Abstract:
:Secondary osteosarcoma arising after the treatment of hematologic malignancies other than Hodgkin's lymphoma is rare. We report two cases of secondary osteosarcoma arising after treatment for childhood hematologic malignancies (non-Hodgkin's lymphoma and lymphoblastic leukemia). A 10-year-old boy, at the age of 3, was diagnosed with non-Hodgkin's lymphoma. He received chemotherapy, radiation, and bone-marrow transplantation and then was in complete remission. At 6 years, he complained of increasing pain of the right thigh and was diagnosed with osteoblastic osteosarcoma. A 26-year-old man, at the age of 6, was diagnosed as having acute lymphoblastic leukemia (ALL). He received chemotherapy, radiation, and peripheral blood stem cell transplantation (PBSCT). At 11 years after PBSCT, he visited with the complaint of left lumbar swelling. He was diagnosed with chondroblastic osteosarcoma. In both cases alkaline phosphatase (ALP) had already increased prior to the onset of the symptom. We should rule out secondary osteosarcoma at the abnormal elevation of ALP during clinical follow-up of patients after treatment of childhood hematologic malignancies.
journal_name
Ups J Med Scijournal_title
Upsala journal of medical sciencesauthors
Okada A,Hatori M,Hosaka M,Watanuki M,Itoi Edoi
10.3109/03009730903177340subject
Has Abstractpub_date
2009-01-01 00:00:00pages
249-55issue
4eissn
0300-9734issn
2000-1967journal_volume
114pub_type
杂志文章abstract:BACKGROUND:Autologous chondrocyte implantation (ACI) is considered a promising choice for the treatment of cartilage defects. However, the application of ACI to osteoarthritic patients is, in general, contraindicated. The purpose of this study is to evaluate the efficiency of three-dimensionally structured ACI (3D-ACI;...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2011.552812
更新日期:2011-05-01 00:00:00
abstract::Previous experiments have demonstrated that neuronal cells within pancreatic islets survive the isolation procedure and constitute an integral part of transplanted pancreatic islets. The aim of the present study was to investigate to what extent immunosuppressive drugs affects the acute survival of intra-islet neurons...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-167
更新日期:2001-01-01 00:00:00
abstract::Platelet-derived growth factor B (PDGF-B) is a growth factor promoting and regulating cell migration, proliferation, and differentiation, involved in both developmental processes and in maintaining tissue homeostasis under strict regulation. What are the implications of prolonged or uncontrolled growth factor signalin...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2012.654860
更新日期:2012-05-01 00:00:00
abstract::One hundred and fifty women with a diagnosis of toxaemia of pregnancy treated in the Department of Obstetrics and Gynaecology, University Hospital, Uppsala between 1964 and 1968 were investigated. One hundred women were still living in the area in 1975 and thus could be restudied. The participation rate was 100% in th...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009737809179119
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Non-contrast computed tomography (NCT) has become an important diagnostic tool in acute abdominal pain, but the drawback is the increased radiation dose compared to abdominal plain film (APF). PURPOSE:To evaluate whether NCT, including low-dose computed tomography (LDCT, using 50 mAs), provides more diagnos...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009730903294871
更新日期:2010-05-01 00:00:00
abstract::The present investigation on 20 patients after total hip replacement surgery has confirmed that the posttraumatic increase of the fibrinolysis inhibition activity (FIA) in serum and plasminogen-depleted serum is due to the primary fibrinolysis inhibitor (PFI, alpha 2-antiplasmin). This protein exists in at least two f...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738209178409
更新日期:1982-01-01 00:00:00
abstract::The role of the sympathetic nerve system is still unknown in different types of hypertension. The procedure used in the evaluation of suspect renovascular hypertension has been revised in such a way that renal blood flow, renal arterial blood pressure and plasma renin activity in renal vein could be determined prior t...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009737609179031
更新日期:1976-01-01 00:00:00
abstract::There are few reports concerning the gait characteristics of sciatic nerve palsy. Four cases, one with complete palsy and three with incomplete palsy, are presented. Complete palsy (case 1) was due to sacrifice of the sciatic nerve in a wide excision for chondrosarcoma in the left ischium. Incomplete palsy (cases 2, 3...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-116
更新日期:2003-01-01 00:00:00
abstract:AIM:To investigate how individuals fulfilling the Rome II criteria for irritable bowel syndrome (IBS) spontaneously described their symptoms. METHOD:From a general population, 1,244 randomly sampled adults were asked to describe their gastrointestinal symptoms (if any) verbally, in their own words, at a semi-structure...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2015.1040529
更新日期:2015-01-01 00:00:00
abstract::Secondary amyloidosis (AA amyloidosis) is a well known cause of nephrotic syndrome and renal failure. Several studies in patients with nephrotic syndrome have suggested a beneficial effect of angiotensin-converting enzyme inhibitors (ACEI). Angiotensin II (ATII) receptor antagonists effect on the long term is not know...
