Abstract:
:Previous experiments have demonstrated that neuronal cells within pancreatic islets survive the isolation procedure and constitute an integral part of transplanted pancreatic islets. The aim of the present study was to investigate to what extent immunosuppressive drugs affects the acute survival of intra-islet neurons after pancreatic islet transplantation. For this purpose, C57BL/6 mice were syngeneically transplanted with 250 islets under the renal capsule. The animals were treated for 7 consecutive days with subcutaneous injections of cyclosporin, tacrolimus or vehicle. After this, the animals were killed and the grafts were removed, fixed and stained for the presence of the neuron-specific protein PGP 9.5. The number of nerves were then morphologically quantitated. No differences between the experimental groups were seen, and the number of nervous elements were approximately 5 per mm2 in all animals. It is concluded that immunosuppressive treatment does not affect the acute survival of graft neurons after experimental islet transplantation.
journal_name
Ups J Med Scijournal_title
Upsala journal of medical sciencesauthors
Präst I,Carlsson PO,Jansson L,Mattsson Gdoi
10.3109/2000-1967-167keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
145-50issue
2eissn
0300-9734issn
2000-1967journal_volume
106pub_type
杂志文章abstract::For staging of Hodgkin's disease 45 patients underwent lymphography and abdominal computed tomography (CT); in 31 of them ultrasound examination was also performed. In cases of retroperitoneal lymph node enlargement lymphography and CT are diagnostically equivalent, whereas the poorer resolution of ultrasound reduces ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738409179500
更新日期:1984-01-01 00:00:00
abstract::Gastrointestinal transit was measured in non-obese diabetic (NOD) mice, as an animal model of human diabetes type 1, and in obese diabetic mice, as an animal model of human diabetes type 2. The endocrine cells known to correlate to gastrointestinal transit, namely secretin, serotonin, Peptide YY (PYY) and enteroglucag...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-139
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Autologous chondrocyte implantation (ACI) is considered a promising choice for the treatment of cartilage defects. However, the application of ACI to osteoarthritic patients is, in general, contraindicated. The purpose of this study is to evaluate the efficiency of three-dimensionally structured ACI (3D-ACI;...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2011.552812
更新日期:2011-05-01 00:00:00
abstract::The morphological changes in the liver and pancreas during the first 12 hours in the acute afferent loop syndrome were studied in rats with a Billroth II gastric resection. Two essentially different types of changes were found in the pancreas. One was a coagulative necrosis without an inflammatory reaction, which has ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009737609179023
更新日期:1976-01-01 00:00:00
abstract::Sertoli-Leydig cell tumours are rare sex stromal tumours with an incidence of < 0.5% of all ovarian tumours. Most frequently this tumour occurs in young women with a history of amenorrhoea, hirsutism and lowered pitch. Here, we report on a woman with IRS, postmenopausal virilization and increased testosterone levels d...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-068
更新日期:2005-01-01 00:00:00
abstract::SAPHO syndrome is a group of bone and joint abnormalities associated with skin lesions. A 29-year-old male presented with severe acne on his trunk and anterior chest wall, right knee and foot pain. Radiographs and magnetic resonance images showed hyperostosis in the sternocostoclavicular region, sclerosis of one-third...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-045
更新日期:2006-01-01 00:00:00
abstract::Two female patients, 63 and 78 years of age, underwent femoropopliteal bypass with polytetrafluoroethylene (PTFE) graft and distal vein cuff. They developed graft occlusion due to false aneurysm at the site of vein cuff during one and eight weeks after surgery, respectively. Improper suture technique or weak vein wall...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-178
更新日期:2000-01-01 00:00:00
abstract:INTRODUCTION:Research about pregnancy-planning behaviour mostly focuses on women, even though pregnancy planning usually also concerns men. The purpose of this study was to investigate how men plan for family, and to measure their fertility knowledge after having become fathers. MATERIAL AND METHODS:Data were collecte...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.1080/03009734.2017.1316531
更新日期:2017-06-01 00:00:00
abstract:AIM:The aim of this study was to describe content and procedures in some selected Swedish health care quality registries (QRs) of relevance to regulatory decision-making. METHODS:A workshop was organized with participation of seven Swedish QRs which subsequently answered a questionnaire regarding registry content on d...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.1080/03009734.2017.1285837
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:The incidence of fentanyl-induced cough (FIC) during induction of general anesthesia varies around 40% and is undesirable. It increases intracranial, intraocular, and intra-abdominal pressures. This prospective, randomized, double-blind, placebo-controlled study evaluated the effect of dexmedetomidine (DEX) ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章,随机对照试验
doi:10.3109/03009734.2011.629749
更新日期:2012-03-01 00:00:00
abstract::Secondary amyloidosis (AA amyloidosis) is a well known cause of nephrotic syndrome and renal failure. Several studies in patients with nephrotic syndrome have suggested a beneficial effect of angiotensin-converting enzyme inhibitors (ACEI). Angiotensin II (ATII) receptor antagonists effect on the long term is not know...
