PlanMine--a mineable resource of planarian biology and biodiversity.

abstract：:A 12 bp long GCN4-binding, self-complementary duplex DNA d(CATGACGTCATG)(2) has been investigated by NMR spectroscopy to study the structure and dynamics of the molecule in aqueous solution. The NMR structure of the DNA obtained using simulated annealing and iterative relaxation matrix calculations compares quite clos...

journal_title：Nucleic acids research

authors： Khandelwal P,Panchal SC,Radha PK,Hosur RV

更新日期：2001-01-15 00:00:00

abstract：:Ribosome biogenesis in Saccharomyces cerevisiae involves a regulon of >200 genes (Ribi genes) coordinately regulated in response to nutrient availability and cellular growth rate. Two cis-acting elements called PAC and RRPE are known to mediate Ribi gene repression in response to nutritional downshift. Here, we show t...

journal_title：Nucleic acids research

authors： Bosio MC,Fermi B,Spagnoli G,Levati E,Rubbi L,Ferrari R,Pellegrini M,Dieci G

更新日期：2017-05-05 00:00:00

abstract：:Intrinsic energetic and solvation factors contributing to the unusual structural and biochemical properties of N3'-phosphoramidate DNA analogs have been re-examined using a combination of quantum mechanical and molecular dynamics methods. Evaluation of the impact of the N3'-H substitution was performed via comparison ...

journal_title：Nucleic acids research

authors： Banavali NK,MacKerell AD

更新日期：2001-08-01 00:00:00

abstract：:A multipurpose plasmid, pUR 250, has been constructed. It contains seven unique cloning sites (Hind III, Xba I, Sal I, Acc I, Hinc II, BamH I and EcoR I) in a small region of its lac Z gene part. Insertion of foreign DNA into the plasmid can be easily detected. Plasmid DNA isolated from a clone by a rapid method can b...

journal_title：Nucleic acids research

authors： Rüther U

更新日期：1982-10-11 00:00:00

abstract：:Intron retention (IR) has been proposed to modulate the delay between transcription and translation. Here, we provide an exhaustive characterization of IR in differentiated white blood cells from both the myeloid and lymphoid lineage where we observed highest levels of IR in monocytes and B-cells, in addition to previ...

journal_title：Nucleic acids research

authors： Ullrich S,Guigó R

更新日期：2020-02-20 00:00:00

abstract：:We devised an indicator gene for retrotransposition based on an autocatalytic ribozyme element--the Tetrahymena thermophila 23S rRNA group I intron--which can self-splice in vitro and does not require--at variance with nuclear mRNA introns--any specific pathway and cellular component for the completion of the splicing...

journal_title：Nucleic acids research

authors： Esnault C,Casella JF,Heidmann T

更新日期：2002-06-01 00:00:00

abstract：:We analysed the basic mechanisms of signal transmission in DNA and the origins of the allostery exhibited by systems such as the ternary complex BAMHI-DNA-GRDBD. We found that perturbation information generated by a primary protein binding event travels as a wave to distant regions of DNA following a hopping mechanism...

journal_title：Nucleic acids research

authors： Balaceanu A,Pérez A,Dans PD,Orozco M

更新日期：2018-09-06 00:00:00

abstract：:Human MitBASE is a database collecting human mtDNA variants. This database is part of a greater mitochondrial genome database (MitBASE) funded within the EU Biotech Program. The present paper reports the recent improvements in data structure, data quality and data quantity. As far as the database structure is concerne...

journal_title：Nucleic acids research

authors： Attimonelli M,Cooper JM,D'Elia D,de Montalvo A,De Robertis M,Lehväslaiho H,Malladi SB,Memeo F,Stevens K,Schapira AH,Saccone C

更新日期：1999-01-01 00:00:00

abstract：:Two different genomic genes for the COUP-transcription factor, COUP-TF I and COUP-TF II, have been isolated from a human cosmid genomic library using a [32P]-labeled cDNA probe. Data obtained from Southern blot analysis of these cosmid clones indicated that two closely related genes exist in the human genome and have ...

journal_title：Nucleic acids research

authors： Ritchie HH,Wang LH,Tsai S,O'Malley BW,Tsai MJ

更新日期：1990-12-11 00:00:00

abstract：:Protein-based methods of siRNA delivery are capable of uniquely specific targeting, but are limited by technical challenges such as low potency or poor biophysical properties. Here, we engineered a series of ultra-high affinity siRNA binders based on the viral protein p19 and developed them into siRNA carriers targete...

journal_title：Nucleic acids research

authors： Yang NJ,Kauke MJ,Sun F,Yang LF,Maass KF,Traxlmayr MW,Yu Y,Xu Y,Langer RS,Anderson DG,Wittrup KD

