The first two cell-fate decisions of preimplantation mouse embryo development are not functionally independent.

abstract：:Alveolar β2-receptor blockade worsens lung diffusion in heart failure (HF). This effect could be mitigated by stimulating alveolar β2-receptors. We investigated the safety and the effects of indacaterol on lung diffusion, lung mechanics, sleep respiratory behavior, cardiac rhythm, welfare, and exercise performance in ...

journal_title：Scientific reports

authors： Contini M,Spadafora E,Barbieri S,Gugliandolo P,Salvioni E,Magini A,Apostolo A,Palermo P,Alimento M,Agostoni P

更新日期：2020-04-28 00:00:00

abstract：:Wolfram syndrome (WS) is a recessive multisystem disorder defined by the association of diabetes mellitus and optic atrophy, reminiscent of mitochondrial diseases. The role played by mitochondria remains elusive, with contradictory results on the occurrence of mitochondrial dysfunction. We evaluated 13 recessive WS pa...

journal_title：Scientific reports

authors： La Morgia C,Maresca A,Amore G,Gramegna LL,Carbonelli M,Scimonelli E,Danese A,Patergnani S,Caporali L,Tagliavini F,Del Dotto V,Capristo M,Sadun F,Barboni P,Savini G,Evangelisti S,Bianchini C,Valentino ML,Liguori R,To

更新日期：2020-03-16 00:00:00

abstract：:We have analyzed the compositions of boron-carbon system, in which the [Formula: see text] compound is identified as structural stability at high pressure. The first-principles calculation is used to identify the phase diagram, electronic structure, and superconductivity of [Formula: see text]. Our results have demons...

journal_title：Scientific reports

authors： Tsuppayakorn-Aek P,Yang X,Pluengphon P,Luo W,Ahuja R,Bovornratanaraks T

更新日期：2020-10-22 00:00:00

abstract：:Herein, we demonstrate a simple yet novel luminescence assay for visual chiral discrimination of cysteine. Thioglycolic acid (TGA)-capped cadmium-telluride (CdTe) quantum dots (QDs) exposing green emission were directly synthesized in aqueous solution. The interaction between cysteine molecules and CdTe QDs induced th...

journal_title：Scientific reports

authors： Ghasemi F,Hormozi-Nezhad MR,Mahmoudi M

更新日期：2017-04-18 00:00:00

abstract：:Analysis of volatile organic compounds (VOCs) is a promising approach for non-invasive, fast and potentially inexpensive diagnostics. Here, we present a new methodology for profiling the body chemistry by using the volatile fraction of molecules in various body fluids. Using mass spectrometry and cross-reactive nanoma...

journal_title：Scientific reports

authors： Broza YY,Zuri L,Haick H

更新日期：2014-04-09 00:00:00

abstract：:Iron is an essential mineral required for most forms of life. However, very little is known in relation to the different forms of dietary iron on the development of NAFLD. The aims of this study were to investigate the effects of iron intake from different food types on risk of NAFLD and whether this effect may be mod...

journal_title：Scientific reports

authors： Peng XE,Xu SH,Liu W,Hu Z,Lin Z,Lin X

更新日期：2019-03-11 00:00:00

abstract：:We report command electro-optical switching on photolithographically-patterned graphene into a high-density electrode pattern for a high-transmission in-plane-switching (IPS) liquid crystal device. A highly-effective liquid crystal photoalignment method is used to maximize the field-driven optical contrast of a protot...

journal_title：Scientific reports

authors： Varanytsia A,Chien LC

更新日期：2017-09-18 00:00:00

abstract：:Relative gene expression analyses by RT-qPCR (reverse transcription-quantitative PCR) are highly dependent on the reference genes in normalizing the expression data of target genes. Therefore, inappropriate endogenous control genes will lead to inaccurate target gene expression profiles, and the selection and validati...

journal_title：Scientific reports

authors： Liang L,He Z,Yu H,Wang E,Zhang X,Zhang B,Zhang C,Liang Z

更新日期：2020-01-28 00:00:00

abstract：:The mammalian cochlea has historically resisted attempts at high-resolution, non-invasive imaging due to its small size, complex three-dimensional structure, and embedded location within the temporal bone. As a result, little is known about the relationship between an individual's cochlear pathology and hearing functi...

journal_title：Scientific reports

authors： Iyer JS,Batts SA,Chu KK,Sahin MI,Leung HM,Tearney GJ,Stankovic KM

更新日期：2016-09-16 00:00:00

abstract：:Traditionally, the practice of the tibial component placement in total knee arthroplasty has focused on achieving maximum coverage without malrotation. However, the concept of maximizing coverage has not been well defined or researched and yet biased results are often produced. This study aimed to evaluate the effect ...

