Abstract:
:Platelet-derived growth factor B (PDGF-B) is a growth factor promoting and regulating cell migration, proliferation, and differentiation, involved in both developmental processes and in maintaining tissue homeostasis under strict regulation. What are the implications of prolonged or uncontrolled growth factor signaling in vivo, and when does a growth factor such as PDGF-B become an oncogene? Under experimental conditions, PDGF-B induces proliferation and causes tumor induction. It is not known whether these tumors are strictly a PDGF-B-driven proliferation of cells or associated with secondary genetic events such as acquired mutations or methylation-mediated gene silencing promoting neoplasia. If PDGF-B-driven tumorigenesis was only cellular proliferation, associated changes in gene expression would thus be correlated with proliferation and not associated with secondary events involved in tumorigenesis and neoplastic transformation such as cycle delay, DNA damage response, and cell death. Changes in gene expression might be expected to be reversible, as is PDGF-B-driven proliferation under normal circumstances. Since PDGF signaling is involved in oligodendrocyte progenitor cell differentiation and maintenance, it is likely that PDGF-B stimulates proliferation of a pool of cells with that phenotype, and inhibition of PDGF-B signaling would result in reduced expression of oligodendrocyte-associated genes. More importantly, inhibition of PDGF signaling would be expected to result in reversion of genes induced by PDGF-B accompanied by a decrease in proliferation. However, if PDGF-B-driven tumorigenesis is more than simply a proliferation of cells, inhibition of PDGF signaling may not reverse gene expression or halt proliferation. These fundamental questions concerning PDGF-B as a potential oncogene have not been resolved.
journal_name
Ups J Med Scijournal_title
Upsala journal of medical sciencesauthors
Lindberg N,Holland ECdoi
10.3109/03009734.2012.654860subject
Has Abstractpub_date
2012-05-01 00:00:00pages
92-8issue
2eissn
0300-9734issn
2000-1967journal_volume
117pub_type
杂志文章abstract:OBJECTIVES:To estimate the possible economic benefit of a sequential testing strategy with NT-proBNP to reduce the number of echocardiographies. METHODS:Retrospective study in a third-party payer perspective. The costs were calculated from three Swedish counties: Blekinge, Östergötland, and Uppland. Two cut-off levels...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2012.751471
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Atherosclerosis is a generalized disease of the arterial vasculature; among thus it manifests in the descending aorta and the coronary arteries. We tested whether known risk factors, the coronary flow velocity reserve and the grade of aortic atherosclerosis detected by transoesophageal echocardiography in th...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-097
更新日期:2007-01-01 00:00:00
abstract::In early ARDS (Adult Respiratory Distress Syndrome) and other inflammatory pulmonary disorders the lung might benefit from a high local deposition of an active drug, in order to optimize the local concentration without systemic side effects. In this methodological study we used pigs under controlled ventilation. The s...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009739009178581
更新日期:1990-01-01 00:00:00
abstract::A material comprising all children in Sweden with acute lymphoblastic leukemia diagnosed in the years 1973-80 was analysed statistically. The total number of children was 505. Studies were made of 38 different variables, using frequency tables, cross tables, life table studies (1) and linear regression analysis accord...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738209178424
更新日期:1982-01-01 00:00:00
abstract::Abstract Pyogenic spondylitis is a common infectious disease caused by various microorganisms. It is difficult to predict the infecting microorganism at the time of initiation of treatment. Pneumonia is generally clarified into community or hospital-acquired types based on where the infection was acquired, and the i...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2012.687406
更新日期:2012-11-01 00:00:00
abstract::There has been only one reported case of neuromuscular scoliosis following chronic inflammatory demyelinating polyneuropathy (CIDP). However, no cases of scoliosis that were treated with surgery secondary to CIDP have been previously described. A 16-year-old boy with CIDP was consultant due to the progression of scoli...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2012.757682
更新日期:2013-05-01 00:00:00
abstract::Familial aggregation of patients with ovarian carcinoma is unusual. A family with four affected members in three consecutive generations is described. The tumors were all of the serous papillary adenocarcinoma type. The pattern of appearance of the malignant disorder in the present family may be explained as the resul...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009737609179047
