Failure dynamics of the global risk network.

abstract：:PCR-mediated chromosome splitting (PCS) was developed in the yeast Saccharomyces cerevisiae. It is based on homologous recombination and enables division of a chromosome at any point to form two derived and functional chromosomes. However, because of low homologous recombination activity, PCS is limited to a single si...

journal_title：Scientific reports

authors： Sasano Y,Nagasawa K,Kaboli S,Sugiyama M,Harashima S

更新日期：2016-08-17 00:00:00

abstract：:Metasurfaces, owing to their attractive features, provide a wide range of potential applications. Electromagnetic absorbers based on metasurfaces have significantly improved responses compared to the earlier absorbers made from composite materials. Active metasurfaces, in contrast to the passive designs, can exhibit m...

journal_title：Scientific reports

authors： Ghosh S,Lim S

更新日期：2018-07-05 00:00:00

abstract：:Stimuli presented at short temporal delays before functional magnetic resonance imaging (fMRI) can have a robust impact on the organization of synchronous activity in resting state networks. This presents an opportunity to investigate how sensory, affective and cognitive stimuli alter functional connectivity in rodent...

journal_title：Scientific reports

authors： Pompilus M,Colon-Perez LM,Grudny MM,Febo M

更新日期：2020-11-16 00:00:00

abstract：:Peripheral nerve long gap defects are a clinical challenge in the regeneration field. Despite the wide variety of surgical techniques and therapies, autografting is the "gold standard" for peripheral nerve gap reconstruction. The pathological process of Wallerian degeneration from the time of acute injury to efficient...

journal_title：Scientific reports

authors： Ge J,Zhu S,Yang Y,Liu Z,Hu X,Huang L,Quan X,Wang M,Huang J,Li Y,Luo Z

更新日期：2016-12-23 00:00:00

abstract：:During capillary transit, red blood cells (RBCs) must exchange large quantities of CO2 and O2 in typically less than one second, but the degree to which this is rate-limited by diffusion through cytoplasm is not known. Gas diffusivity is intuitively assumed to be fast and this would imply that the intracellular path-l...

journal_title：Scientific reports

authors： Richardson SL,Swietach P

更新日期：2016-10-25 00:00:00

abstract：:In a short nanobearing system made from carbon nanotubes, the rotor with high rotational frequency may escape from the stator, which may cause a stability problem to the system of a nanodevice with such a nanobearing. In the present work, nanobearings with tri-walled nanotubes are investigated to reveal the conditions...

journal_title：Scientific reports

authors： Shi J,Liu LN,Cai K,Qin QH

更新日期：2017-07-28 00:00:00

abstract：:Long term multiple systemic antibiotics form the cornerstone in the treatment of bone and joint tuberculosis, often combined with local surgical eradication. Implanted carriers for local drug delivery have recently been introduced to overcome some of the limitations associated with conventional treatment strategies. I...

journal_title：Scientific reports

authors： Qayoom I,Verma R,Murugan PA,Raina DB,Teotia AK,Matheshwaran S,Nair NN,Tägil M,Lidgren L,Kumar A

更新日期：2020-08-24 00:00:00

abstract：:Evaluating and tuning the properties of two-dimensional (2D) materials is a major focus of advancing 2D science and technology. While many claim that the photonic properties of a 2D layer provide evidence that the material is "high quality", this may not be true for electronic performance. In this work, we deconvolute...

journal_title：Scientific reports

authors： Zhang K,Borys NJ,Bersch BM,Bhimanapati GR,Xu K,Wang B,Wang K,Labella M,Williams TA,Haque MA,Barnard ES,Fullerton-Shirey S,Schuck PJ,Robinson JA

更新日期：2017-12-05 00:00:00

abstract：:Zebrafish spontaneously regenerate the retina after injury. Although the gene expression profile has been extensively studied in this species during regeneration, this does not reflect protein function. To further understand the regenerative process in the zebrafish, we compared the proteomic profile of the retina dur...

journal_title：Scientific reports

authors： Eastlake K,Heywood WE,Tracey-White D,Aquino E,Bliss E,Vasta GR,Mills K,Khaw PT,Moosajee M,Limb GA

更新日期：2017-03-16 00:00:00

abstract：:Development of new antimicrobial agents is required against the causative agent for listeriosis, Listeria monocytogenes, as the number of drug resistant strains continues to increase. A promising target is the β-ketoacyl-acyl carrier protein synthase FabF, which participates in the catalysis of fatty acid synthesis an...

journal_title：Scientific reports

authors： Soares da Costa TP,Nanson JD,Forwood JK

更新日期：2017-01-03 00:00:00

abstract：:Polymersome nanoparticles (PMs) are attractive candidates for spatio-temporal controlled delivery of therapeutic agents. Although many studies have addressed cellular uptake of solid nanoparticles, there is very little data available on intracellular release of molecules encapsulated in membranous carriers, such as po...