更新日期：2017-07-27 00:00:00

abstract：:In most eukaryotes, genetic exchange between paired homologs occurs in the context of a tripartite proteinaceous structure called the synaptonemal complex (SC). Genetic analyses have revealed that the genes encoding SC proteins are vital for meiotic chromosome pairing and recombination. However, the number, nature and...

journal_title：Nucleic acids research

authors： Anuradha S,Muniyappa K

更新日期：2004-04-28 00:00:00

abstract：:We present a theory of pluralistic and stochastic gene regulation. To bridge the gap between empirical studies and mathematical models, we integrate pre-existing observations with our meta-analyses of the ENCODE ChIP-Seq experiments. Earlier evidence includes fluctuations in levels, location, activity, and binding of ...

journal_title：Nucleic acids research

authors： Salas EN,Shu J,Cserhati MF,Weeks DP,Ladunga I

更新日期：2016-06-02 00:00:00

abstract：:Molecules of single-stranded ribosomal RNA and double-stranded replicative form of phage f2 RNA (dsRNA) adopt a compact form in solutions, containing sufficiently high concentrations of salt (NaCl) and polymer (PEG). However, only in the cases of native dsRNA molecules the compact particles are characterized by a regu...

journal_title：Nucleic acids research

authors： Evdokimov YM,Pyatigorskaya TL,Kadikov VA,Polyvtsev OF,Doskocil J,Koudelka J,Varshavsky YM

更新日期：1976-06-01 00:00:00

abstract：:Plant mitochondrial genomes show much more evolutionary plasticity than those of animals. We analysed the first mitochondrial DNA (mtDNA) of a lycophyte, the quillwort Isoetes engelmannii, which is separated from seed plants by more than 350 million years of evolution. The Isoetes mtDNA is particularly rich in recombi...

journal_title：Nucleic acids research

authors： Grewe F,Viehoever P,Weisshaar B,Knoop V

更新日期：2009-08-01 00:00:00

abstract：:During the formation of a transcriptionally active macronucleus, ciliated protozoa excise large numbers of interstitial segments of DNA (internal eliminated sequences; IESs) from their chromosomes. In this study we analyze the published sequences of 20 IESs that interrupt surface protein genes of Paramecium and identi...

journal_title：Nucleic acids research

authors： Klobutcher LA,Herrick G

更新日期：1995-06-11 00:00:00

abstract：:The histone variant H2A.Z has been implicated in many biological processes, such as gene regulation and genome stability. Here, we present the identification of H2A.Z.2.2 (Z.2.2), a novel alternatively spliced variant of histone H2A.Z and provide a comprehensive characterization of its expression and chromatin incorpo...

journal_title：Nucleic acids research

authors： Bönisch C,Schneider K,Pünzeler S,Wiedemann SM,Bielmeier C,Bocola M,Eberl HC,Kuegel W,Neumann J,Kremmer E,Leonhardt H,Mann M,Michaelis J,Schermelleh L,Hake SB

更新日期：2012-07-01 00:00:00

abstract：:A specific segment of mitochondrial DNA from 18 people was examined by two methods of direct DNA sequencing. This segment includes a small noncoding region (V) shown before by restriction analysis to exhibit length polymorphism. All 11 of the human mtDNAs previously reported to have a deletion in this region proved to...

journal_title：Nucleic acids research

authors： Wrischnik LA,Higuchi RG,Stoneking M,Erlich HA,Arnheim N,Wilson AC

更新日期：1987-01-26 00:00:00

abstract：:The repetitive zinc finger domain of transcription factor IIIA binds 5S DNA and 5S RNA with similar affinity. Site directed mutagenesis of the Xenopus borealis somatic 5S RNA gene has been used to produce a series of derivatives of 5S RNA containing local sequence substitutions or sequence deletions. Gel mobility shif...

journal_title：Nucleic acids research

authors： Bogenhagen DF,Sands MS

更新日期：1992-06-11 00:00:00

abstract：:Post-synthetic enzymatic hypermethylation of DNA was induced in hamster fibrosarcoma cells by the DNA synthesis inhibitors cytosine arabinoside, hydroxyurea and aphidicolin. This effect required direct inhibition of DNA polymerase alpha or reduction in deoxynucleotide pools and was not specific to a single cell type. ...

journal_title：Nucleic acids research

authors： Nyce J,Liu L,Jones PA

更新日期：1986-05-27 00:00:00

abstract：:N7-Methyl-2'-deoxyguanosine (m7dG) is the predominant lesion formed by methylating agents. A systematic investigation on the effect of m7dG on DNA replication has been difficult due to the chemical instability of m7dG. To gain insights into the m7dG effect, we employed a 2'-fluorine-mediated transition-state destabilz...

