Experimental evidence for the therapeutic potential of tempol in the treatment of acute liver injury.

abstract：:This study investigated the anticancer effects of embelin in human gastric cancer cells and the underlying molecular mechanisms. Gastric cancer cells were treated with embelin and 5-FU for methyl-thiazolyl-tetrazolium bromide cell viability assay and flow cytometric detection of cell viability and apoptosis. Protein p...

journal_title：Molecular and cellular biochemistry

authors： Wang DG,Sun YB,Ye F,Li W,Kharbuja P,Gao L,Zhang DY,Suo J

更新日期：2014-01-01 00:00:00

abstract：:This study has examined whether elevated glucose can induce lipid peroxidation and contribute to the inhibition of cell growth in human kidney proximal tubule(HPT) cells. HPT cells were cultured in media containing glucose concentrations of 8 mM (control), 25 mM, and 50 mM. Lipid peroxidation was assessed by the thiob...

journal_title：Molecular and cellular biochemistry

authors： Jain SK,Morshed KM,Kannan K,McMartin KE,Bocchini JA Jr

更新日期：1996-09-06 00:00:00

abstract：:Transport characteristics of essential trace elements as zinc, copper, selenium and iron have been studied in maternal-fetal direction in normal pregnancies, using in vitro perfusion of human placental lobules. Solutions of trace elements corresponding to twice the physiological concentrations were injected (100 micro...

journal_title：Molecular and cellular biochemistry

authors： Nandakumaran M,Dashti HM,Al-Saleh E,Al-Zaid NS

更新日期：2003-10-01 00:00:00

abstract：:Membranous guanylate cyclase in retinal photoreceptor outer segments (ROS-GC), a key enzyme for the recovery of photoreceptors to the dark state, has a topology identical to and cytoplasmic domains homologous to those of peptide-regulated GCs. However, under the prevailing concept, its activation mechanism is signific...

journal_title：Molecular and cellular biochemistry

authors： Bondarenko VA,Hayashi F,Usukura J,Yamazaki A

更新日期：2010-01-01 00:00:00

abstract：:TGR(mREN2)27 is a transgenic rat harboring the murine Ren-2 gene and exhibit fulminant hypertension and marked heart hypertrophy. In order to study the role of angiotensin II in the increase of cardiac mass, these animals were treated with antihypertensive and non-antihypertensive doses of the angiotensin II receptor ...

journal_title：Molecular and cellular biochemistry

authors： Böhm M,Lippoldt A,Wienen W,Ganten D,Bader M

更新日期：1996-10-01 00:00:00

abstract：:Bipolar disorder (BD) is a psychiatric disorder characterized by alternating episodes of mania and depression. The intracerebroventricular (i.c.v) administration of ouabain (a Na(+)/K(+)-ATPase inhibitor) in rats has been used as an animal model of mania, because present face, construct and predictive validities. Seve...

journal_title：Molecular and cellular biochemistry

authors： Freitas TP,Rezin GT,Gonçalves CL,Jeremias GC,Gomes LM,Scaini G,Teodorak BP,Valvassori SS,Quevedo J,Streck EL

更新日期：2010-08-01 00:00:00

abstract：:Acrolein is a highly reactive alpha, beta-unsaturated aldehyde, and a product of lipid peroxidation reactions. Acrolein is also an environmental pollutant and a key component of cigarette smoke, and has been implicated in multiple respiratory diseases. Lung tissue is a primary target for acrolein toxicity in smokers a...

journal_title：Molecular and cellular biochemistry

authors： Sarkar P,Hayes BE

更新日期：2007-07-01 00:00:00

abstract：:The RNase hydrolysis of random-coil (alkaline form) poly A follows biphasic kinetics at low salt concentrations. However, its resistance to RNase increases with the ionic strength. Helical (acidic form) poly A is alos susceptible to RNase but its hydrolysis follows first-order kinetics, and its resistance increases as...

journal_title：Molecular and cellular biochemistry

authors： Iqbal ZM

更新日期：1975-10-31 00:00:00

abstract：:Interleukin-1beta (IL-1) is a potent inducer of prostaglandin E2 (PGE2) synthesis. We previously showed that ceramide accumulates in fibroblasts treated with IL-1 and that it enhances IL-1-induced PGE2 production. The present study was undertaken to determine the mechanism(s) by which ceramide and IL-1 interact to enh...

journal_title：Molecular and cellular biochemistry

authors： Kirtikara K,Laulederkind SJ,Raghow R,Kanekura T,Ballou LR

更新日期：1998-04-01 00:00:00

abstract：:The deiodinases regulate the activation and inactivation of Thyroid hormones (TH), in both physiological and pathological conditions. The three deiodinases, DIO1, DIO2 and DIO3, have different catalytic role and cellular and tissue distribution. Aim of this study is to evaluate a rat model of regional ischemia/reperfu...

