Asthma treatments: new and emerging therapies.

abstract：BACKGROUND:Frontal sinus cerebrospinal fluid (CSF) leaks have traditionally been repaired via open procedures (eg, osteoplastic flap or cranialization). Advancements in instrumentation, technique, and experience have improved the feasibility of repairing frontal sinus skull-base defects using an endoscopic approach. Th...

journal_title：International forum of allergy & rhinology

authors： Jones V,Virgin F,Riley K,Woodworth BA

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Poor sleep quality is common in chronic rhinosinusitis (CRS). Prior studies have demonstrated improvements in patient-reported measures of sleep quality following endoscopic sinus surgery (ESS). The purpose of this study was to evaluate the effect of ESS on objective sleep parameters and identify any associa...

journal_title：International forum of allergy & rhinology

authors： Little RE,Alt JA,Ramakrishnan VR,Platt MP,Schlosser RJ,Storck KA,Soler ZM

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:The etiology of the intense inflammatory response showed by patients with allergic fungal rhinosinusitis (AFRS) remains a mystery. Potential sources of this inflammation may include fungal proteases. Protease-activated receptors (PARs) are components of the innate immune response that are modulated by proteo...

journal_title：International forum of allergy & rhinology

authors： Ebert CS Jr,McKinney KA,Urrutia G,Wu M,Rose AS,Fleischman GM,Thorp B,Senior BA,Zanation AM

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The role of bacteria in the pathogenesis of chronic rhinosinusitis (CRS) remains uncertain. Recent evidence suggests that bacteria are able to establish microcolonies within the underlying mucosa. However, to date there has been no systematic comparison of bacterial community composition and diversity in the...

journal_title：International forum of allergy & rhinology

authors： Kim RJ,Biswas K,Hoggard M,Taylor MW,Douglas RG

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:The correct use of inhalation devices is essential for successful therapy. We aimed to evaluate the skills in the use of a spacer device with an metered-dose inhaler (MDI) and factors that influence this skill in asthmatic preschool children's caregivers. METHODS:The caregivers of 12-month-old to 72-month-o...

journal_title：International forum of allergy & rhinology

authors： Topal E,Celiksoy MH,Catal F,Sinanoglu MS,Karakoc HT,Sancak R,Ozturk F

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Many asthmatic patients have coexisting allergic rhinitis (AR). This study aims to investigate the compliance of physicians with respiratory medicine specialty (PRMs) to Global Initiative for Asthma (GINA) and Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines during the management of their asthma-...

journal_title：International forum of allergy & rhinology

authors： Su N,Lin J,Liu G,Yin K,Zhou X,Shen H,Chen P,Chen R,Liu C,Wu C,Zhao J,Lin Y

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Allergy-related illness impacts millions of individuals worldwide. Our objectives were to characterize current trends of clinical trials research relating to allergen immunotherapy and to describe the landscape of allergen immunotherapy in National Institutes of Health (NIH)-supported research inquiry. METH...

journal_title：International forum of allergy & rhinology

authors： Ramsey T,Lai W,Svider PF,Hojjat H,Eloy JA,Folbe AJ

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The influence of the microbial community on inflammatory subtype in chronic rhinosinusitis (CRS) has been proposed. Superantigen mechanisms potentially create a T helper 2 (Th-2)/eosinophilic dominated inflammation as a product of local flora rather than an intrinsic mucosal process. The associations between...

journal_title：International forum of allergy & rhinology

authors： Rom D,Snidvongs K,Sacks PL,Dalgorf D,Pratt E,Earls P,Sacks R,Harvey RJ

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:This analysis explores the increasing heterogeneity of trends in allergy management under the premise that the practice of allergy has undergone significant changes in national economics, healthcare delivery, and treatment options from 2007 to 2016. METHODS:Centers for Medicare and Medicaid Services (CMS) d...

journal_title：International forum of allergy & rhinology

authors： Arianpour K,Svider PF,Yuhan B,Hooda Z,Eloy JA,Folbe AJ

更新日期：2018-05-21 00:00:00

abstract：BACKGROUND:The management of chronic rhinosinusitis with nasal polyposis (CRSwNP) becomes unclear when patients require multiple courses of corticosteroids to maintain quality of life. Repeated courses of corticosteroids carry increased risks to patients. Although endoscopic sinus surgery (ESS) is an effective therapeu...

