Short-term effects of pamidronate on biochemical markers of bone metabolism in osteoporosis--a placebo-controlled dose-finding study.

Abstract:

:The bisphosphonates are potent inhibitors of osteoclastic bone resorption that mainly have been used for treatment of hypercalcaemia secondary to malignancy. We have performed a controlled dose-finding study of oral pamidronate that was given to 60 patients with a history of fracture of the distal forearm, an enhanced bone turnover and a lowered bone mineral density. Different doses of pamidronate, 75 mg and 150 mg daily, or placebo were given to parallel groups. Fasting specimens of blood and urine were collected before the treatment period and at regular intervals. Oral pamidronate caused a dose-related reduction on the biochemical markers of bone resorption, i.e. fasting urinary calcium, hydroxyproline, pyridinoline and deoxypyridinoline that was seen already after the first week. The inhibition was evident during the treatment period and 4 weeks thereafter but not 12 weeks after cessation of therapy. Also the levels of serum osteocalcin, a marker of bone formation, were lowered during treatment with the higher dose.

journal_name

Ups J Med Sci

authors

Mallmin H,Ljunghall S,Larsson K,Lindh E

doi

10.3109/03009739109179272

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

205-12

issue

3

eissn

0300-9734

issn

2000-1967

journal_volume

96

pub_type

临床试验,杂志文章,随机对照试验
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    abstract::Determinations were made of the 2-hour 22Na space and the 1 and 2 hour 51Cr EDTA spaces in a number of tissues. In regions where the two 51Cr-EDTA spaces were similar and smaller than or similar to the 22Na space the former spaces were regarded as measures of the extra-cellular volume. Using previously published data ...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009737909179148

    authors: Bill A

    更新日期:1979-01-01 00:00:00

  • Acute effects of a new stimulatory luteinizing hormone-releasing hormone analogue D-Ser(TBU)(6)-EA(10)-LRH on the gonadotrophin and gonadal steroid secretion in women with amenorrhoea.

    abstract::A new stimulatory luteinizing hormone-releasing hormone (LRH) analogue D-Ser(TBU)(6)-EA(10)-LRH was administered subcutaneously in a dose of 10 microg into 10 women with amenorrhoea. The injection resulted in a 20-fold increase of the LH level in blood and a 5-fold increase of the FSH level with maxima at 4 and 6 h af...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009737709179054

    authors: Nillius SJ,Wide L

    更新日期:1977-01-01 00:00:00

  • Bacteriuria in spinal cord injured patients with neurogenic bladder dysfunction.

    abstract::The occurrence of bacteriuria in spinal cord injured patients with neurogenic bladder dysfunction who used clean intermittent catheterisation to empty their bladders was studied in order to examine cut-off concentration breakpoints for significant bacteriuria in this group of patients using procedures of the European ...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/2000-1967-107

    authors: Svensson E,Ertzgaard P,Forsum U

    更新日期:2004-01-01 00:00:00

  • Impact of creatinine production on the agreement between glomerular filtration rate estimates using cystatin C-derived, and 4- and 6-variable Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equ

    abstract:BACKGROUND:It has recently been reported that patient selection has a strong impact on the agreement between glomerular filtration rate (GFR) estimates from serum cystatin C and creatinine. The aim of our study was to evaluate the effect of creatinine production rate (CPR) on this subject. MATERIAL AND METHODS:GFR was...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009734.2012.696154

    authors: Hermida-Cadahia EF,Lampon N,Tutor JC

    更新日期:2012-11-01 00:00:00

  • Tubuglomerular feedback control in long-looped nephrons. Topical minireview.

    abstract::The tubuloglomerular feedback mechanism is highly activated in juxtamedullary nephrons and considered to play a major role in intrarenal regulation of glomerular filtration rate. The vasculature of juxtamedullary nephrons is highly vasoreactive with a high ability for vasodilation. This vasoreactivity is a prerequisit...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009739209179287

    authors: Ulfendahl HR,Göransson-Nyberg A,Hansell P,Sjöquist M

    更新日期:1992-01-01 00:00:00

  • Effect of losartan treatment on the proteinuria in normotensive patients having proteinuria due to secondary amyloidosis.

    abstract::Secondary amyloidosis (AA amyloidosis) is a well known cause of nephrotic syndrome and renal failure. Several studies in patients with nephrotic syndrome have suggested a beneficial effect of angiotensin-converting enzyme inhibitors (ACEI). Angiotensin II (ATII) receptor antagonists effect on the long term is not know...

