Abstract:
:A patient with relapsing polychondritis developed a progressive destruction of tracheal cartilage despite treatment with immunosuppressive and cytotoxic agents. Cyclosporin A therapy was instituted and has been continued for more than two years, concomitant with a steady improvement and remission of the disease. During the treatment period an increased urinary excretion of beta 2-microglobulin was measured, indicating renal tubular damage. The tubular proteinuria preceded an elevation of serum creatinine and a drop in creatinine-clearance. Thus, beta 2-microglobulin might be a sensitive indicator of nephrotoxicity and of value for the evaluation of the long-term side effects of Cyclosporin A particularly in patients with extrarenal disease.
journal_name
Ups J Med Scijournal_title
Upsala journal of medical sciencesauthors
Svenson KL,Wibell LBdoi
10.3109/03009738509178637subject
Has Abstractpub_date
1985-01-01 00:00:00pages
43-8issue
1eissn
0300-9734issn
2000-1967journal_volume
90pub_type
杂志文章abstract::Early discharge, defined as hospital leave 24-48 hours after birth, was introduced at Falun Hospital in 1984. 164 women interested in participating in an evaluative study of the program were randomly allocated in late pregnancy to an Experimental group (EG) offered early discharge, and a Control group (CG) offered the...
journal_title:Upsala journal of medical sciences
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.3109/03009738709178701
更新日期:1987-01-01 00:00:00
abstract::Abstract Pyogenic spondylitis is a common infectious disease caused by various microorganisms. It is difficult to predict the infecting microorganism at the time of initiation of treatment. Pneumonia is generally clarified into community or hospital-acquired types based on where the infection was acquired, and the i...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2012.687406
更新日期:2012-11-01 00:00:00
abstract::Transforming growth factor-β (TGF-β) elicits both tumor-suppressive and tumor-promoting functions during cancer progression. Here, we describe the tumor-promoting functions of TGF-β and how these functions play a role in cancer progression. Normal epithelial cells undergo epithelial-mesenchymal transition (EMT) throug...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章,评审
doi:10.3109/03009734.2011.638729
更新日期:2012-05-01 00:00:00
abstract::A thymolipoma in an 8-year-old boy is reported. The tumour had appeared on a routine chest X-ray as a broadened heart shadow and a peculiar right heart contour. Cardiac hypertrophy was suspected primarily. At thoracotomy a thymic tumour was found. ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009737609179036
更新日期:1976-01-01 00:00:00
abstract:AIM:The purpose was to assess the direct costs of screening for high blood pressure and blood glucose in dental care and of follow-up in primary health care and, based on these data, arrive at a prediction function. Study population. All subjects coming for routine check-ups at three dental health clinics were invited ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章,多中心研究
doi:10.3109/03009734.2013.818599
更新日期:2013-11-01 00:00:00
abstract::Introduction: Carotid endarterectomy (CEA) is a surgical procedure used in the prevention of ischemic stroke. However, this procedure can cause complications of ischemia-reperfusion injury to the brain. Clusterin (CLU) is a cytoprotective chaperone protein that is released from neurons in response to various neurologi...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.1080/03009734.2019.1646359
更新日期:2019-08-01 00:00:00
abstract::SAPHO syndrome is a group of bone and joint abnormalities associated with skin lesions. A 29-year-old male presented with severe acne on his trunk and anterior chest wall, right knee and foot pain. Radiographs and magnetic resonance images showed hyperostosis in the sternocostoclavicular region, sclerosis of one-third...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-045
更新日期:2006-01-01 00:00:00
abstract::Determinations were made of the 2-hour 22Na space and the 1 and 2 hour 51Cr EDTA spaces in a number of tissues. In regions where the two 51Cr-EDTA spaces were similar and smaller than or similar to the 22Na space the former spaces were regarded as measures of the extra-cellular volume. Using previously published data ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009737909179148
更新日期:1979-01-01 00:00:00
abstract::In this study we describe an unusual complication in a patient suffering from chronic calcifying pancreatitis. The patient had a fistula between the common bile duct, the pancreatic duct, and the portal vein. He received supportive medical treatment and achieved long-term survival. A review of the literature including...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章,评审
doi:10.3109/2000-1967-059
更新日期:2006-01-01 00:00:00
abstract::Local heat trauma was induced in rats with alloxan diabetes of 3 days duration. Zinc and copper concentrations in serum, liver, heart and pancreas were estimated. After traumatization there was a decrease of the serum zinc concentration in all animals. The lowest concentration was found in the diabetic animals. Serum ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738009179172
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Non-contrast computed tomography (NCT) has become an important diagnostic tool in acute abdominal pain, but the drawback is the increased radiation dose compared to abdominal plain film (APF). PURPOSE:To evaluate whether NCT, including low-dose computed tomography (LDCT, using 50 mAs), provides more diagnos...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009730903294871
更新日期:2010-05-01 00:00:00
abstract::In order to investigate the relevance of the currently used lower reference limit for S-Potassium in Danish hospital laboratories, analytical bias in the measurement of S-Potassium was compared with the lower reference limit in each of 52 Danish hospital laboratories. The acceptable bias range was estimated according ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009739309179337
更新日期:1993-01-01 00:00:00
abstract::A method for estimation of the erythrocyte sedimentation from repeated measurements during the initial part of the sedimentation phase is described. Based on the measurements between 18 and 24 minutes after the beginning of the reaction, the sedimentation at 60 minutes is estimated. The estimate is highly correlated t...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009739409179362
更新日期:1994-01-01 00:00:00
abstract::Diabetes in the mother may cause disturbances in the chondrocyte development in the embryo. A rat model was used to investigate whether this was reflected in the production of proteoglycans by cells from two embryonic regions. One of these regions is resistant (limb bud) and the other susceptible (mandibular arch) to ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009739009178574
