Abstract:
:Alzheimer's disease is a neurodegenerative disease associated with progressive memory and cognitive decline. Previous studies have identified the benefits of cognitive enrichment on reducing disease pathology. Additionally, epidemiological and clinical data suggest that repeated exercise, and cognitive and social enrichment, can improve and/or delay the cognitive deficiencies associated with aging and neurodegenerative diseases. In the present study, 3xTg-AD mice were exposed to a rigorous training routine beginning at 3 months of age, which consisted of repeated training in the Morris water maze spatial recognition task every 3 months, ending at 18 months of age. At the conclusion of the final Morris water maze training session, animals subsequently underwent testing in another hippocampus-dependent spatial task, the Barnes maze task, and on the more cortical-dependent novel object recognition memory task. Our data show that periodic cognitive enrichment throughout aging, via multiple learning episodes in the Morris water maze task, can improve the memory performance of aged 3xTg-AD mice in a separate spatial recognition task, and in a preference memory task, when compared to naïve aged matched 3xTg-AD mice. Furthermore, we observed that the cognitive enrichment properties of Morris water maze exposer, was detectable in repeatedly trained animals as early as 6 months of age. These findings suggest early repeated cognitive enrichment can mitigate the diverse cognitive deficits observed in Alzheimer's disease.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Martinez-Coria H,Yeung ST,Ager RR,Rodriguez-Ortiz CJ,Baglietto-Vargas D,LaFerla FMdoi
10.1016/j.brainresbull.2015.07.001subject
Has Abstractpub_date
2015-08-01 00:00:00pages
10-5eissn
0361-9230issn
1873-2747pii
S0361-9230(15)30011-3journal_volume
117pub_type
杂志文章abstract::Serotonergic modulation of acetylcholine (ACh) release after neuron-specific increase of the expression of 5-HT(1B) receptors by gene transfer was studied in vitro and in vivo. The increased expression of the 5-HT(1B) receptor in vitro was induced by treating rat primary fetal septal cell cultures for 3 days with a vi...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2008.01.015
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(85)90008-5
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journal_title:Brain research bulletin
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2016.04.003
更新日期:2016-06-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2016.06.016
更新日期:2016-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(90)90117-i
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2011.03.001
更新日期:2011-05-30 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90071-5
更新日期:1992-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(88)90047-0
更新日期:1988-11-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90036-j
更新日期:1991-11-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90020-x
更新日期:1992-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-11-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(01)00536-6
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(02)00827-4
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(88)90222-5
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pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
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pub_type: 杂志文章
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