journal_title：Scientific reports

authors： Shao L,Wu XD,Wang T,Liu XK,Xu W,Huang W,Zeng ZM

更新日期：2020-06-29 00:00:00

abstract：:At the regional scale, although environmental factors are known to shape the distributions of belowground communities in terrestrial ecosystems, these environmental factors account for relatively low percentages of the variation in belowground communities. More of this variation might be explained by considering ecosy...

journal_title：Scientific reports

authors： Wang B,Wu Y,Chen D

更新日期：2017-08-04 00:00:00

abstract：:Neural networks can efficiently encode the probability distribution of errors in an error correcting code. Moreover, these distributions can be conditioned on the syndromes of the corresponding errors. This paves a path forward for a decoder that employs a neural network to calculate the conditional distribution, then...

journal_title：Scientific reports

authors： Krastanov S,Jiang L

更新日期：2017-09-08 00:00:00

abstract：:The Serra Gaúcha region is the most important temperate fruit-producing area in southern Brazil. Despite mealybugs (Hemiptera: Pseudococcidae) infesting several host plants in the region, there is a lack of information about the composition of species damaging different crops. A survey of mealybug species associated w...

journal_title：Scientific reports

authors： Pacheco da Silva VC,Kaydan MB,Malausa T,Germain JF,Palero F,Botton M

更新日期：2017-11-16 00:00:00

abstract：:The impact of ctDNA changes after chemotherapy on the clinical outcomes of patients with metastatic colorectal cancer (mCRC) remains unclear. The present study evaluated the clinical implications of the early change in ctDNA levels as a predictor of objective response and clinical outcome in mCRC patients who received...

journal_title：Scientific reports

authors： Osumi H,Shinozaki E,Yamaguchi K,Zembutsu H

更新日期：2019-11-22 00:00:00

abstract：:Bacteria are able to de-epoxidize or epimerize deoxynivalenol (DON), a mycotoxin, to deepoxy-deoxynivalenol (deepoxy-DON or DOM-1) or 3-epi-deoxynivalenol (3-epi-DON), respectively. Using different approaches, the intestinal toxicity of 3 molecules was compared and the molecular basis for the reduced toxicity investig...

journal_title：Scientific reports

authors： Pierron A,Mimoun S,Murate LS,Loiseau N,Lippi Y,Bracarense AP,Schatzmayr G,He JW,Zhou T,Moll WD,Oswald IP

更新日期：2016-07-06 00:00:00

abstract：:The interpenetrating morphology formed by the electron donor and acceptor materials is critical for the performance of polymer:fullerene bulk heterojunction (BHJ) photovoltaic (PV) cells. In this work we carried out a systematic investigation on a high PV efficiency (>6%) BHJ system consisting of a newly developed 5,6...

journal_title：Scientific reports

authors： Xiao T,Xu H,Grancini G,Mai J,Petrozza A,Jeng US,Wang Y,Xin X,Lu Y,Choon NS,Xiao H,Ong BS,Lu X,Zhao N

更新日期：2014-06-09 00:00:00

abstract：:To date, there is only scarce evidence for a considerable association of subjective and objective stress measures, which might be attributable to method bias (e.g., confounding) and/or asynchrony of their temporal changes. To validate different subjective stress measures by a physiological measure of long-term stress ...

journal_title：Scientific reports

authors： Weckesser LJ,Dietz F,Schmidt K,Grass J,Kirschbaum C,Miller R

更新日期：2019-01-31 00:00:00

abstract：:Chemotaxonomy and the comparative analysis of metabolic features of fungi have the potential to provide valuable information relating to ecology and evolution, but have not been fully explored in fungal biology. Here, we investigated the chemical diversity of legume-associated Ascochyta and Phoma species and the possi...

journal_title：Scientific reports

authors： Kim W,Peever TL,Park JJ,Park CM,Gang DR,Xian M,Davidson JA,Infantino A,Kaiser WJ,Chen W

更新日期：2016-02-05 00:00:00

abstract：:Alternative splicing contributes to phenotypic diversity at multiple biological scales, and its dysregulation is implicated in both ageing and age-associated diseases in human. Cross-tissue variability in splicing further complicates its links to age-associated phenotypes and elucidating these links requires a compreh...

journal_title：Scientific reports

authors： Wang K,Wu D,Zhang H,Das A,Basu M,Malin J,Cao K,Hannenhalli S

更新日期：2018-07-19 00:00:00

abstract：:Inhibition of programmed death 1 (PD-1), expressed on activated T cells, can break through immune resistance and elicit durable responses in human melanoma as well as other types of cancers. Canine oral malignant melanoma is one of the most aggressive tumors bearing poor prognosis due to its high metastatic potency. H...

journal_title：Scientific reports

authors： Igase M,Nemoto Y,Itamoto K,Tani K,Nakaichi M,Sakurai M,Sakai Y,Noguchi S,Kato M,Tsukui T,Mizuno T

