Abstract:
:Despite the promise for stem cell-based tissue engineering for regenerative therapy, slow and insufficient vascularization of large tissue constructs negatively impacts the survival and function of these transplanted cells. A combination of channeled porous silk scaffolds and prevascularization with endothelial cells was investigated to test the ability of this tissue engineering strategy to support rapid and extensive vascularization process. We report that hollow channels promote in vitro prevascularization by facilitating endothelial cell growth, VEGF secretion, and capillary-like tube formation. When implanted in vivo, the pre-established vascular networks in the hollow channel scaffolds anastomose with host vessels and exhibit accelerated vascular infiltration throughout the whole tissue construct, which provides timely and sufficient nutrients to ensure the survival of the transplanted stem cells. This tissue engineering strategy can promote the effective application of stem cell-based regeneration to improve future clinical applications.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Zhang W,Wray LS,Rnjak-Kovacina J,Xu L,Zou D,Wang S,Zhang M,Dong J,Li G,Kaplan DL,Jiang Xdoi
10.1016/j.biomaterials.2015.03.053subject
Has Abstractpub_date
2015-07-01 00:00:00pages
68-77eissn
0142-9612issn
1878-5905pii
S0142-9612(15)00331-2journal_volume
56pub_type
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