journal_title:Upsala journal of medical sciences
pub_type: 临床试验,杂志文章
doi:10.3109/2000-1967-142
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Somatostatin acts through five receptor subtypes (SSTRs 1-5). We aimed to investigate SSTRs mRNA expression and protein distribution in whole rat embryos, with special emphasis on the pancreas. MATERIAL AND METHODS:Rat embryos were collected on embryonal days 10, 11, 12, 14, 15, 17, 19, 21, and at birth. Pr...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2015.1035413
更新日期:2015-01-01 00:00:00
abstract::The purpose of this study is to verify that compound muscle action potentials (CMAPs) generated a stationary potential and to examine extension of the CMAPs away from the stimulated muscle. A referential derivation and/or bipolar derivation to record the stationary potentials were carried out following tibial nerve st...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-103
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:Women previously giving birth with cesarean section have an increased risk of postpartum hemorrhage (PPH) and retained placenta. The objective of this study was to determine if anterior placental location increased the risk of PPH and retained placenta in such women. MATERIALS AND METHODS:We performed a pros...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.1080/03009734.2017.1356405
更新日期:2017-08-01 00:00:00
abstract::The tubuloglomerular feedback mechanism is highly activated in juxtamedullary nephrons and considered to play a major role in intrarenal regulation of glomerular filtration rate. The vasculature of juxtamedullary nephrons is highly vasoreactive with a high ability for vasodilation. This vasoreactivity is a prerequisit...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009739209179287
更新日期:1992-01-01 00:00:00
abstract::The effect of a peroral dose of olsalazine sodium on the migrating motor complexes (MMC) in the upper small bowel was studied by manometry in nine healthy volunteers during fasting. Recordings were obtained from the duodenum and/or the upper jejunum for 4.0 - 7.5 h. During total baseline observation periods of 30 h, f...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738709178694
更新日期:1987-01-01 00:00:00
abstract::For the corticotropin-releasing-hormone stimulation test the number of samplings and measurements are reduced to two--and the ratio between concentrations at 60 min and 0 min is calculated. The difference between the information given by absolute concentrations and ratio is negligible, but by using ratio, the influenc...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009739309179325
更新日期:1993-01-01 00:00:00
abstract::Prototype instruments are developed for determining haemoglobin and glucose content of blood based on optothermal spectroscopy. The optothermal instrument is described. The results of clinical haemoglobin and glucose tests show good agreement with standard methods. For haemoglobin a method reproducibility of better th...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738609178508
更新日期:1986-01-01 00:00:00
abstract::Routine methods are proposed for the analysis of haemorheologic variables with only one instrument, a Low Shear 30 rotational couette viscometer. The variables are plasma viscosity, whole blood apparent viscosity, erythrocyte aggregation tendency and erythrocyte fluidity. These variables, in addition to erythrocyte vo...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738909179250
更新日期:1989-01-01 00:00:00
abstract::Determinations were made of the 2-hour 22Na space and the 1 and 2 hour 51Cr EDTA spaces in a number of tissues. In regions where the two 51Cr-EDTA spaces were similar and smaller than or similar to the 22Na space the former spaces were regarded as measures of the extra-cellular volume. Using previously published data ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009737909179148
更新日期:1979-01-01 00:00:00
abstract::The occurrence of bacteriuria in spinal cord injured patients with neurogenic bladder dysfunction who used clean intermittent catheterisation to empty their bladders was studied in order to examine cut-off concentration breakpoints for significant bacteriuria in this group of patients using procedures of the European ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-107