更新日期：2020-10-27 00:00:00

abstract：:Keratin 15 (K15), a type I keratin, which pairs with K5 in epidermis, has been used extensively as a biomarker for stem cells. Two commercial antibodies, LHK15, a mouse monoclonal and EPR1614Y, a rabbit monoclonal, have been widely employed to study K15 expression. Here we report differential reactivity of these antib...

journal_title：Scientific reports

authors： Aldehlawi H,Niemiec KA,Avisetti DR,Lalli A,Teh MT,Waseem A

更新日期：2019-02-13 00:00:00

abstract：:Nanostructure based color filtering has been considered an attractive replacement for current colorant pigmentation in the display technologies, in view of its increased efficiencies, ease of fabrication and eco-friendliness. For such structural filtering, iridescence relevant to its angular dependency, which poses a ...

journal_title：Scientific reports

authors： Shrestha VR,Lee SS,Kim ES,Choi DY

更新日期：2014-05-12 00:00:00

abstract：:Laser-driven ion acceleration is often analyzed assuming that ionization reaches a steady state early in the interaction of the laser pulse with the target. This assumption breaks down for materials of high atomic number for which the ionization occurs concurrently with the acceleration process. Using particle-in-cell...

journal_title：Scientific reports

authors： Li J,Arefiev AV,Bulanov SS,Kawahito D,Bailly-Grandvaux M,Petrov GM,McGuffey C,Beg FN

更新日期：2019-01-24 00:00:00

abstract：:SIRT1, the NAD+-dependent protein deacetylase, controls cell-cycle progression and apoptosis by suppressing p53 tumour suppressor. Although SIRT1 is known to be phosphorylated by JNK1 upon oxidative stress and subsequently down-regulated, it still remains elusive how SIRT1 stability and activity are controlled. Here, ...

journal_title：Scientific reports

authors： Kim M,Kwon YE,Song JO,Bae SJ,Seol JH

更新日期：2016-11-24 00:00:00

abstract：:Ursolic acid (UA) has proved to have broad-spectrum anti-tumor effects, but its poor water solubility and incompetent targeting property largely limit its clinical application and efficiency. Here, we synthesized a nanoparticle-based drug carrier composed of chitosan, UA and folate (FA-CS-UA-NPs) and demonstrated that...

journal_title：Scientific reports

authors： Jin H,Pi J,Yang F,Jiang J,Wang X,Bai H,Shao M,Huang L,Zhu H,Yang P,Li L,Li T,Cai J,Chen ZW

更新日期：2016-07-29 00:00:00

abstract：:Exposure to stress during early life affects subsequent behaviors and increases the vulnerability to adult pathologies, a phenomenon that has been well documented in humans and rodents. In this study, we introduce a chronic unpredictable stress protocol adapted to young zebrafish, which is an increasingly popular vert...

journal_title：Scientific reports

authors： Golla A,Østby H,Kermen F

更新日期：2020-06-25 00:00:00

abstract：:SERS spectra excited at 785 nm of the bacteria Chlamydia trahomatis (elementary bodies, EB) and Neisseria gonorrheoae, the causative pathogens for the two most common sexually transmitted diseases (STD), chlamydia and gonorrhea, respectively, are reported. Although both are Gram-negative bacteria, the SERS signatures ...

journal_title：Scientific reports

authors： Chen Y,Premasiri WR,Ziegler LD

更新日期：2018-03-26 00:00:00

abstract：:Meteorite impacts have caused catastrophic perturbations to the global environment and mass extinctions throughout the Earth's history. Here, we present petrographic and geochemical evidence of a possible impact ejecta layer, dating from about 11 Ma, in deep-sea clayey sediment in the Northwest Pacific. This clay laye...

journal_title：Scientific reports

authors： Nozaki T,Ohta J,Noguchi T,Sato H,Ishikawa A,Takaya Y,Kimura JI,Chang Q,Shimada K,Ishibashi JI,Yasukawa K,Kimoto K,Iijima K,Kato Y

更新日期：2019-11-20 00:00:00

abstract：:The global loss of biodiversity can be attributed to numerous threats. While pioneer studies have investigated their relative importance, the majority of those studies are restricted to specific geographic regions and/or taxonomic groups and only consider a small subset of threats, generally in isolation despite their...

journal_title：Scientific reports

authors： Leclerc C,Courchamp F,Bellard C

更新日期：2018-04-23 00:00:00

abstract：:Previously, Aznar et al., showed that Daple/CCDC88C enables Wnt receptors to transactivate trimeric G-proteins during non-canonical Wnt signaling via a novel G-protein binding and activating (GBA) motif. By doing so, Daple serves two opposing roles; earlier during oncogenesis it suppresses neoplastic transformation an...

journal_title：Scientific reports

authors： Ear J,Dunkel Y,Mittal Y,Lim BBC,Liu L,Holda MK,Nitsche U,Barbazán J,Goel A,Janssen KP,Aznar N,Ghosh P

更新日期：2019-08-20 00:00:00