journal_title：Molecular and cellular biochemistry

authors： Sabatino L,Kusmic C,Iervasi G

更新日期：2020-12-01 00:00:00

abstract：:A liver cytochrome P-450 isozyme has been purified to homogeneity from protein-energy malnourished rats induced with beta-naphthoflavone (beta-NF). The purification steps included chromatography on DEAE-Sephadex-A-25, DEAE-cellulose (DE-53), hydroxylapatite (HA) and carboxymethyl-sephadex (CM) columns. The reduced car...

journal_title：Molecular and cellular biochemistry

authors： Gil L,Vasquez H,Orellana M,Selkirk J,Wold F,Strobel H

更新日期：1988-01-01 00:00:00

abstract：:The antioxidant activity of anthocyanins has been well characterized in vitro; many cases has been postulated to provide an important exogenous mediator of oxidative stress in the gastrointestinal tract. The objective of this study was to evaluate the efficacy of anthocyanin protection against peroxyl radical (AAPH)-i...

journal_title：Molecular and cellular biochemistry

authors： Elisia I,Kitts DD

更新日期：2008-05-01 00:00:00

abstract：:Inadequate migration and invasion of the trophoblast cells during embryo implantation is one of the reasons for pregnancy-related complications such as intrauterine growth restriction and preeclampsia. In the present study, relevance of WNT ligands and integrins associated with hepatocyte growth factor (HGF)-mediated ...

journal_title：Molecular and cellular biochemistry

authors： Chaudhary P,Malhotra SS,Babu GS,Sobti RC,Gupta SK

更新日期：2019-03-01 00:00:00

abstract：:Immunoassays such as rocket immunoelectrophoresis, western dot blot hybridization, and competitive ELISA analysis were used to estimate and compare homology among fishes (several species), crab, toad, chicken and rodent metallothioneins. The relative abundance of tissue-specific metallothionein in catfish was highest ...

journal_title：Molecular and cellular biochemistry

authors： Chatterjee A,Maiti IB

更新日期：1990-05-10 00:00:00

abstract：:This study examined the role of the protein kinase C (PKC) signalling pathway in the regulation of expression of human complement factor I (CFI) gene. The production of CFI by Hep G2 cells was enhanced in a dose- and time-dependent fashion by 12-O-tetradecanoyl-1,2-phorbol 13-acetate (TPA), a potent PKC activator. 4Al...

journal_title：Molecular and cellular biochemistry

authors： Minta J,Fung M

更新日期：1999-11-01 00:00:00

abstract：:A multi-component solution, containing α-ketoglutaric acid (α-KG), 5-hydroxymethylfurfural (5-HMF), N-acetyl-seleno-L-methionine (NASeLM), and N-acetyl-L-methionine (NALM) as active ingredients, has been tested considering its supposed antioxidative effect with respect to heart transplantations. Oxidative stress was i...

journal_title：Molecular and cellular biochemistry

authors： Russ M,Jauk S,Wintersteiger R,Andrä M,Brcic I,Ortner A

更新日期：2019-11-01 00:00:00

abstract：:Chemotherapy remains the core of anticancer treatment. However, despite the tremendous strides made in the development of targeted anticancer therapies, emergence of resistance to chemotherapeutic drugs is still a major obstacle in the successful management of resistant tumors. Therefore, profound investigation into t...

journal_title：Molecular and cellular biochemistry

authors： Peng L,Zhu H,Wang J,Sui H,Zhang H,Jin C,Li L,Xu T,Miao R

更新日期：2015-07-01 00:00:00

abstract：:Sensitive to Apoptosis Gene (SAG), a RING component of SCF E3 ubiquitin ligase, was shown to be phosphorylated by protein kinase CK2 at the Thr10 residue. It is, however, unknown whether this phosphorylation is stress-responsive or whether the phosphorylation changes its E3 ubiquitin ligase activity. To address these,...

journal_title：Molecular and cellular biochemistry

authors： He H,Tan M,Pamarthy D,Wang G,Ahmed K,Sun Y

更新日期：2007-01-01 00:00:00

abstract：:Ran-binding protein in microtubule-organizing center (RanBPM) has been reported to interact with the neurotrophin receptors p75NTR and TrkA, meanwhile p75NTR and TrkA can also interact with TRAF6. Whether RanBPM interacts directly with TRAF6 has not yet been established. In this study, using a yeast two-hybrid system ...

journal_title：Molecular and cellular biochemistry

authors： Wang L,Fu C,Cui Y,Xie Y,Yuan Y,Wang X,Chen H,Huang BR

更新日期：2012-01-01 00:00:00

abstract：:Since the glucose-lowering effects of vanadium could be related to increased muscle glycogen synthesis, we examined the in vivo effects of vanadium and insulin treatment on glycogen synthase (GS) activation in Zucker fatty rats. The GS fractional activity (GSFA), protein phosphatase-1 (PP1), and glycogen synthase kina...