journal_title：International forum of allergy & rhinology

authors： Leung RM,Dinnie K,Smith TL

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis (CRS) is a common condition encountered in primary care medicine and is estimated to affect 12.5% of the United States population. This study aims to compare methods of assessing health utility in CRS. METHODS:A cross-sectional sample of CRS patients (n = 137) were interviewed using d...

journal_title：International forum of allergy & rhinology

authors： Ference EH,Stubbs V,Lidder AK,Chandra RK,Conley D,Avila PC,Hirsch AG,Min JY,Smith SS,Kern RC,Tan BK

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Nonallergic rhinitis (NAR) is currently a diagnosis of exclusion with an unclear pathophysiologic mechanism and limited treatment options. In patients diagnosed with NAR based on symptoms, negative skin testing and positive optical rhinometry (ORM), the study's objective was to evaluate the therapeutic actio...

journal_title：International forum of allergy & rhinology

authors： Zebda D,Jiang ZY,Gibson MM,Pham C,Ahmadi S,Floren S,Yao WC,Citardi MJ,Luong AU

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Allergic rhinitis (AR) is a chronic systemic allergic disease with an association reported between allergy and anxiety. The objective of the current study was therefore to investigate and retrospectively evaluate the factors that may possibly induce state and trait anxiety among patients with AR and vasomoto...

journal_title：International forum of allergy & rhinology

authors： Xi L,Cao F,Zhang Y,Zhang L

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:The relationship between olfactory function, rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin' Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical ...

journal_title：International forum of allergy & rhinology

authors： Ottaviano G,Cantone E,D'Errico A,Salvalaggio A,Citton V,Scarpa B,Favaro A,Sinisi AA,Liuzzi R,Bonanni G,Di Salle F,Elefante A,Manara R,Staffieri A,Martini A,Brunetti A

更新日期：2015-09-01 00:00:00

abstract：:Recent evidence has demonstrated an expanding role of respiratory epithelial cells in immune surveillance and modulation. Studies have been focusing on the earliest events that link epithelial injury to downstream inflammatory responses. Cytokines produced by and released from respiratory epithelial cells are among th...

journal_title：International forum of allergy & rhinology

authors： Patel NN,Kohanski MA,Maina IW,Workman AD,Herbert DR,Cohen NA

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Olfactory-specific quality of life (QOL) can be measured using the Questionnaire of Olfactory Disorders-Negative Statements (QOD-NS), which examines various aspects of olfactory dysfunction. It is unknown if certain factors of the QOD-NS differentially impact QOL. METHODS:Patients with chronic rhinosinusiti...

journal_title：International forum of allergy & rhinology

authors： Mattos JL,Schlosser RJ,DeConde AS,Hyer M,Mace JC,Smith TL,Soler ZM

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine whether anterior rhinoscopy (AR), nasal endoscopy (NE) and paranasal sinus computed tomography (PNS CT) can predict other sinonasal obstructive pathologies in the setting of nasal septal deviation (NSD), and to evaluate the impact of preoperative PNS CT on the decision ...

journal_title：International forum of allergy & rhinology

authors： Günbey E,Günbey HP,Uygun S,Karabulut H,Cingi C

更新日期：2015-09-01 00:00:00

abstract：:Early reports have suggested that smell loss may be an early symptom associated with the pandemic known as coronavirus disease 2019 (COVID-19). The possibility that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might cause olfactory dysfunction is certainly plausible. Patients presenting to specialized ...

journal_title：International forum of allergy & rhinology

authors： Soler ZM,Patel ZM,Turner JH,Holbrook EH

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Olfactory inflammation in chronic rhinosinusitis (CRS) is associated with cytokines that may result in the death of olfactory sensory neurons. The principal signaling molecules involved in the apoptotic pathway are c-Jun N-terminal kinases (JNK). Although the JNK pathway has emerged as a key player in progra...

journal_title：International forum of allergy & rhinology

authors： Victores AJ,Chen M,Smith A,Lane AP

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:The purpose of this work was to describe a clinical and radiographic pattern of findings that helps localize the site of spontaneous cerebrospinal fluid (CSF) leaks. METHODS:This study was a retrospective review of CSF leaks treated at the University of Texas Southwestern Medical Center from 2000 to 2009. D...