    journal_title:Upsala journal of medical sciences

    pub_type: 临床试验,杂志文章

    doi:10.3109/2000-1967-142

    authors: Odabas AR,Cetinkaya R,Selcuk Y,Bilen H

    更新日期:2001-01-01 00:00:00

  • Hepatic triglyceride and lipoprotein lipase activities of post-heparin plasma in normals and hypertriglyceridemics.

    abstract::Post-heparin plasma hepatic triglyceride lipase (H-TGL) and lipoprotein lipase (LPL) activities were 8-34 and 3.5-21 (range) mu mol/ml/hr respectively in males with normal serum lipid concentrations. In females the corresponding values were 4-25 and 4-16 mu mol/ml/hr. No significant differences were observed between a...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009737909179158

    authors: Boberg J,Boberg M,Gross R,Turner JD,Augustin J,Brown WV

    更新日期:1979-01-01 00:00:00

  • Association between perioperative blood transfusion and early postoperative cognitive dysfunction in aged patients following total hip replacement surgery.

    abstract:INTRODUCTION:Accumulating evidence suggests that enhanced inflammatory responses contribute to the pathogenesis of postoperative cognitive dysfunction (POCD). Blood transfusion can trigger an enhancement of acute inflammatory responses. Therefore, we hypothesized that perioperative blood transfusion is associated with ...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009734.2013.873502

    authors: Zhu SH,Ji MH,Gao DP,Li WY,Yang JJ

    更新日期:2014-08-01 00:00:00

  • Glucose control of glucagon secretion-'There's a brand-new gimmick every year'.

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    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章,评审

    doi:10.3109/03009734.2016.1154905

    authors: Gylfe E

    更新日期:2016-05-01 00:00:00

  • Time-trend of melanoma screening practice by primary care physicians: a meta-regression analysis.

    abstract:OBJECTIVE:To assess whether the proportion of primary care physicians implementing full body skin examination (FBSE) to screen for melanoma changed over time. METHODS:Meta-regression analyses of available data. DATA SOURCES:MEDLINE, ISI, Cochrane Central Register of Controlled Trials. RESULTS:Fifteen studies surveyi...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章,meta分析

    doi:10.1080/03009730802579620

    authors: Valachis A,Mauri D,Karampoiki V,Polyzos NP,Cortinovis I,Koukourakis G,Zacharias G,Xilomenos A,Tsappi M,Casazza G

    更新日期:2009-01-01 00:00:00

  • Tumor-promoting functions of transforming growth factor-β in progression of cancer.

    abstract::Transforming growth factor-β (TGF-β) elicits both tumor-suppressive and tumor-promoting functions during cancer progression. Here, we describe the tumor-promoting functions of TGF-β and how these functions play a role in cancer progression. Normal epithelial cells undergo epithelial-mesenchymal transition (EMT) throug...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章,评审

    doi:10.3109/03009734.2011.638729

    authors: Miyazono K,Ehata S,Koinuma D

    更新日期:2012-05-01 00:00:00

  • High-resolution arteriography of the major peripheral vessels.

    abstract::In experimental studies using a 0.1 mm focal sport tube, rare-eath screens, Cornex 4 film and diluted contrast agent (120 mgI/ml), 6Xmagnification detail in the walls of major arteries that could not be identified with standard radiography or 3Xmagnification. The method is applicable to studies of arteriosclerotic cha...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009737509179004

    authors: Björk L,Sandor T

    更新日期:1975-01-01 00:00:00

  • How individuals with the irritable bowel syndrome describe their own symptoms before formal diagnosis.

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    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009734.2015.1040529

    authors: Molinder H,Agréus L,Kjellström L,Walter S,Talley NJ,Andreasson A,Nyhlin H

    更新日期:2015-01-01 00:00:00

  • Rationale for a Swedish cohort consortium.

    abstract::We herein outline the rationale for a Swedish cohort consortium, aiming to facilitate greater use of Swedish cohorts for world-class research. Coordination of all Swedish prospective population-based cohorts in a common infrastructure would enable more precise research findings and facilitate research on rare exposure...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.1080/03009734.2018.1556754

    authors: Sundström J,Björkelund C,Giedraitis V,Hansson PO,Högman M,Janson C,Koupil I,Kristenson M,Trolle Lagerros Y,Leppert J,Lind L,Lissner L,Johansson I,Ludvigsson JF,Nilsson PM,Olsson H,Pedersen NL,Rosenblad A,Rosengren A,