journal_title：Scientific reports

authors： Scarpa E,Bailey JL,Janeczek AA,Stumpf PS,Johnston AH,Oreffo RO,Woo YL,Cheong YC,Evans ND,Newman TA

更新日期：2016-07-11 00:00:00

abstract：:CVB3 is a common human pathogen to be highly lethal to newborns and causes viral myocarditis and pancreatitis in adults. However, there is no vaccine available for clinical use. CVB3 capsid protein VP1 is an immunodominant structural protein, containing several B- and T-cell epitopes. However, immunization of mice wit...

journal_title：Scientific reports

authors： Qi X,Xiong S

更新日期：2017-02-02 00:00:00

abstract：:Stress-induced sensitization represents a process whereby prior exposure to severe stressors leaves animals or humans in a hyper-responsive state to further stressors. Indeed, this phenomenon is assumed to be the basis of certain stress-associated pathologies, including post-traumatic stress disorder and psychosis. On...

journal_title：Scientific reports

authors： Belda X,Nadal R,Armario A

更新日期：2016-08-11 00:00:00

abstract：:We report a method to generate a 3D motor neuron model with segregated and directed axonal outgrowth. iPSC-derived motor neurons are cultured in extracellular matrix gel in a microfluidic platform. Neurons extend their axons into an adjacent layer of gel, whereas dendrites and soma remain predominantly in the somal co...

journal_title：Scientific reports

authors： Spijkers XM,Pasteuning-Vuhman S,Dorleijn JC,Vulto P,Wevers NR,Pasterkamp RJ

更新日期：2021-01-22 00:00:00

abstract：:Altering mechanical compliance in load carriage structures has shown to reduce metabolic cost and accelerative forces of carrying weight. Currently, modifications to load carriage structures have been primarily targeted at vertical motion of the carried mass. No study to date has investigated altering load carriage co...

journal_title：Scientific reports

authors： Martin JP,Li Q

更新日期：2018-09-13 00:00:00

abstract：:Viral capsids are metastable structures that perform many essential processes; they also act as robust cages during the extracellular phase. Viruses can use multifunctional proteins to optimize resources (e.g., VP3 in avian infectious bursal disease virus, IBDV). The IBDV genome is organized as ribonucleoproteins (RNP...

journal_title：Scientific reports

authors： Mertens J,Casado S,Mata CP,Hernando-Pérez M,de Pablo PJ,Carrascosa JL,Castón JR

更新日期：2015-09-04 00:00:00

abstract：:The abundance and sinking of particulate black carbon (PBC) were examined for the first time in the western Arctic and Subarctic Oceans. In the central Arctic Ocean, high PBC concentrations with a mean of 0.021 ± 0.016 μmol L(-1) were observed in the marginal ice zone (MIZ). A number of parameters, including temperatu...

journal_title：Scientific reports

authors： Fang Z,Yang W,Chen M,Zheng M,Hu W

更新日期：2016-07-15 00:00:00

abstract：:Glucocorticoid receptor (GR) is a hormone-activated transcription regulatory protein involved in metabolism as well as adrenocortical responses to psychosocial stress. Ligand-activated GR localizes to the nucleus, where GR homodimers regulate gene transcription via direct binding to glucocorticoid response elements (G...

journal_title：Scientific reports

authors： Oasa S,Mikuni S,Yamamoto J,Kurosaki T,Yamashita D,Kinjo M

更新日期：2018-05-10 00:00:00

abstract：:Colorectal cancer is one of the main causes of cancer death worldwide, and novel biomarkers are urgently needed for its early diagnosis and treatment. The utilization of metabolomics to identify and quantify metabolites in body fluids may allow the detection of changes in their concentrations that could serve as diagn...

journal_title：Scientific reports

authors： Martín-Blázquez A,Díaz C,González-Flores E,Franco-Rivas D,Jiménez-Luna C,Melguizo C,Prados J,Genilloud O,Vicente F,Caba O,Pérez Del Palacio J

更新日期：2019-12-27 00:00:00

abstract：:Subduction requires the permanent generation of a bend fold in the subducting slab which mechanics is not well understood. Lithospheric bending of subducting slabs was traditionally considered to be accommodated by orthogonal flexure, generating extensional outer rise earthquakes responsible of the external arc elonga...

journal_title：Scientific reports

authors： Romeo I,Álvarez-Gómez JA

更新日期：2018-01-22 00:00:00

abstract：:When acids are supplied with an excess electron (or placed in an Ar or the more polarizable N2 matrix) in the presence of species such as NH3, the formation of ion-pairs is a likely outcome. Using density functional theory and first-principles calculations, however, we show that, without supplying an external electron...