journal_title：Nucleic acids research

authors： Koag MC,Kou Y,Ouzon-Shubeita H,Lee S

更新日期：2014-07-01 00:00:00

abstract：:Six 1',5'-anhydrohexitol uridine triphosphates were synthesized with aromatic substitutions appended via a carboxamide linker to the 5-position of their bases. An improved method for obtaining such 5-substituted hexitol nucleosides and nucleotides is described. The incorporation profile of the nucleotide analogues int...

journal_title：Nucleic acids research

authors： Renders M,Dumbre S,Abramov M,Kestemont D,Margamuljana L,Largy E,Cozens C,Vandenameele J,Pinheiro VB,Toye D,Frère JM,Herdewijn P

更新日期：2019-03-18 00:00:00

abstract：:Revealing the clonal composition of a single tumor is essential for identifying cell subpopulations with metastatic potential in primary tumors or with resistance to therapies in metastatic tumors. Sequencing technologies provide only an overview of the aggregate of numerous cells. Computational approaches to de-mix a...

journal_title：Nucleic acids research

authors： Strino F,Parisi F,Micsinai M,Kluger Y

更新日期：2013-09-01 00:00:00

abstract：:The Bovine Genome Database (BGD) (http://bovinegenome.org) has been the key community bovine genomics database for more than a decade. To accommodate the increasing amount and complexity of bovine genomics data, BGD continues to advance its practices in data acquisition, curation, integration and efficient data retrie...

journal_title：Nucleic acids research

authors： Shamimuzzaman M,Le Tourneau JJ,Unni DR,Diesh CM,Triant DA,Walsh AT,Tayal A,Conant GC,Hagen DE,Elsik CG

更新日期：2020-01-08 00:00:00

abstract：:2'-O-(2-methoxyethyl) (2'-MOE) RNA possesses favorable pharmocokinetic properties that make it a promising option for the design of oligonucleotide drugs. Telomerase is a ribonucleoprotein that is up-regulated in many types of cancer, but its potential as a target for chemotherapy awaits the development of potent and ...

journal_title：Nucleic acids research

authors： Elayadi AN,Demieville A,Wancewicz EV,Monia BP,Corey DR

更新日期：2001-04-15 00:00:00

abstract：:T1DBase (http://www.t1dbase.org) is web platform, which supports the type 1 diabetes (T1D) community. It integrates genetic, genomic and expression data relevant to T1D research across mouse, rat and human and presents this to the user as a set of web pages and tools. This update describes the incorporation of new dat...

journal_title：Nucleic acids research

authors： Burren OS,Adlem EC,Achuthan P,Christensen M,Coulson RM,Todd JA

更新日期：2011-01-01 00:00:00

abstract：:Mutations in mammalian and Drosophila Hel308 and PolQ paralogues cause genome instability but their helicase functions are mysterious. By in vivo and in vitro analysis, we show that Hel308 from archaea (Hel308a) may act at stalled replication forks. Introducing hel308a into Escherichia coli dnaE strains that condition...

journal_title：Nucleic acids research

authors： Guy CP,Bolt EL

更新日期：2005-06-30 00:00:00

abstract：:Small inverted repeats (small palindromes) on plasmids have been shown to mediate a recombinational rearrangement event in Escherichia coli leading to the formation of inverted dimers (giant palindromes). This recombinational rearrangement event is efficient and independent of RecA and RecBCD. In this report, we propo...

journal_title：Nucleic acids research

authors： Lin CT,Lyu YL,Liu LF

更新日期：1997-08-01 00:00:00

abstract：:The solubility of adult beta-globin chromatin (beta A chromatin) from immature chicken red blood cells can be controlled by the presence or absence of n-butyrate in a cell incubation medium. In the absence of n-butyrate, only a small percentage (approximately 4%) of the total beta A chromatin is in a soluble chromatin...

journal_title：Nucleic acids research

authors： Ferenz CR,Nelson DA

更新日期：1985-03-25 00:00:00

abstract：:We have exploited properties of photosensitizers to study an aspect of the packing of chromatin in the cell nucleus. The fluorescent photosensitizers mesotetra(3-hydroxyphenyl) porphyrin and Photofrin II were both localized in the nuclear membrane and other membrane structures, but could not be found inside the nuclei...

journal_title：Nucleic acids research

authors： Kvam E,Stokke T,Moan J,Steen HB

更新日期：1992-12-25 00:00:00

abstract：:Initiation of reverse transcription is a complex and regulated process in all retroviruses. Several base pairing interactions have been proposed to occur between the HIV-1 RNA genome and the specific tRNA(lys3) primer. The tRNA primer can form up to 21 bp with the primer binding site (PBS), and an additional 8 bp inte...

journal_title：Nucleic acids research

authors： Huthoff H,Bugala K,Barciszewski J,Berkhout B

更新日期：2003-09-01 00:00:00