当前位置： SCI文献检索 > UPSALA JOURNAL OF MEDICAL SCIENCES期刊下所有文献 > TCI : Target controlled infusion, or totally confused infusion? Call for an optimised population based pharmacokinetic model for propofol.

TCI : Target controlled infusion, or totally confused infusion? Call for an optimised population based pharmacokinetic model for propofol.

Abstract：

:Different pharmacokinetic models for target controlled infusion (TCI) of propofol are available in the recently launched open TCI systems. There is also a compelling choice to work with either plasma- or effect-site targets. Knowledge about the clinical consequences of different alternatives is of importance. We aimed to illustrate the potential differences in the actual drug delivery/output between three present commercially available and clinically used pharmacokinetic models: the original Marsh model, which is also implemented in the Diprifusor, the "modified Marsh-" and the Schnider models. Simulations were made in the TivaTrainer program (eurosiva.com). Firstly, our standard plasma target regimen was simulated, and secondly an effect-site target of 3.5 microg/mL was chosen. Thirdly, real infusors were used for measuring the time to reach defined predicted effect-site concentrations when aiming at a plasma target of 6 microg/mL. Identical patient characteristics were used in all simulations: male, 170 cm, 70 kg, 40 years of age. Resulting predicted effect-site peak concentrations, and used bolus doses were recorded, as were the resulting plasma over-shoot, and time frames. The plasma target regimen gave predicted effect-site peaks in the different models ranging from 3.6 to 7.2 microg/mL, reached after 2(3/4) to 4 minutes. To reach the same effect-site target, the three models used bolus doses ranging from 68 to 150 mg given during 22 to 46 seconds. The predicted plasma concentration over-shoots varied from 5.0 to 13.4 microg/mL. There were obvious differences between the models in the time taken to reach defined effect-site concentrations. We observed clinically significant different results between the models. The choice of model will make a difference for the patient. To eliminate confusion - not necessarily to improve precision - we call for an optimised population based pharmacokinetic model for propofol - a consensus model!

journal_name

Ups J Med Sci

journal_title

Upsala journal of medical sciences

authors

Enlund M

doi

10.3109/2000-1967-222

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

161-70

issue

eissn

0300-9734

issn

2000-1967

pii

http://urn.kb.se/resolve?urn=urn:nbn:se:pub:diva-2

journal_volume

113

pub_type

杂志文章

在线工具

TCI : Target controlled infusion, or totally confused infusion? Call for an optimised population based pharmacokinetic model for propofol.