Abstract：
:Long term multiple systemic antibiotics form the cornerstone in the treatment of bone and joint tuberculosis, often combined with local surgical eradication. Implanted carriers for local drug delivery have recently been introduced to overcome some of the limitations associated with conventional treatment strategies. In this study, we used a calcium sulphate hemihydrate (CSH)/nanohydroxyapatite (nHAP) based nanocement (NC) biomaterial as a void filler as well as a local delivery carrier of two standard of care tuberculosis drugs, Rifampicin (RFP) and Isoniazid (INH). We observed that the antibiotics showed different release patterns where INH showed a burst release of 67% and 100% release alone and in combination within one week, respectively whereas RFP showed sustained release of 42% and 49% release alone and in combination over a period of 12 weeks, respectively indicating different possible interactions of antibiotics with nHAP. The interactions were studied using computational methodology, which showed that the binding energy of nHAP with RFP was 148 kcal/mol and INH was 11 kcal/mol, thus varying substantially resulting in RFP being retained in the nHAP matrix. Our findings suggest that a biphasic ceramic based drug delivery system could be a promising treatment alternative to bone and joint TB.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Qayoom I,Verma R,Murugan PA,Raina DB,Teotia AK,Matheshwaran S,Nair NN,Tägil M,Lidgren L,Kumar Adoi
10.1038/s41598-020-70726-3subject
Has Abstractpub_date
2020-08-24 00:00:00pages
14128issue
1issn
2045-2322pii
10.1038/s41598-020-70726-3journal_volume
10pub_type
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