更新日期:2004-01-01 00:00:00
abstract::One hundred and fifty women with a diagnosis of toxaemia of pregnancy treated in the Department of Obstetrics and Gynaecology, University Hospital, Uppsala between 1964 and 1968 were investigated. One hundred women were still living in the area in 1975 and thus could be restudied. The participation rate was 100% in th...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009737809179119
更新日期:1978-01-01 00:00:00
abstract::Early discharge, defined as hospital leave 24-48 hours after birth, was introduced at Falun Hospital in 1984. 164 women interested in participating in an evaluative study of the program were randomly allocated in late pregnancy to an Experimental group (EG) offered early discharge, and a Control group (CG) offered the...
journal_title:Upsala journal of medical sciences
pub_type: 临床试验,杂志文章,随机对照试验,评审
doi:10.3109/03009738709178701
更新日期:1987-01-01 00:00:00
abstract:AIM:To gain a deeper understanding of first-time parents' experiences of early discharge from hospital after delivery and home-based postnatal care. MATERIAL AND METHODS:The study was comprised of focus group interviews, interviews with couples and with fathers. Twenty-one parents participated. INCLUSION CRITERIA:hea...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009730903431809
更新日期:2010-05-01 00:00:00
abstract::Antimicrobial susceptibility testing with phenotypic methods requires breakpoints, i.e. a minimum inhibitory concentration (MIC) categorizing micro-organisms into susceptible, intermediately susceptible, and resistant for the relevant antimicrobial agent. Determinations of breakpoints require tools such as the underst...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章,评审
doi:10.3109/03009734.2014.901446
更新日期:2014-05-01 00:00:00
abstract::There has been only one reported case of neuromuscular scoliosis following chronic inflammatory demyelinating polyneuropathy (CIDP). However, no cases of scoliosis that were treated with surgery secondary to CIDP have been previously described. A 16-year-old boy with CIDP was consultant due to the progression of scoli...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2012.757682
更新日期:2013-05-01 00:00:00
abstract::Factors that may influence the water transport through the skin in infants on their first day of life were studied with a method based on determination of the vapour pressure gradient in the air layer close to the skin surface. The evaporation rate from the skin was found to vary with the site of measurement, ambient ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738109179207
更新日期:1981-01-01 00:00:00
abstract::Ventilation with decelerating inspiratory flow is known to reduce the dead space fraction and to decrease PaCO2. Constant inspiratory flow with an end-inspiratory pause (EIP) is also known to increase the removal of CO2. The aim of the study was to elucidate the effect of the pause/no-flow period while both the patter...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.1517/03009734000000044
更新日期:2000-01-01 00:00:00
abstract::The bisphosphonates are potent inhibitors of osteoclastic bone resorption that mainly have been used for treatment of hypercalcaemia secondary to malignancy. We have performed a controlled dose-finding study of oral pamidronate that was given to 60 patients with a history of fracture of the distal forearm, an enhanced...
journal_title:Upsala journal of medical sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/03009739109179272
更新日期:1991-01-01 00:00:00
abstract:AIM:The purpose was to assess the direct costs of screening for high blood pressure and blood glucose in dental care and of follow-up in primary health care and, based on these data, arrive at a prediction function. Study population. All subjects coming for routine check-ups at three dental health clinics were invited ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章,多中心研究
doi:10.3109/03009734.2013.818599
更新日期:2013-11-01 00:00:00