更新日期:1976-01-01 00:00:00
abstract::Secondary osteosarcoma arising after the treatment of hematologic malignancies other than Hodgkin's lymphoma is rare. We report two cases of secondary osteosarcoma arising after treatment for childhood hematologic malignancies (non-Hodgkin's lymphoma and lymphoblastic leukemia). A 10-year-old boy, at the age of 3, was...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009730903177340
更新日期:2009-01-01 00:00:00
abstract::The morphological changes in the liver and pancreas during the first 12 hours in the acute afferent loop syndrome were studied in rats with a Billroth II gastric resection. Two essentially different types of changes were found in the pancreas. One was a coagulative necrosis without an inflammatory reaction, which has ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009737609179023
更新日期:1976-01-01 00:00:00
abstract::In this study we describe an unusual complication in a patient suffering from chronic calcifying pancreatitis. The patient had a fistula between the common bile duct, the pancreatic duct, and the portal vein. He received supportive medical treatment and achieved long-term survival. A review of the literature including...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章,评审
doi:10.3109/2000-1967-059
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Minimally invasive laparoscopic radical prostatectomy (LRP) has proven equally effective as open surgery in terms of cancer control and peroperative complication rate with less bleeding and postoperative pain. However, long-term follow-up data after LRP are scarce, especially as related to quality of life (Q...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2013.868560
更新日期:2014-03-01 00:00:00
abstract::The bisphosphonates are potent inhibitors of osteoclastic bone resorption that mainly have been used for treatment of hypercalcaemia secondary to malignancy. We have performed a controlled dose-finding study of oral pamidronate that was given to 60 patients with a history of fracture of the distal forearm, an enhanced...
journal_title:Upsala journal of medical sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/03009739109179272
更新日期:1991-01-01 00:00:00
abstract::The occurrence of bacteriuria in spinal cord injured patients with neurogenic bladder dysfunction who used clean intermittent catheterisation to empty their bladders was studied in order to examine cut-off concentration breakpoints for significant bacteriuria in this group of patients using procedures of the European ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-107
更新日期:2004-01-01 00:00:00
abstract::Numerous false positive findings are a problem in computed tomography based lung cancer screening trials. The potential patient-related variables that could predict the existence of such lung nodules were studied. 526 construction workers (age 38-81 yrs.) previously screened with spiral computed tomography were evalua...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-242
更新日期:2008-01-01 00:00:00
abstract::A patient with relapsing polychondritis developed a progressive destruction of tracheal cartilage despite treatment with immunosuppressive and cytotoxic agents. Cyclosporin A therapy was instituted and has been continued for more than two years, concomitant with a steady improvement and remission of the disease. Durin...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738509178637
更新日期:1985-01-01 00:00:00
abstract::Pain is one of the most feared problems for adolescents with cancer. Pain produces stress with negative physiological and psychological effects. Therefore, effective pain management during cancer treatment may influence the outcome. This study investigates variations in pain and quality of life during treatment in ado...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-020
更新日期:2006-01-01 00:00:00
abstract::The patterns of fingertip prints (dermatoglyphics) in Swedish series of sexual offenders of law compared with common offenders of law and normal individuals were analysed. The dermatoglyphic patterns in common offenders of law did not differ from those in normal individuals. The group of sexual offenders of law showed...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009739409179351
更新日期:1994-01-01 00:00:00
abstract::Inverse ratio ventilation (IRV) is commonly used in clinical practice. Several studies have used IRV in order to recruit collapsed alveoli. In a randomised trial in twelve surfactant depleted piglets, the lungs were ventilated with sufficient positive end-expiratory pressure (PEEP) to prevent end-expiratory collapse, ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009739609178925
更新日期:1996-01-01 00:00:00
