographic evaluation of disease progression.

    abstract：OBJECTIVE:To determine prevalence, incidence and progression of radiographic knee osteoarthritis (OA) in a cohort of subjects with previous meniscectomy. METHODS:We assessed 221 subjects (177 men and 44 women) with weight bearing knee radiography twice (assessment A and B) with a follow-up time ranging from 4 to 10 ye...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2015.12.002

    authors： Paradowski PT,Lohmander LS,Englund M

    更新日期：2016-05-01 00:00:00

  • Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) is closely associated with the chondrocyte nucleus in human articular cartilage.

    abstract：OBJECTIVE:Insulin-like growth factor-I (IGF-I) is critically involved in the control of cartilage matrix metabolism. It is well known that IGF-binding protein-3 (IGFBP-3) is increased during osteoarthritis (OA), but its function(s) is not known. In other cells, IGFBP-3 can regulate IGF-I action in the extracellular env...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2007.06.008

    authors： Hunziker EB,Kapfinger E,Martin J,Buckwalter J,Morales TI

    更新日期：2008-02-01 00:00:00

  • An MRI derived articular cartilage visualization framework.

    abstract：OBJECTIVE:We present a multi-dimensional framework for the visualization of femoral articular cartilage. The framework comprises methods for visualizing and quantifying changes in cartilage thickness and surface morphology derived from MRI based cartilage segmentation. Adequate visualization of cartilage allows accurat...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2007.03.009

    authors： Akhtar S,Poh CL,Kitney RI

    更新日期：2007-09-01 00:00:00

  • Histopathology atlas of animal model systems - overview of guiding principles.

    abstract：:Animal model systems represent an important adjunct and surrogate for studies of osteoarthritis (OA) in humans. They provide a means to study OA pathophysiology as well as aid in the development of therapeutic agents and biological markers for diagnosing and prognosing the disease. Thus, it is of great importance for ...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2010.07.013

    authors： Aigner T,Cook JL,Gerwin N,Glasson SS,Laverty S,Little CB,McIlwraith W,Kraus VB

    更新日期：2010-10-01 00:00:00

  • Cartilage degeneration in the goat knee caused by treating localized cartilage defects with metal implants.

    abstract：OBJECTIVE:The purpose of the current study was to investigate the feasibility of applying defect-size femoral implants for the treatment of localized cartilage defects in a 1-year follow-up model. METHODS:In 13 goats, a medial femoral condyle defect was created in both knees. Defects were randomly treated by immediate...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2009.10.009

    authors： Custers RJ,Dhert WJ,Saris DB,Verbout AJ,van Rijen MH,Mastbergen SC,Lafeber FP,Creemers LB

    更新日期：2010-03-01 00:00:00

  • The chondrogenic potential of carbon fiber and carbon fiber periosteum implants: an ultrastructural study in the rabbit.

    abstract：:The articular tissue generated on carbon fiber rods in rabbit knee joints after 75 days of intermittent active motion was compared with tissue generated on carbon fiber rods whose articular surfaces were covered with a free reversed periosteal graft. Both methods were effective in generating articular tissue; however,...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/s1063-4584(05)80077-9

    authors： Curtin W,Reville W,Heapes M,Lyons J,Muckle D

    更新日期：1994-12-01 00:00:00

  • Interaction between zonal populations of articular chondrocytes suppresses chondrocyte mineralization and this process is mediated by PTHrP.

    abstract：OBJECTIVE:Articular cartilage is separated from subchondral bone by the tidemark and a calcified cartilage zone. Advancement of the calcified region and tidemark duplication are both hallmarks of osteoarthritis (OA). Currently the mechanisms controlling post-natal articular cartilage mineralization are poorly understoo...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2007.05.014

    authors： Jiang J,Leong NL,Mung JC,Hidaka C,Lu HH

    更新日期：2008-01-01 00:00:00

  • A positive association of smoking and articular knee joint cartilage in healthy people.

    abstract：OBJECTIVE:To determine whether smoking affects knee cartilage in healthy adults by examining the association of tobacco use with tibial cartilage volume and tibiofemoral cartilage defects. METHODS:Two hundred and ninety-seven healthy adult subjects were recruited from an existing cohort examining healthy aging, the Me...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2006.12.005

    authors： Racunica TL,Szramka M,Wluka AE,Wang Y,English DR,Giles GG,O'Sullivan R,Cicuttini FM

    更新日期：2007-05-01 00:00:00

  • Long-term clinical and economic outcomes of a short-term physical activity program in knee osteoarthritis patients.

    abstract：OBJECTIVE:Physical activity (PA) in the US knee osteoarthritis (OA) population is low, despite well-established health benefits. PA program implementation is often stymied by sustainability concerns. We sought to establish parameters that would make a short-term (3-year efficacy) PA program a cost-effective component o...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2020.01.017

    authors： Silva GS,Sullivan JK,Katz JN,Messier SP,Hunter DJ,Losina E

    更新日期：2020-06-01 00:00:00

  • Role of thigh muscle cross-sectional area and strength in progression of knee cartilage degeneration over 48 months - data from the Osteoarthritis Initiative.

