Anti-HCV antibodies and hepatocellular carcinoma. Relationship in a medium-risk population.

Abstract:

:By means of an accurate immunoenzymatic assay, the prevalence was studied of antibodies to hepatitis C virus (HCV) in three different populations: 74 patients affected with hepatocellular carcinoma (HCC) on preexisting cirrhosis, 82 patients with liver cirrhosis but with no apparent neoplasm, and 70 control subjects, hospitalized for various conditions, of internal medicine or geriatric interest. 70.2% of HCC patients exhibited anti-HBC antibodies, versus 47.5% of cirrhotic subjects with no tumor and 7.1% of controls. Such results suggest the possible role of HCV in the etiopathogenesis of HCC, and its possible synergy with other agents-e.g., hepatitis B virus, alcohol--in causing chronically injured hepatocytes to become neoplastic.

journal_name

Ups J Med Sci

authors

Porta C,Moroni M,Nastasi G,Ricci G,Casagranda I

doi

10.3109/03009739209179300

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

261-6

issue

3

eissn

0300-9734

issn

2000-1967

journal_volume

97

pub_type

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