Tubular proteinuria during treatment with cyclosporin A--a case report.

Abstract:

:A patient with relapsing polychondritis developed a progressive destruction of tracheal cartilage despite treatment with immunosuppressive and cytotoxic agents. Cyclosporin A therapy was instituted and has been continued for more than two years, concomitant with a steady improvement and remission of the disease. During the treatment period an increased urinary excretion of beta 2-microglobulin was measured, indicating renal tubular damage. The tubular proteinuria preceded an elevation of serum creatinine and a drop in creatinine-clearance. Thus, beta 2-microglobulin might be a sensitive indicator of nephrotoxicity and of value for the evaluation of the long-term side effects of Cyclosporin A particularly in patients with extrarenal disease.

journal_name

Ups J Med Sci

authors

Svenson KL,Wibell LB

doi

10.3109/03009738509178637

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

43-8

issue

1

eissn

0300-9734

issn

2000-1967

journal_volume

90

pub_type

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