    abstract：OBJECTIVE:To determine in a 48-month longitudinal study the association of thigh muscle cross-sectional area (CSA) and strength on progression of morphologic knee cartilage degeneration using 3T magnetic resonance imaging (MRI). DESIGN:Seventy Osteoarthritis Initiative (OAI) subjects aged 50-60 years, with no radiogra...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2016.07.004

    authors： Goldman LH,Tang K,Facchetti L,Heilmeier U,Joseph GB,Nevitt MC,McCulloch CE,Souza RB,Link TM

    更新日期：2016-12-01 00:00:00

  • A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis.

    abstract：OBJECTIVE:To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity. METHODS:Standard search strategies for population-based studies of OA providing sex-specific data. Random effects meta-analysis to provide pooled ...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.joca.2005.04.014

    authors： Srikanth VK,Fryer JL,Zhai G,Winzenberg TM,Hosmer D,Jones G

    更新日期：2005-09-01 00:00:00

  • Mechanism of proteoglycan aggregate degradation in cartilage stimulated with oncostatin M.

    abstract：OBJECTIVE:To investigate the potential synergistic and differential effects of cytokine combinations on proteoglycan aggregate catabolism in cartilage. METHODS:Bovine articular cartilage explants were maintained in organ culture and subjected to stimulation with cytokine combinations including interleukin-1alpha (IL-1...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2007.05.002

    authors： Durigova M,Roughley PJ,Mort JS

    更新日期：2008-01-01 00:00:00

  • Nondestructive assessment of sGAG content and distribution in normal and degraded rat articular cartilage via EPIC-microCT.

    abstract：OBJECTIVE:The objective of this study was to evaluate the feasibility of quantifying the Equilibrium Partitioning of an Ionic Contrast agent via Microcomputed Tomography (EPIC-microCT) to nondestructively assess sulfated glycosaminoglycan (sGAG) content and distribution in rat articular cartilage ex vivo, and in doing ...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2009.07.014

    authors： Xie L,Lin AS,Guldberg RE,Levenston ME

    更新日期：2010-01-01 00:00:00

  • Occupational risk factors for osteoarthritis of the knee: a meta-analysis.

    abstract：INTRODUCTION:Systematic reviews agree that knee osteoarthritis (OA) is related to occupational activities, but have not quantified the overall risks. METHODS:Systematic review of observational studies of knee OA and occupation. Job titles, elite sport, heavy work, kneeling, and other activities were included. Relative...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.joca.2011.02.016

    authors： McWilliams DF,Leeb BF,Muthuri SG,Doherty M,Zhang W

    更新日期：2011-07-01 00:00:00

  • A randomized trial of patellofemoral bracing for treatment of patellofemoral osteoarthritis.

    abstract：PURPOSE:The number of effective knee osteoarthritis (OA) interventions, especially those tailored to specific compartmental involvement, are small. The objective of this study was to determine the efficacy of a realigning patellofemoral (PF) brace in improving pain and function among persons with symptomatic lateral PF...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.joca.2010.12.010

    authors： Hunter DJ,Harvey W,Gross KD,Felson D,McCree P,Li L,Hirko K,Zhang B,Bennell K

    更新日期：2011-07-01 00:00:00

  • Overexpression of secretory leukocyte peptidase inhibitor (SLPI) does not modulate experimental osteoarthritis but may be a biomarker for the disease.

    abstract：OBJECTIVE:Osteoarthritic cartilage destruction can be regulated by the balance between proteases and anti-proteases. Here, we sought to identify novel cellular protease inhibitors associated with osteoarthritis (OA) pathogenesis. METHODS:Candidate molecules were screened from microarray data of chondrocytes treated wi...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2021.01.003

    authors： Kim HE,Shin Y,Jung IJ,Yang JI,Chun CH,Kim HA,Chun JS

    更新日期：2021-01-21 00:00:00

  • Aging does not change the compressive stiffness of mandibular condylar cartilage in horses.

    abstract：OBJECTIVE:Aging can cause an increase in the stiffness of hyaline cartilage as a consequence of increased protein crosslinks. By induction of crosslinking, a reduction in the diffusion of solutions into the hyaline cartilage has been observed. However, there is a lack of knowledge about the effects of aging on the biop...

    journal_title：Osteoarthritis and cartilage

    pub_type： 杂志文章

    doi：10.1016/j.joca.2018.08.007

    authors： Mirahmadi F,Koolstra JH,Fazaeli S,Lobbezoo F,van Lenthe GH,Snabel J,Stoop R,Arbabi V,Weinans H,Everts V

    更新日期：2018-12-01 00:00:00