Abstract：
:Secondary amyloidosis (AA amyloidosis) is a well known cause of nephrotic syndrome and renal failure. Several studies in patients with nephrotic syndrome have suggested a beneficial effect of angiotensin-converting enzyme inhibitors (ACEI). Angiotensin II (ATII) receptor antagonists effect on the long term is not known. In this study, we intended to study the effect of losartan, as an ATII receptor antagonist, on proteinuria and renal functions in patients with normotensive secondary amyloidosis. In total 44 patients with biopsy proven AA amyloidosis associated with nephrotic proteinuria were included. The first group of patients (n=22) was treated with losartan 50 mg/day. The second group of patients (n=22) did not receive any specific antiproteinuric treatment. Urinary protein loss was effectively lowered by losartan from 4.38 +/- 1.0 to 2.8 +/- 0.61 g/day (p<0.0001), whereas the control group showed a slight fall in proteinuria as 4.21 +/- 1.06 to 4.12 +/- 1.07 g/day (p = 0.176). Hypoalbuminemia improved significantly from 2.52 +/- 0.69 to 2.78 +/- 0.46 g/dl (p = 0.004), in the losartan group, whereas serum albumin had fallen in the control group from 2.44 +/- 0.57 to 2.27 +/- 0.41 (p = 0.041). Serum creatinine increased in the control group from 1.52 +/- 0.42 to 2.39 +/- 0.51 mg/dl (p<0.0001), and in the losartan group from 1.59 +/- 0.50 to 1.84 +/- 0.6 mg/dl (p<0.001), after 24 months of treatment. The ATII receptor blocker losartan is effective in protecting against the progression of nephropathy due to AA amyloidosis. Symptomatic treatment of proteinuria with losartan is therefore to be considered, especially with severe proteinuria even in normotensive patients.
journal_name
Ups J Med Scijournal_title
Upsala journal of medical sciencesauthors
Odabas AR,Cetinkaya R,Selcuk Y,Bilen Hdoi
10.3109/2000-1967-142keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
183-8issue
3eissn
0300-9734issn
2000-1967journal_volume
106pub_type
临床试验,杂志文章abstract：:Diabetes in the mother may cause disturbances in the chondrocyte development in the embryo. A rat model was used to investigate whether this was reflected in the production of proteoglycans by cells from two embryonic regions. One of these regions is resistant (limb bud) and the other susceptible (mandibular arch) to ...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009739009178574
更新日期：1990-01-01 00:00:00
abstract：:The effect of implantable drug delivery systems on computed tomography (CT) and magnetic resonance imaging (MRI) was investigated in a phantom and in two patients. The implantable systems of identical construction consisted either of medical grade titanium alloy or stainless steel. Images of a phantom showed artefacts...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009738909178560
更新日期：1989-01-01 00:00:00
abstract：:A thymolipoma in an 8-year-old boy is reported. The tumour had appeared on a routine chest X-ray as a broadened heart shadow and a peculiar right heart contour. Cardiac hypertrophy was suspected primarily. At thoracotomy a thymic tumour was found. ...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009737609179036
更新日期：1976-01-01 00:00:00
abstract：:Twenty-seven women with secondary amenorrhoea have been treated with pulsatile subcutaneous luteinising hormone releasing hormone (LHRH). Serial ultrasonic observations of increasing follicular diameters and changes in the size of the uterus have been recorded. The rate of the increase of the diameter of dominant foll...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009738409178460
更新日期：1984-01-01 00:00:00
abstract：:Alkaline phosphatase from calf intestinal mucosa dephosphorylated histone H1 and fibrinogen that had been phosphorylated with protein kinase C. The reaction velocity was dependent on the ionic strength of the buffer; decreasing with increasing concentration. The pH optimum was around 7, which is lower than pH-optima d...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009739109179262
更新日期：1991-01-01 00:00:00
abstract：:The tubuloglomerular feedback mechanism is highly activated in juxtamedullary nephrons and considered to play a major role in intrarenal regulation of glomerular filtration rate. The vasculature of juxtamedullary nephrons is highly vasoreactive with a high ability for vasodilation. This vasoreactivity is a prerequisit...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009739209179287
更新日期：1992-01-01 00:00:00
abstract：:Factors that may influence the water transport through the skin in infants on their first day of life were studied with a method based on determination of the vapour pressure gradient in the air layer close to the skin surface. The evaporation rate from the skin was found to vary with the site of measurement, ambient ...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009738109179207
更新日期：1981-01-01 00:00:00