journal_title：Molecular and cellular biochemistry

authors： Semiz S,McNeill JH

更新日期：2002-07-01 00:00:00

abstract：:Hypertriglyceridemia is a common complex metabolic trait that is associated with increased atherosclerosis risk, presence of the metabolic syndrome and, with extreme elevation, increased risk of pancreatitis. Hierarchical cluster analysis using clinical and biochemical features of the Frederickson hyperlipoproteinemia...

journal_title：Molecular and cellular biochemistry

authors： Hegele RA,Pollex RL

更新日期：2009-06-01 00:00:00

abstract：:Antecedent studies have suggested that lipid composition and fluidity of cellular membranes of various organs are altered in response to thyroid hormone status. To date, the effects of thyroid hormone status on these parameters have not been examined in rat renal apical membrane in regard to sodium-dependent phosphate...

journal_title：Molecular and cellular biochemistry

authors： Prasad R,Kumar V

更新日期：2005-01-01 00:00:00

abstract：:Previous studies reported that estrogen receptor β (ERβ) is localized to mitochondria, whereas little is known about the physiological functions of mitochondrial ERβ. In the present study, we explored the role of mitochondrial ERβ in regulating apoptosis using stable ERβ-expressing and ERβ knockdown cells lines. We fo...

journal_title：Molecular and cellular biochemistry

authors： Liang J,Xie Q,Li P,Zhong X,Chen Y

更新日期：2015-03-01 00:00:00

abstract：:In this study, we aimed to study the role of miRNAs in intrauterine adhesion (IUA) disease. An IUA cell model was constructed by TGF-β1. Smad3 inhibitor (SIS3) can inhibit the Smad3 signaling pathway and affect the role of TGF-β1; thus, it was used to identify the role of Smad3 and related miRNAs in IUA. Cell number s...

journal_title：Molecular and cellular biochemistry

authors： Liu S,Huang X,Liu Y,Song D,Xiao Y

更新日期：2020-07-01 00:00:00

abstract：:This paper reviews characteristics of microsomal membrane structure; long chain fatty acids, acyl CoA derivatives, retinoids and the microsomal formation of acyl CoA derivatives and retinyl esters. It is analyzed how the movement of these molecules at the intracellular level is affected by their respective binding pro...

journal_title：Molecular and cellular biochemistry

authors： Catalá A

更新日期：1993-03-24 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is one of the rare cancers in western countries but predominant in Southeast Asian countries including Thailand. One major cause for failure of NPC chemotherapeutic treatments is reportedly correlated with the elevation of cancer stem cell (CSC) fractions. Thus, this present study aims t...

journal_title：Molecular and cellular biochemistry

authors： Sinnung S,Janvilisri T,Kiatwuthinon P

更新日期：2021-01-09 00:00:00

abstract：:It has been reported that mitochondria-independent or mitochondria-dependent (type I/II) Fas signaling pathways in leukemia cells depend on the amount of active caspase-8. However, Bid molecules, which could not be cleaved in type I cells, could be effectively cleaved by recombinant active caspase-8 in vitro. The clea...

journal_title：Molecular and cellular biochemistry

authors： Li Y,Qi L,Iwao A,Kihira K,Dida F,Song Z,Azuma E,Komada Y

更新日期：2009-11-01 00:00:00

abstract：:Y-box binding protein-1 (YB-1), a member of Y-box protein family binding DNA and RNA, has been proposed as a novel marker in multiple malignant tumors and found to be associated with tumor malignancy. Neuroblastoma is an embryonal tumor arising from neuroblast cells of the autonomic nervous system, which is the most c...

journal_title：Molecular and cellular biochemistry

authors： Wang H,Sun R,Chi Z,Li S,Hao L

更新日期：2017-09-01 00:00:00

abstract：:The mainstream explanation of enzyme catalysis relies on the assumption that enzymes can utilize the binding energy. The author suggest that (i) an enzyme with excess free energy first gives a group from its active site into the final place of the bound reactant (substrate) in order to break the first initial chemical...

journal_title：Molecular and cellular biochemistry

authors： Foigel AG

更新日期：2011-06-01 00:00:00

abstract：:Velocardiofacial syndrome (VCFS) is a relatively common developmental disorder characterized by craniofacial anomalies and conotruncal heart defects. Many VCFS patients present hemizygous deletions on part of chromosome 22q11.2; suggestive that haploinsufficiency in this region is responsible for this etiology. Most 2...

journal_title：Molecular and cellular biochemistry

authors： Sandrin-Garcia P,Abramides DV,Martelli LR,Ramos ES,Richieri-Costa A,Passos GA

更新日期：2007-09-01 00:00:00