Aspirin resistance in patients with type II diabetes mellitus.

Abstract:

BACKGROUND:Diabetic patients exhibit platelet hyperreactivity, which renders them resistant to antithrombotic treatments. We aimed to investigate the prevalence and predictors of aspirin resistance in diabetic patients. MATERIAL AND METHODS:A total of 93 diabetic and 37 non-diabetic participants were included into the study. Aspirin resistance was measured with a whole-blood desktop platelet function analyzer (PFA-100) with an epinephrine agonist. RESULTS:Altogether 41.9% patients with DM were aspirin non-responders. Aspirin resistance was observed in 43.2% of non-diabetic patients (p = 0.89). Presence of diabetes mellitus had no effect on aspirin response (RR 0.95 (95% CI 0.44-2.05), p = 0.89) in the whole study population. Hypercholesterolemia was the only predictor of aspirin resistance in multivariate analysis in diabetic patients (RR 3.09 (95% CI 1.17-8.16), p = 0.023). CONCLUSION:The prevalence of aspirin resistance is comparable in diabetic and non-diabetic patients. Hypercholesterolemia is the only independent predictor of aspirin resistance in diabetic patients.

journal_name

Ups J Med Sci

authors

Tasdemir E,Toptas T,Demir C,Esen R,Atmaca M

doi

10.3109/03009734.2013.861549

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

25-31

issue

1

eissn

0300-9734

issn

2000-1967

journal_volume

119

pub_type

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