abstract::Oxyhemoglobin, methemoglobin and hematin were found to catalyze xanthine-oxidase-induced peroxidation of phospholipid liposomes, while oxy- and metmyoglobin were inactive in this respect. The peroxidation was inhibited by desferrioxamine and by EDTA. Peroxidation catalyzed by 0.4 microM oxyhemoglobin was decreased by ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738809178547
更新日期:1988-01-01 00:00:00
abstract::This study was undertaken to evaluate the utility of a modified technique of triplex scanning of the lower extremity arteries in 20 subjects without any clinical signs of arterial disease. The distal aorta and iliac arteries were examined with the subject in supine position and lying slightly on the opposite side. By ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009739609178917
更新日期:1996-01-01 00:00:00
abstract::Bile salt sulphation in primary biliary cirrhosis was studied by measurements of the liver bile salt sulphotransferase levels in 16 patients. Although the enzyme activity varied among the patients it did not correlate with the severity of cholestasis. Furthermore, the mean bile salt sulphotransferase magnitude in pati...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738309178432
更新日期:1983-01-01 00:00:00
abstract::Thirteen healthy women (age 24-44 yrs) were studied during their menstrual cycle. Samples were taken 2-3 times weekly for six consecutive weeks. Plasma concentrations of oestradiol and progesterone were determined in each blood sample and only women found to be ovulatory were included. From the hormone data the cycles...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738909178559
更新日期:1989-01-01 00:00:00
abstract:AIM:To investigate how individuals fulfilling the Rome II criteria for irritable bowel syndrome (IBS) spontaneously described their symptoms. METHOD:From a general population, 1,244 randomly sampled adults were asked to describe their gastrointestinal symptoms (if any) verbally, in their own words, at a semi-structure...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2015.1040529
更新日期:2015-01-01 00:00:00
abstract::22 patients with untreated, essential hypertension (diastolic blood-pressure greater than or equal to 140 mmHg) and in most cases also showing neurological symptoms were given a single oral dose of 400 mg labetalol. All patients displayed a gradual decrease of the blood-pressure down to a diastolic pressure about 110 ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738709178680
更新日期:1987-01-01 00:00:00
abstract::The acute phase reaction is an unspecific response to inflammatory stimuli characterized by alterations in the concentration of several plasma proteins. It is of great clinical value to monitor the inflammatory state in patients with rheumatoid arthritis. The erythrocyte sedimentation rate (ESR) and C-reactive protein...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009739809178943
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:The size of inhaled particles influences where they deposit and theoretically should be important for the development of airway inflammation and responsiveness. Our aim was to assess if sensitization to smaller-sized aeroallergens relates to higher prevalence of treated asthma, increased airway responsivenes...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2015.1109569
更新日期:2016-01-01 00:00:00
abstract::The purpose of this study is to verify that compound muscle action potentials (CMAPs) generated a stationary potential and to examine extension of the CMAPs away from the stimulated muscle. A referential derivation and/or bipolar derivation to record the stationary potentials were carried out following tibial nerve st...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-103
更新日期:2004-01-01 00:00:00
abstract::Secondary amyloidosis (AA amyloidosis) is a well known cause of nephrotic syndrome and renal failure. Several studies in patients with nephrotic syndrome have suggested a beneficial effect of angiotensin-converting enzyme inhibitors (ACEI). Angiotensin II (ATII) receptor antagonists effect on the long term is not know...
journal_title:Upsala journal of medical sciences
pub_type: 临床试验,杂志文章
doi:10.3109/2000-1967-142
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Open reduction and internal fixation using an interlocking plate system has gained popularity for the treatment of dorsally displaced distal radius fractures. PURPOSE:To evaluate the functional and radiological results of treating unstable distal radius fractures with the volar locking plate. PATIENTS AND ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2011.594183
更新日期:2011-11-01 00:00:00
abstract::In order to investigate the relevance of the currently used lower reference limit for S-Potassium in Danish hospital laboratories, analytical bias in the measurement of S-Potassium was compared with the lower reference limit in each of 52 Danish hospital laboratories. The acceptable bias range was estimated according ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009739309179337
更新日期:1993-01-01 00:00:00