    更新日期:2019-01-01 00:00:00

  • Effect of in vitro stability of dietary fish oil on lipid peroxidation and prostanoids in vivo.

    abstract::Dietary supplementation of rats with fish oil for 18 days resulted in signs of lipid peroxidation, with increased malondialdehyde production in plasma and myocardium. This increase in malondialdehyde could be completely prevented by supplementing the fish oil with a new natural antioxidant mixture (Pufanox) which is k...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009739809178950

    authors: Jokela R,Engström K,Wallin R,Saldeen T

    更新日期:1998-01-01 00:00:00

  • Coagulation and fibrinolysis during the normal menstrual cycle.

    abstract::Thirteen healthy women (age 24-44 yrs) were studied during their menstrual cycle. Samples were taken 2-3 times weekly for six consecutive weeks. Plasma concentrations of oestradiol and progesterone were determined in each blood sample and only women found to be ovulatory were included. From the hormone data the cycles...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009738909178559

    authors: Siegbahn A,Odlind V,Hedner U,Venge P

    更新日期:1989-01-01 00:00:00

  • Quality of life and functional outcomes 10 years after laparoscopic radical prostatectomy.

    abstract:BACKGROUND:Minimally invasive laparoscopic radical prostatectomy (LRP) has proven equally effective as open surgery in terms of cancer control and peroperative complication rate with less bleeding and postoperative pain. However, long-term follow-up data after LRP are scarce, especially as related to quality of life (Q...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009734.2013.868560

    authors: Wang EY,Eriksson HG

    更新日期:2014-03-01 00:00:00

  • Standard computer programs in statistical analysis of survival in childhood lymphoblastic leukemia.

    abstract::A material comprising all children in Sweden with acute lymphoblastic leukemia diagnosed in the years 1973-80 was analysed statistically. The total number of children was 505. Studies were made of 38 different variables, using frequency tables, cross tables, life table studies (1) and linear regression analysis accord...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009738209178424

    authors: Andersson BW,Gustafsson G

    更新日期:1982-01-01 00:00:00

  • Dermatoglyphics in individuals with asocial behaviour.

    abstract::The patterns of fingertip prints (dermatoglyphics) in Swedish series of sexual offenders of law compared with common offenders of law and normal individuals were analysed. The dermatoglyphic patterns in common offenders of law did not differ from those in normal individuals. The group of sexual offenders of law showed...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009739409179351

    authors: Gustavson KH,Modrzewska K,Sjöquist KE

    更新日期:1994-01-01 00:00:00

  • Chondroitin sulfate proteoglycan 2 (CSPG2) gene polymorphisms rs173686 and rs251124 are not associated with intracranial aneurysms in Chinese Han nationality.

    abstract:BACKGROUND:There is evidence suggesting that genetic variants in the chondroitin sulfate proteoglycan2 (CSPG2, also known as versican) gene are involved in the pathogenesis of intracranial aneurysms (IAs). Some authors have demonstrated that single nucleotide polymorphisms (SNPs) rs173686 and rs251124 in the promoter r...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/2000-1967-201

    authors: Sun H,Zhang D,Zhao J

    更新日期:2007-01-01 00:00:00

  • Catechol-O-methyltransferase activity in human erythrocytes: methodological aspects.

    abstract::Different methodological aspects on the assay of human erythrocyte catechol-O-methyltransferase (COMT) activity were studied. No temporal variations were found either over a 24 hour period or over one month. Erythrocytes from whole blood collected with any of the anticoagulants heparin, EDTA or citrate could be used a...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009738109179242

    authors: Floderus Y,Sääf J,Ross SB,Wetterberg L

    更新日期:1981-01-01 00:00:00

  • Grade of aortic atherosclerosis: a valuable adjunct to coronary flow velocity reserve in the evaluation of coronary artery disease.

    abstract:BACKGROUND:Atherosclerosis is a generalized disease of the arterial vasculature; among thus it manifests in the descending aorta and the coronary arteries. We tested whether known risk factors, the coronary flow velocity reserve and the grade of aortic atherosclerosis detected by transoesophageal echocardiography in th...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/2000-1967-097

    authors: Nemes A,Thury A,Forster T,Boda K,Csanády M

    更新日期:2007-01-01 00:00:00

  • Surgical treatment and intraoperative spinal cord monitoring in scoliosis associated with chronic inflammatory demyelinating polyneuropathy: a case report.