journal_title：International forum of allergy & rhinology

authors： Manes RP,Ryan MW,Marple BF

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The mechanism of airway remodeling in chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unknown. We wished to determine whether profibrotic transforming growth factor beta 1 (TGF-β1) and activin A and their downstream signaling proteins are increased in CRSwNP and if they are regulated in epitheli...

journal_title：International forum of allergy & rhinology

authors： Yamin M,Holbrook EH,Gray ST,Busaba NY,Lovett B,Hamilos DL

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:The pathophysiologic mechanism of allergy is dependent on the action of many redox-sensitive proinflammatory mediators. However, even though redox disturbances are believed to be a hallmark of inflammation, little is known of the effect of redox imbalance to the pathophysiology of allergic rhinitis. We thus ...

journal_title：International forum of allergy & rhinology

authors： Guibas GV,Spandou E,Meditskou S,Vyzantiadis TA,Priftis KN,Anogianakis G

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Surgical management of the superior turbinate (ST) is required to access the sella in endoscopic endonasal transsphenoidal surgery (EETS) for pituitary adenoma. Two common ST management techniques include partial resection of the ST (PRST) and intentional lateralization of the ST (ILST). Given the concentrat...

journal_title：International forum of allergy & rhinology

authors： Li P,Luo K,Zhang Q,Wang Z

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Inverted papilloma is a benign sinonasal tumor that arises from a localized attachment site. These attachment sites, however, have not been fully characterized in the literature. The objective of this research was to determine the specific distribution of attachment sites in patients with sinonasal papilloma...

journal_title：International forum of allergy & rhinology

authors： Schneyer MS,Milam BM,Payne SC

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Most data on sinonasal mucosal melanoma come from small institutional studies, and therefore optimal treatment methods are not well understood. The purpose of this study was to analyze the association between treatment and survival in sinonasal mucosal melanoma. METHODS:Six hundred ninety-five patients diag...

journal_title：International forum of allergy & rhinology

authors： Konuthula N,Khan MN,Parasher A,Del Signore A,Genden EM,Govindaraj S,Iloreta AM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The objective of this work was to evaluate prevalence of eosinophilic esophagitis (EoE) in the United States, and analyze prevalence of atopic disease in patients with EoE. The study design was a retrospective administrative database analysis in U.S.-based outpatient settings. METHODS:A retrospective claims...

journal_title：International forum of allergy & rhinology

authors： Benninger MS,Strohl M,Holy CE,Hanick AL,Bryson PC

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The role that bacterial biofilms might play in recalcitrant forms of chronic rhinosinusitis (CRS) is increasingly being recognized. However, the detection of bacteria existing in this form, using standard culture, is limited by their unique metabolically inactive properties. All current biofilm diagnostic mo...

journal_title：International forum of allergy & rhinology

authors： Foreman A,Jervis-Bardy J,Boase SJ,Tan L,Wormald PJ

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:The extracellular matrix (ECM) is a potentially important component of mucosal immunity. ECM dysregulation in chronic rhinosinusitis (CRS) is suggested by genomewide association studies identifying ECM genes as top candidates. Further support is afforded by the demonstration of increased expression of perios...

journal_title：International forum of allergy & rhinology

authors： Zhang W,Hubin G,Endam LM,Al-Mot S,Filali-Mouhim A,Desrosiers M

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The Draf III procedure is an effective endoscopic approach to the treatment of frontal sinus disorders, but has a significant restenosis rate. The objective of the current study is to assess long-term success of the Draf III mucosal grafting technique. METHODS:Patients undergoing Draf III with mucosal graft...

journal_title：International forum of allergy & rhinology

authors： Illing EA,Cho do Y,Riley KO,Woodworth BA

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Staphylococcus aureus infection is known to play a role in recalcitrant chronic rhinosinusitis (CRS). However, it is unknown if recurrent S. aureus infections are caused by the same strain or are due to independent acquisitions of different strains. METHODS:Samples were collected from patients with CRS from...

journal_title：International forum of allergy & rhinology

authors： Drilling A,Coombs GW,Tan HL,Pearson JC,Boase S,Psaltis A,Speck P,Vreugde S,Wormald PJ

更新日期：2014-12-01 00:00:00