journal_title:Upsala journal of medical sciences
pub_type: 临床试验,杂志文章
doi:10.3109/2000-1967-142
更新日期:2001-01-01 00:00:00
abstract::Background: Although chronic obstructive pulmonary disease (COPD) is a life-limiting disease with a significant symptom burden, the patients are more often referred to nursing homes (NH), than to specialist palliative care (SPC) at the end of life (EOL). This study aimed to compare patients with COPD in SPC with those...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.1080/03009734.2019.1586803
更新日期:2019-04-01 00:00:00
abstract::SAPHO syndrome is a group of bone and joint abnormalities associated with skin lesions. A 29-year-old male presented with severe acne on his trunk and anterior chest wall, right knee and foot pain. Radiographs and magnetic resonance images showed hyperostosis in the sternocostoclavicular region, sclerosis of one-third...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-045
更新日期:2006-01-01 00:00:00
abstract::Post-heparin plasma hepatic triglyceride lipase (H-TGL) and lipoprotein lipase (LPL) activities were 8-34 and 3.5-21 (range) mu mol/ml/hr respectively in males with normal serum lipid concentrations. In females the corresponding values were 4-25 and 4-16 mu mol/ml/hr. No significant differences were observed between a...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009737909179158
更新日期:1979-01-01 00:00:00
abstract::Oxyhemoglobin, methemoglobin and hematin were found to catalyze xanthine-oxidase-induced peroxidation of phospholipid liposomes, while oxy- and metmyoglobin were inactive in this respect. The peroxidation was inhibited by desferrioxamine and by EDTA. Peroxidation catalyzed by 0.4 microM oxyhemoglobin was decreased by ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738809178547
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Open reduction and internal fixation using an interlocking plate system has gained popularity for the treatment of dorsally displaced distal radius fractures. PURPOSE:To evaluate the functional and radiological results of treating unstable distal radius fractures with the volar locking plate. PATIENTS AND ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2011.594183
更新日期:2011-11-01 00:00:00
abstract:AIM:To gain a deeper understanding of first-time parents' experiences of early discharge from hospital after delivery and home-based postnatal care. MATERIAL AND METHODS:The study was comprised of focus group interviews, interviews with couples and with fathers. Twenty-one parents participated. INCLUSION CRITERIA:hea...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009730903431809
更新日期:2010-05-01 00:00:00
abstract::Prototype instruments are developed for determining haemoglobin and glucose content of blood based on optothermal spectroscopy. The optothermal instrument is described. The results of clinical haemoglobin and glucose tests show good agreement with standard methods. For haemoglobin a method reproducibility of better th...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738609178508
更新日期:1986-01-01 00:00:00
abstract::The acute phase reaction is an unspecific response to inflammatory stimuli characterized by alterations in the concentration of several plasma proteins. It is of great clinical value to monitor the inflammatory state in patients with rheumatoid arthritis. The erythrocyte sedimentation rate (ESR) and C-reactive protein...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009739809178943
更新日期:1998-01-01 00:00:00
abstract::Diabetes in the mother may cause disturbances in the chondrocyte development in the embryo. A rat model was used to investigate whether this was reflected in the production of proteoglycans by cells from two embryonic regions. One of these regions is resistant (limb bud) and the other susceptible (mandibular arch) to ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009739009178574
更新日期:1990-01-01 00:00:00
abstract::By means of an accurate immunoenzymatic assay, the prevalence was studied of antibodies to hepatitis C virus (HCV) in three different populations: 74 patients affected with hepatocellular carcinoma (HCC) on preexisting cirrhosis, 82 patients with liver cirrhosis but with no apparent neoplasm, and 70 control subjects, ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009739209179300
更新日期:1992-01-01 00:00:00
