Abstract:
:In eukaryotes, cytosolic monothiol glutaredoxins are proteins implicated in intracellular iron trafficking and sensing via their bound [2Fe-2S] clusters. We define a new role of human cytosolic monothiol glutaredoxin-3 (GRX3) in transferring its [2Fe-2S] clusters to human anamorsin, a physical and functional protein partner of GRX3 in the cytosol, whose [2Fe-2S] cluster-bound form is involved in the biogenesis of cytosolic and nuclear Fe-S proteins. Specific protein recognition between the N-terminal domains of the two proteins is the mandatory requisite to promote the [2Fe-2S] cluster transfer from GRX3 to anamorsin.
journal_name
Nat Chem Bioljournal_title
Nature chemical biologyauthors
Banci L,Ciofi-Baffoni S,Gajda K,Muzzioli R,Peruzzini R,Winkelmann Jdoi
10.1038/nchembio.1892subject
Has Abstractpub_date
2015-10-01 00:00:00pages
772-8issue
10eissn
1552-4450issn
1552-4469pii
nchembio.1892journal_volume
11pub_type
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