Abstract:
:The mainstream explanation of enzyme catalysis relies on the assumption that enzymes can utilize the binding energy. The author suggest that (i) an enzyme with excess free energy first gives a group from its active site into the final place of the bound reactant (substrate) in order to break the first initial chemical bond; (ii) this enzyme accepts a similar group from the second bound reactant (or second group in the case of the single-substrate) into active site and finish the substrate conversion and enzyme regeneration. The detailed mechanisms of the well-studied reactions of peptide bond hydrolysis catalyzed by α-chymotrypsin and the glyceraldehyde-3-phosphate interconversion steps in glycolysis are in accordance with the proposed theoretical conclusions.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Foigel AGdoi
10.1007/s11010-011-0742-4subject
Has Abstractpub_date
2011-06-01 00:00:00pages
87-9issue
1-2eissn
0300-8177issn
1573-4919journal_volume
352pub_type
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