Abstract:
:Helical membrane proteins are typically assumed to attain stable transmembrane topologies immediately upon co-translational membrane insertion. Here we show that unassembled monomers of the small multidrug resistance (SMR) family exist in a dynamic equilibrium where the N-terminal transmembrane helix flips in and out of the membrane, with rates that depend on dimerization and the polypeptide sequence. Thus, membrane topology can display rapid dynamics in vivo and can be regulated by post-translational assembly.
journal_name
Nat Chem Bioljournal_title
Nature chemical biologyauthors
Seurig M,Ek M,von Heijne G,Fluman Ndoi
10.1038/s41589-019-0356-9subject
Has Abstractpub_date
2019-10-01 00:00:00pages
945-948issue
10eissn
1552-4450issn
1552-4469pii
10.1038/s41589-019-0356-9journal_volume
15pub_type
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