PDZ-Reactive Peptide Activates Ephrin-B Reverse Signaling and Inhibits Neuronal Chemotaxis.


:Intracellular reactions on nonenzymatic proteins that activate cellular signals are rarely found. We report one example here that a designed peptide derivative undergoes a nucleophilic reaction specifically with a cytosolic PDZ protein inside cells. This reaction led to the activation of ephrin-B reverse signaling, which subsequently inhibited SDF-1 induced neuronal chemotaxis of human neuroblastoma cells and mouse cerebellar granule neurons. Our work provides direct evidence that PDZ-RGS3 bridges ephrin-B reverse signaling and SDF-1 induced G protein signaling for the first time.


ACS Chem Biol


ACS chemical biology


Yu Y,Liu M,Ng TT,Huang F,Nie Y,Wang R,Yao ZP,Li Z,Xia J




Has Abstract


2016-01-15 00:00:00












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    authors: Liljeruhm J,Wang J,Kwiatkowski M,Sabari S,Forster AC

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    authors: Buer BC,Paul B,Das D,Stuckey JA,Marsh EN

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  • Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy.

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    pub_type: 杂志文章


    authors: Takayama K,Mizuguchi H

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    pub_type: 杂志文章


    authors: Pouilly S,Bourgeaux V,Piller F,Piller V

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    pub_type: 杂志文章


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    authors: Karlsson AJ,Pomerantz WC,Neilsen KJ,Gellman SH,Palecek SP

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    authors: Marcheschi RJ,Li H,Zhang K,Noey EL,Kim S,Chaubey A,Houk KN,Liao JC

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    authors: Rinaldi S,Assimon VA,Young ZT,Morra G,Shao H,Taylor IR,Gestwicki JE,Colombo G

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    authors: Dixon AS,Schwinn MK,Hall MP,Zimmerman K,Otto P,Lubben TH,Butler BL,Binkowski BF,Machleidt T,Kirkland TA,Wood MG,Eggers CT,Encell LP,Wood KV

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    authors: Tomita T,Kim SY,Teramoto K,Meguro A,Ozaki T,Yoshida A,Motoyoshi Y,Mori N,Ishigami K,Watanabe H,Nishiyama M,Kuzuyama T

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    journal_title:ACS chemical biology

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    journal_title:ACS chemical biology

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    authors: Komarov AG,Linn KM,Devereaux JJ,Valiyaveetil FI

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    authors: Zhou S,Song L,Masschelein J,Sumang FAM,Papa IA,Zulaybar TO,Custodio AB,Zabala D,Alcantara EP,de Los Santos ELC,Challis GL

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    journal_title:ACS chemical biology

    pub_type: 杂志文章


    authors: Zhang HM,Dai H,Hanson PJ,Li H,Guo H,Ye X,Hemida MG,Wang L,Tong Y,Qiu Y,Liu S,Wang F,Song F,Zhang B,Wang JG,Zhang LX,Yang D

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    journal_title:ACS chemical biology

    pub_type: 杂志文章


    authors: Koch A,Rode HB,Richters A,Rauh D,Hauf S

    更新日期:2012-04-20 00:00:00

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    journal_title:ACS chemical biology

    pub_type: 杂志文章


    authors: Charoenwattanasatien R,Pengthaisong S,Breen I,Mutoh R,Sansenya S,Hua Y,Tankrathok A,Wu L,Songsiriritthigul C,Tanaka H,Williams SJ,Davies GJ,Kurisu G,Cairns JR

    更新日期:2016-07-15 00:00:00

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    journal_title:ACS chemical biology

    pub_type: 杂志文章


    authors: Morton LA,Yang H,Saludes JP,Fiorini Z,Beninson L,Chapman ER,Fleshner M,Xue D,Yin H

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    journal_title:ACS chemical biology

    pub_type: 杂志文章


    authors: Xie P,Williams DS,Atilla-Gokcumen GE,Milk L,Xiao M,Smalley KS,Herlyn M,Meggers E,Marmorstein R

    更新日期:2008-05-16 00:00:00