abstract::For staging of Hodgkin's disease 45 patients underwent lymphography and abdominal computed tomography (CT); in 31 of them ultrasound examination was also performed. In cases of retroperitoneal lymph node enlargement lymphography and CT are diagnostically equivalent, whereas the poorer resolution of ultrasound reduces ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738409179500
更新日期:1984-01-01 00:00:00
abstract::In 2 monkeys of the species Macaca fascicularis the three dorsal column nuclei and the lateral cervical nucleus have been investigated immunocytochemically with antiserum against Substance P. The Substance P labeling was widely spread but rather sparse. It occurred in small structures of the size of boutons in the gra...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738909178557
更新日期:1989-01-01 00:00:00
abstract::Determinations were made of the 2-hour 22Na space and the 1 and 2 hour 51Cr EDTA spaces in a number of tissues. In regions where the two 51Cr-EDTA spaces were similar and smaller than or similar to the 22Na space the former spaces were regarded as measures of the extra-cellular volume. Using previously published data ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009737909179148
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:There is evidence suggesting that genetic variants in the chondroitin sulfate proteoglycan2 (CSPG2, also known as versican) gene are involved in the pathogenesis of intracranial aneurysms (IAs). Some authors have demonstrated that single nucleotide polymorphisms (SNPs) rs173686 and rs251124 in the promoter r...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/2000-1967-201
更新日期:2007-01-01 00:00:00
abstract::For the corticotropin-releasing-hormone stimulation test the number of samplings and measurements are reduced to two--and the ratio between concentrations at 60 min and 0 min is calculated. The difference between the information given by absolute concentrations and ratio is negligible, but by using ratio, the influenc...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009739309179325
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:Women previously giving birth with cesarean section have an increased risk of postpartum hemorrhage (PPH) and retained placenta. The objective of this study was to determine if anterior placental location increased the risk of PPH and retained placenta in such women. MATERIALS AND METHODS:We performed a pros...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.1080/03009734.2017.1356405
更新日期:2017-08-01 00:00:00
abstract:AIM:The purpose was to assess the direct costs of screening for high blood pressure and blood glucose in dental care and of follow-up in primary health care and, based on these data, arrive at a prediction function. Study population. All subjects coming for routine check-ups at three dental health clinics were invited ...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章,多中心研究
doi:10.3109/03009734.2013.818599
更新日期:2013-11-01 00:00:00
abstract::Acid phosphatase in serum was measured in 116 patients with prostatic disease, benign in 59 and malignant in 57 cases. Comparisons were made between radioimmunoassay (RIA) and an enzymatic method. The correlation coefficient between the respective values was 0.96 in patients with untreated prostatic cancer, indicating...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009738309178446
更新日期:1983-01-01 00:00:00
abstract::There has been only one reported case of neuromuscular scoliosis following chronic inflammatory demyelinating polyneuropathy (CIDP). However, no cases of scoliosis that were treated with surgery secondary to CIDP have been previously described. A 16-year-old boy with CIDP was consultant due to the progression of scoli...
journal_title:Upsala journal of medical sciences
pub_type: 杂志文章
doi:10.3109/03009734.2012.757682
更新日期:2013-05-01 00:00:00
abstract::The bisphosphonates are potent inhibitors of osteoclastic bone resorption that mainly have been used for treatment of hypercalcaemia secondary to malignancy. We have performed a controlled dose-finding study of oral pamidronate that was given to 60 patients with a history of fracture of the distal forearm, an enhanced...
journal_title:Upsala journal of medical sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/03009739109179272
更新日期:1991-01-01 00:00:00