更新日期:1990-01-01 00:00:00
abstract::Isokinetic torque of the knee and elbow during maximal extension and flexion and isometric strength of the handgrip, as well as balance and some circulatory variables, were tested in 37 patients one year after an acute stroke. Correlations with locomotion, household work and other activities of daily living (ADL) were...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738209178405
更新日期:1982-01-01 00:00:00
abstract::An investigation was made of 150 women who were diagnosed at the Department of Obstetrics and Gynaecology, University Hospital, Uppsala in 1964-68 as having toxaemia of pregnancy. Eleven had eclampsia and the remainder pre-eclampsia. Toxaemia occurred in 0.88% (average) of all parturients during the study period. Some...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009737809179108
更新日期:1978-01-01 00:00:00
abstract:AIM:The aim of this study was to examine the situation for elderly patients with diabetes living in nursing homes with regard to diabetes treatment, clinical variables, and vascular complications associated with diabetes. A second aim was to evaluate if the patients were at risk of hypoglycaemia. METHODS:This was a cr...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章,多中心研究
doi:10.1080/03009734.2016.1198441
更新日期:2016-08-01 00:00:00
abstract::The vertebral end-plates and the epiphyses from the lumbar region of the spine in juvenile pigs were studied. Cell density of the hyaline cartilage of the vertebral bodies was measured as well as cartilage thickness. The relative bone content in the region of the nucleus pulposus was calculated. A certain negative int...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738509178481
更新日期:1985-01-01 00:00:00
abstract::The present investigation on 20 patients after total hip replacement surgery has confirmed that the posttraumatic increase of the fibrinolysis inhibition activity (FIA) in serum and plasminogen-depleted serum is due to the primary fibrinolysis inhibitor (PFI, alpha 2-antiplasmin). This protein exists in at least two f...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738209178409
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Autologous chondrocyte implantation (ACI) is considered a promising choice for the treatment of cartilage defects. However, the application of ACI to osteoarthritic patients is, in general, contraindicated. The purpose of this study is to evaluate the efficiency of three-dimensionally structured ACI (3D-ACI;...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2011.552812
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Atherosclerosis is a generalized disease of the arterial vasculature; among thus it manifests in the descending aorta and the coronary arteries. We tested whether known risk factors, the coronary flow velocity reserve and the grade of aortic atherosclerosis detected by transoesophageal echocardiography in th...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-097
更新日期:2007-01-01 00:00:00
abstract::During the last decade, capillary electrophoresis (CE) has emerged as an interesting alternative to traditional analysis of serum, plasma and urine proteins by agarose gel electrophoresis. Initially there was a considerable difference in resolution between the two methods but the quality of CE has improved significant...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-219
更新日期:2008-01-01 00:00:00
abstract::The lipid metabolism of isolated mouse pancreatic islets, which had been cultured for one week at 3.3 or 16.7 mM glucose, was examined in short-term experiments performed at the end of the culture period. It was found that: a) high-glucose cultured islets oxidized palmitate at a higher rate: and b) both groups of cult...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738109179210
更新日期:1981-01-01 00:00:00
abstract::There are few reports concerning the gait characteristics of sciatic nerve palsy. Four cases, one with complete palsy and three with incomplete palsy, are presented. Complete palsy (case 1) was due to sacrifice of the sciatic nerve in a wide excision for chondrosarcoma in the left ischium. Incomplete palsy (cases 2, 3...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-116
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Two standard sets of criteria are used to evaluate the tumor response of hepatocellular carcinoma (HCC): RECIST (Response Evaluation Criteria in Solid Tumors) and modified RECIST (mRECIST). The purpose was to compare two tumor response evaluation criteria, RECIST version 1.1 and mRECIST, for HCC treated usin...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章,多中心研究
doi:10.3109/03009734.2012.729104
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:It has recently been reported that patient selection has a strong impact on the agreement between glomerular filtration rate (GFR) estimates from serum cystatin C and creatinine. The aim of our study was to evaluate the effect of creatinine production rate (CPR) on this subject. MATERIAL AND METHODS:GFR was...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2012.696154
更新日期:2012-11-01 00:00:00
abstract:INTRODUCTION:Accumulating evidence suggests that enhanced inflammatory responses contribute to the pathogenesis of postoperative cognitive dysfunction (POCD). Blood transfusion can trigger an enhancement of acute inflammatory responses. Therefore, we hypothesized that perioperative blood transfusion is associated with ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2013.873502
更新日期:2014-08-01 00:00:00
abstract::Since 1975 Sweden has had a patient insurance system to compensate patients for health-related injuries. The system was initially based on a voluntary patient insurance solution, but in 1997 it was replaced by the Patient Insurance Act. The current Act covers both physical and mental injuries. Although about 9,000-10,...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009730903350749
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Diabetic patients exhibit platelet hyperreactivity, which renders them resistant to antithrombotic treatments. We aimed to investigate the prevalence and predictors of aspirin resistance in diabetic patients. MATERIAL AND METHODS:A total of 93 diabetic and 37 non-diabetic participants were included into the...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2013.861549
更新日期:2014-03-01 00:00:00
abstract::This study was undertaken to evaluate the utility of a modified technique of triplex scanning of the lower extremity arteries in 20 subjects without any clinical signs of arterial disease. The distal aorta and iliac arteries were examined with the subject in supine position and lying slightly on the opposite side. By ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009739609178917
更新日期:1996-01-01 00:00:00