    abstract::There has been only one reported case of neuromuscular scoliosis following chronic inflammatory demyelinating polyneuropathy (CIDP). However, no cases of scoliosis that were treated with surgery secondary to CIDP have been previously described. A 16-year-old boy with CIDP was consultant due to the progression of scoli...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009734.2012.757682

    authors: Kudo D,Miyakoshi N,Hongo M,Kasukawa Y,Ishikawa Y,Misawa A,Shimada Y

    更新日期:2013-05-01 00:00:00

  • Kinetic measurement of the erythrocyte sedimentation rate.

    abstract::A method for estimation of the erythrocyte sedimentation from repeated measurements during the initial part of the sedimentation phase is described. Based on the measurements between 18 and 24 minutes after the beginning of the reaction, the sedimentation at 60 minutes is estimated. The estimate is highly correlated t...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009739409179362

    authors: Kallner A,Engervall P,Björkholm M

    更新日期:1994-01-01 00:00:00

  • Determination of sialic acid residues in transferrin by oxidative-reductive immunoassay.

    abstract::A method is described for the determination of sialic acid residues in glycoproteins displaying microheterogeneity in the sugar residue. The new method is based on combining an oxidative-reductive step with binding of the glycoprotein to an immunoadsorbent. After a mild oxidation with sodium metaperiodate the sugar is...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009738609178487

    authors: Cervén E,Ronquist G

    更新日期:1986-01-01 00:00:00

  • Dexmedetomidine reduces the incidence of fentanyl-induced cough: a double-blind, randomized, and placebo-controlled study.

    abstract:OBJECTIVES:The incidence of fentanyl-induced cough (FIC) during induction of general anesthesia varies around 40% and is undesirable. It increases intracranial, intraocular, and intra-abdominal pressures. This prospective, randomized, double-blind, placebo-controlled study evaluated the effect of dexmedetomidine (DEX) ...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/03009734.2011.629749

    authors: He L,Xu JM,Dai RP

    更新日期:2012-03-01 00:00:00

  • Clusterin as a potential marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy.

    abstract::Introduction: Carotid endarterectomy (CEA) is a surgical procedure used in the prevention of ischemic stroke. However, this procedure can cause complications of ischemia-reperfusion injury to the brain. Clusterin (CLU) is a cytoprotective chaperone protein that is released from neurons in response to various neurologi...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.1080/03009734.2019.1646359

    authors: Iłżecka J,Iłżecki M,Grabarska A,Dave S,Feldo M,Zubilewicz T

    更新日期:2019-08-01 00:00:00

  • Can costs of screening for hypertension and diabetes in dental care and follow-up in primary health care be predicted?

    abstract:AIM:The purpose was to assess the direct costs of screening for high blood pressure and blood glucose in dental care and of follow-up in primary health care and, based on these data, arrive at a prediction function. Study population. All subjects coming for routine check-ups at three dental health clinics were invited ...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章,多中心研究

    doi:10.3109/03009734.2013.818599

    authors: Engström S,Borgquist L,Berne C,Gahnberg L,Svärdsudd K

    更新日期:2013-11-01 00:00:00

  • Tumor response evaluation criteria for HCC (hepatocellular carcinoma) treated using TACE (transcatheter arterial chemoembolization): RECIST (response evaluation criteria in solid tumors) version 1.1 and mRECIST (modified RECIST): JIVROSG-0602.

    abstract:BACKGROUND:Two standard sets of criteria are used to evaluate the tumor response of hepatocellular carcinoma (HCC): RECIST (Response Evaluation Criteria in Solid Tumors) and modified RECIST (mRECIST). The purpose was to compare two tumor response evaluation criteria, RECIST version 1.1 and mRECIST, for HCC treated usin...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章,多中心研究

    doi:10.3109/03009734.2012.729104

    authors: Sato Y,Watanabe H,Sone M,Onaya H,Sakamoto N,Osuga K,Takahashi M,Arai Y,Japan Interventional Radiology in Oncology Study Group-JIVROSG.

    更新日期:2013-03-01 00:00:00

  • Biological description of the cortisol responses to corticotropin-releasing-hormone (CRH) stimulation. An optimization and simplification of the test.

    abstract::For the corticotropin-releasing-hormone stimulation test the number of samplings and measurements are reduced to two--and the ratio between concentrations at 60 min and 0 min is calculated. The difference between the information given by absolute concentrations and ratio is negligible, but by using ratio, the influenc...

    journal_title:Upsala journal of medical sciences

    pub_type: 杂志文章

    doi:10.3109/03009739309179325

    authors: Grodum E,Petersen PH,Hangaard J,Hansen TB,Hagen C

    更新日期:1993-01-01 00:00:00