Abstract:
BACKGROUND:Somatostatin acts through five receptor subtypes (SSTRs 1-5). We aimed to investigate SSTRs mRNA expression and protein distribution in whole rat embryos, with special emphasis on the pancreas. MATERIAL AND METHODS:Rat embryos were collected on embryonal days 10, 11, 12, 14, 15, 17, 19, 21, and at birth. Presence of SSTRs was investigated with RT-PCR techniques and immunohistochemistry. RESULTS:There was no SSTR5 mRNA expression in the whole rat embryos. All SSTR1-5 proteins were observed at embryonal day 10, but the localization varied between the different subtypes. From day 11 to birth SSTRs protein presence increased with time in major structures such as skin and cartilage. It remained similar over time in the heart and liver. In the fetal pancreas mRNA expression of SSTR2 and 4 was detected at day 14, and there was an increase up to birth. Only SSTR1 protein co-localized to a higher extent with the islet hormones studied. SSTR2 was present in all islet endocrine cells except for β-cells. In contrast, the immunostaining for SSTR3-4 was co-localized with insulin and PP, and, finally, SSTR5 with glucagon and pancreatic polypeptide. In mRNA isolated from whole rat embryos SSTR1-2 and SSTR4 expression showed a peak at day 14, while SSTR3 mRNA was not present until day 15. CONCLUSION:The present data suggest a role for SSTRs during the development of the rat embryo. Subsequent functional studies may elucidate regulatory roles of specific SSTRs for the growth and differentiation of the pancreas as well as other organs.
journal_name
Ups J Med Scijournal_title
Upsala journal of medical sciencesauthors
Ludvigsen E,Carlsson C,Tiensuu Janson E,Sandler S,Stridsberg Mdoi
10.3109/03009734.2015.1035413subject
Has Abstractpub_date
2015-01-01 00:00:00pages
157-68issue
3eissn
0300-9734issn
2000-1967journal_volume
120pub_type
杂志文章abstract::Pain is one of the most feared problems for adolescents with cancer. Pain produces stress with negative physiological and psychological effects. Therefore, effective pain management during cancer treatment may influence the outcome. This study investigates variations in pain and quality of life during treatment in ado...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-020
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abstract::The patterns of fingertip prints (dermatoglyphics) in Swedish series of sexual offenders of law compared with common offenders of law and normal individuals were analysed. The dermatoglyphic patterns in common offenders of law did not differ from those in normal individuals. The group of sexual offenders of law showed...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
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journal_title:Upsala journal of medical sciences
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doi:10.3109/03009737809179108
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journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009737609179022
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abstract::In this study we describe an unusual complication in a patient suffering from chronic calcifying pancreatitis. The patient had a fistula between the common bile duct, the pancreatic duct, and the portal vein. He received supportive medical treatment and achieved long-term survival. A review of the literature including...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:The incidence of fentanyl-induced cough (FIC) during induction of general anesthesia varies around 40% and is undesirable. It increases intracranial, intraocular, and intra-abdominal pressures. This prospective, randomized, double-blind, placebo-controlled study evaluated the effect of dexmedetomidine (DEX) ...
journal_title:Upsala journal of medical sciences
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abstract::By means of an accurate immunoenzymatic assay, the prevalence was studied of antibodies to hepatitis C virus (HCV) in three different populations: 74 patients affected with hepatocellular carcinoma (HCC) on preexisting cirrhosis, 82 patients with liver cirrhosis but with no apparent neoplasm, and 70 control subjects, ...
journal_title:Upsala journal of medical sciences
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journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738409178460
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journal_title:Upsala journal of medical sciences
pub_type: 临床试验,杂志文章
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journal_title:Upsala journal of medical sciences
pub_type: 杂志文章,多中心研究
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更新日期:2016-08-01 00:00:00
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journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
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journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
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更新日期:1980-01-01 00:00:00
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更新日期:2020-11-01 00:00:00
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journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
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journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
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journal_title:Upsala journal of medical sciences
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.3109/03009738709178701
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journal_title:Upsala journal of medical sciences
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journal_title:Upsala journal of medical sciences
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abstract::Introduction: Carotid endarterectomy (CEA) is a surgical procedure used in the prevention of ischemic stroke. However, this procedure can cause complications of ischemia-reperfusion injury to the brain. Clusterin (CLU) is a cytoprotective chaperone protein that is released from neurons in response to various neurologi...
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journal_title:Upsala journal of medical sciences
pub_type: 杂志文章,评审
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journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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