abstract：:There has been only one reported case of neuromuscular scoliosis following chronic inflammatory demyelinating polyneuropathy (CIDP). However, no cases of scoliosis that were treated with surgery secondary to CIDP have been previously described. A 16-year-old boy with CIDP was consultant due to the progression of scoli...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009734.2012.757682
更新日期：2013-05-01 00:00:00
abstract：:For the corticotropin-releasing-hormone stimulation test the number of samplings and measurements are reduced to two--and the ratio between concentrations at 60 min and 0 min is calculated. The difference between the information given by absolute concentrations and ratio is negligible, but by using ratio, the influenc...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009739309179325
更新日期：1993-01-01 00:00:00
abstract：:In order to investigate the relevance of the currently used lower reference limit for S-Potassium in Danish hospital laboratories, analytical bias in the measurement of S-Potassium was compared with the lower reference limit in each of 52 Danish hospital laboratories. The acceptable bias range was estimated according ...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009739309179337
更新日期：1993-01-01 00:00:00
abstract：:The patterns of fingertip prints (dermatoglyphics) in Swedish series of sexual offenders of law compared with common offenders of law and normal individuals were analysed. The dermatoglyphic patterns in common offenders of law did not differ from those in normal individuals. The group of sexual offenders of law showed...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009739409179351
更新日期：1994-01-01 00:00:00
abstract：:The role of the sympathetic nerve system is still unknown in different types of hypertension. The procedure used in the evaluation of suspect renovascular hypertension has been revised in such a way that renal blood flow, renal arterial blood pressure and plasma renin activity in renal vein could be determined prior t...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009737609179031
更新日期：1976-01-01 00:00:00
abstract：:Introduction: Carotid endarterectomy (CEA) is a surgical procedure used in the prevention of ischemic stroke. However, this procedure can cause complications of ischemia-reperfusion injury to the brain. Clusterin (CLU) is a cytoprotective chaperone protein that is released from neurons in response to various neurologi...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.1080/03009734.2019.1646359
更新日期：2019-08-01 00:00:00
abstract：:A patient with relapsing polychondritis developed a progressive destruction of tracheal cartilage despite treatment with immunosuppressive and cytotoxic agents. Cyclosporin A therapy was instituted and has been continued for more than two years, concomitant with a steady improvement and remission of the disease. Durin...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009738509178637
更新日期：1985-01-01 00:00:00
abstract：:In experimental studies using a 0.1 mm focal sport tube, rare-eath screens, Cornex 4 film and diluted contrast agent (120 mgI/ml), 6Xmagnification detail in the walls of major arteries that could not be identified with standard radiography or 3Xmagnification. The method is applicable to studies of arteriosclerotic cha...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009737509179004
更新日期：1975-01-01 00:00:00
abstract：:During the last decade, capillary electrophoresis (CE) has emerged as an interesting alternative to traditional analysis of serum, plasma and urine proteins by agarose gel electrophoresis. Initially there was a considerable difference in resolution between the two methods but the quality of CE has improved significant...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/2000-1967-219
更新日期：2008-01-01 00:00:00
abstract：:In this review the advantages of the gonadotropin-releasing hormone agonist (GnRHa) trigger are discussed beyond those immediately associated with ovarian hyperstimulation syndrome (OHSS) prevention. The GnRHa trigger concept has sparked the development of novel protocols, enriching the assisted reproductive technolog...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.1080/03009734.2020.1737599
更新日期：2020-05-01 00:00:00
abstract：:There are few reports concerning the gait characteristics of sciatic nerve palsy. Four cases, one with complete palsy and three with incomplete palsy, are presented. Complete palsy (case 1) was due to sacrifice of the sciatic nerve in a wide excision for chondrosarcoma in the left ischium. Incomplete palsy (cases 2, 3...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/2000-1967-116
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:Women previously giving birth with cesarean section have an increased risk of postpartum hemorrhage (PPH) and retained placenta. The objective of this study was to determine if anterior placental location increased the risk of PPH and retained placenta in such women. MATERIALS AND METHODS:We performed a pros...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.1080/03009734.2017.1356405
