Abstract：
:We estimated the dynamic cell metabolic activity and the distribution of the pH value and oxygen concentration in tissue samples cultured in vitro by using real-time sensor records and a numerical simulation of the underlying reaction-diffusion processes. As an experimental tissue model, we used chicken spleen slices. A finite element method model representing the biochemical processes and including the relevant sensor data was set up. By fitting the calculated results to the measured data, we derived the spatiotemporal values of the pH value, the oxygen concentration and the absolute metabolic activity (extracellular acidification and oxygen uptake rate) of the samples. Notably, the location of the samples in relation to the sensors has a great influence on the detectable metabolic rates. The long-term vitality of the tissue samples strongly depends on their size. We further discuss the benefits and limitations of the model.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Pfister C,Forstmeier C,Biedermann J,Schermuly J,Demmel F,Wolf P,Kaspers B,Brischwein Mdoi
10.1007/s11517-015-1367-7subject
Has Abstractpub_date
2016-05-01 00:00:00pages
763-72issue
5eissn
0140-0118issn
1741-0444pii
10.1007/s11517-015-1367-7journal_volume
54pub_type
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