journal_title：Scientific reports

authors： Varadwaj PR,Varadwaj A,Marques HM

更新日期：2019-07-23 00:00:00

abstract：:There are approximately 1 million cryptococcal infections per year among HIV+ individuals, resulting in nearly 625,000 deaths. Cryptococcus neoformans and Cryptococcus gattii are the two most common species that cause human cryptococcosis. These two species of Cryptococcus have differences in pathogenicity, diagnosis,...

journal_title：Scientific reports

authors： Hu S,Gu F,Chen M,Wang C,Li J,Yang J,Wang G,Zhou Z,Yang Y

更新日期：2020-07-27 00:00:00

abstract：:Surface-enhanced Raman spectroscopy (SERS) is considered a highly promising technology for different analytical purposes. The applications of SERS are still quite limited due its relatively poor quantitative repeatability and the fact that SERS is very sensitive to oxidation, which is a challenge especially with silve...

journal_title：Scientific reports

authors： Matikainen A,Nuutinen T,Itkonen T,Heinilehto S,Puustinen J,Hiltunen J,Lappalainen J,Karioja P,Vahimaa P

更新日期：2016-11-16 00:00:00

abstract：:Emerging infectious diseases such as chytridiomycosis and ranavirus infections are important contributors to the worldwide decline of amphibian populations. We reviewed data on 247 anuran mortality events in 43 States of the United States from 1999-2015. Our findings suggest that a severe infectious disease of tadpole...

journal_title：Scientific reports

authors： Isidoro-Ayza M,Lorch JM,Grear DA,Winzeler M,Calhoun DL,Barichivich WJ

更新日期：2017-08-31 00:00:00

abstract：:The prevalence and the distribution characteristics of corneal astigmatism (CA) and anterior segment biometry before surgery in Chinese congenital cataract (CC) patients are not completely understood. This study involved 400 CC patients from the Zhongshan Ophthalmic Center enrolled from February 2011 to August 2015. D...

journal_title：Scientific reports

authors： Lin D,Chen J,Liu Z,Wu X,Long E,Luo L,Lin Z,Li X,Zhang L,Chen H,Liu J,Chen W,Lin H,Liu Y

更新日期：2016-02-25 00:00:00

abstract：:Tissue ischemia results in an accumulation of lactate and local or systemic lactic acidosis. In nociceptive sensory neurons, lactate was reported to sensitize or activate the transient receptor potential ion channel TRPA1 and acid-sensing ion channels (ASICs). However, it is unclear how lactate modulates the TRPV1 reg...

journal_title：Scientific reports

authors： de la Roche J,Walther I,Leonow W,Hage A,Eberhardt M,Fischer M,Reeh PW,Sauer S,Leffler A

更新日期：2016-11-09 00:00:00

abstract：:Networks are widely used as a tool for describing diverse real complex systems and have been successfully applied to many fields. The distance between networks is one of the most fundamental concepts for properly classifying real networks, detecting temporal changes in network structures, and effectively predicting th...

journal_title：Scientific reports

authors： Shimada Y,Hirata Y,Ikeguchi T,Aihara K

更新日期：2016-10-11 00:00:00

abstract：:Early fruit development is crucial for crop production in tomato. After fertilization, the ovary undergoes cell division and cell expansion before maturation. Although the roles of regulatory signals such as hormone and carbohydrate during early fruit development have been studied, the spatial distribution and the seq...

journal_title：Scientific reports

authors： Zhang S,Xu M,Qiu Z,Wang K,Du Y,Gu L,Cui X

更新日期：2016-03-18 00:00:00

abstract：:Skeletal complications are common features of neonatal-onset multisystem inflammatory disease (NOMID), a disorder caused by NLRP3-activating mutations. NOMID mice in which NLRP3 is activated globally exhibit several characteristics of the human disease, including systemic inflammation and cartilage dysplasia, but the ...

journal_title：Scientific reports

authors： Wang C,Xu CX,Alippe Y,Qu C,Xiao J,Schipani E,Civitelli R,Abu-Amer Y,Mbalaviele G

更新日期：2017-07-07 00:00:00

abstract：:Novel strategies to target Trypanosoma brucei, Trypanosoma cruzi and Leishmania are urgently needed to generate better and safer drugs against Human African Trypanosomiasis, Chagas disease and Leishmaniasis, respectively. Here, we investigated the feasibility of selectively targeting in trypanosomatids the ubiquitin E...

journal_title：Scientific reports

authors： Boer DR,Bijlmakers MJ

更新日期：2019-11-07 00:00:00