更新日期：2017-08-01 00:00:00
abstract：:The effect of a peroral dose of olsalazine sodium on the migrating motor complexes (MMC) in the upper small bowel was studied by manometry in nine healthy volunteers during fasting. Recordings were obtained from the duodenum and/or the upper jejunum for 4.0 - 7.5 h. During total baseline observation periods of 30 h, f...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009738709178694
更新日期：1987-01-01 00:00:00
abstract：:Cytosolic carbonic anhydrases CAI, CAII, and CAIII from liver, and CAII, and CAIII from muscle of adult male Sprague-Dawley rats were purified to homogeneity. CAIII from liver and muscle had the same amino acid composition and were immunochemically similar. Their kinetic properties at 0 degrees C were also similar. Km...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/2000-1967-131
更新日期：2002-01-01 00:00:00
abstract：:Platelet-derived growth factor B (PDGF-B) is a growth factor promoting and regulating cell migration, proliferation, and differentiation, involved in both developmental processes and in maintaining tissue homeostasis under strict regulation. What are the implications of prolonged or uncontrolled growth factor signalin...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009734.2012.654860
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Open reduction and internal fixation using an interlocking plate system has gained popularity for the treatment of dorsally displaced distal radius fractures. PURPOSE:To evaluate the functional and radiological results of treating unstable distal radius fractures with the volar locking plate. PATIENTS AND ...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009734.2011.594183
更新日期：2011-11-01 00:00:00
abstract：:In this report, we present a 68-year-old man with rice body formation in the flexor tendon sheath of the fingers without any inflammatory diseases such as tuberculosis or rheumatoid arthritis. The patient visited our institute in March 2004 with a one-month history of swelling and pain of the right distal forearm. Lab...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.1080/03009730902931408
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Autologous chondrocyte implantation (ACI) is considered a promising choice for the treatment of cartilage defects. However, the application of ACI to osteoarthritic patients is, in general, contraindicated. The purpose of this study is to evaluate the efficiency of three-dimensionally structured ACI (3D-ACI;...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009734.2011.552812
更新日期：2011-05-01 00:00:00
abstract：:Post-heparin plasma hepatic triglyceride lipase (H-TGL) and lipoprotein lipase (LPL) activities were 8-34 and 3.5-21 (range) mu mol/ml/hr respectively in males with normal serum lipid concentrations. In females the corresponding values were 4-25 and 4-16 mu mol/ml/hr. No significant differences were observed between a...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009737909179158
更新日期：1979-01-01 00:00:00
abstract：:This study was undertaken to evaluate the utility of a modified technique of triplex scanning of the lower extremity arteries in 20 subjects without any clinical signs of arterial disease. The distal aorta and iliac arteries were examined with the subject in supine position and lying slightly on the opposite side. By ...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009739609178917
更新日期：1996-01-01 00:00:00
abstract：OBJECTIVES:The incidence of fentanyl-induced cough (FIC) during induction of general anesthesia varies around 40% and is undesirable. It increases intracranial, intraocular, and intra-abdominal pressures. This prospective, randomized, double-blind, placebo-controlled study evaluated the effect of dexmedetomidine (DEX) ...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章,随机对照试验
doi：10.3109/03009734.2011.629749
更新日期：2012-03-01 00:00:00
abstract：:Vasospastic reactions to cold have been suggested to be related to altered blood rheology, as has been reported in both primary (PVD) and traumatic (TVD) vasospastic disease. Measurements of whole blood viscosity, plasma viscosity, erythrocyte deformability and finger systolic pressure (FSP) were performed in 18 patie...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009738509178639
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVES:To estimate the possible economic benefit of a sequential testing strategy with NT-proBNP to reduce the number of echocardiographies. METHODS:Retrospective study in a third-party payer perspective. The costs were calculated from three Swedish counties: Blekinge, Östergötland, and Uppland. Two cut-off levels...
journal_title：Upsala journal of medical sciences
pub_type： 杂志文章
doi：10.3109/03009734.2012.751471
更新日期：2013-05-01 00:00:00
