Abstract:
:A comparative study has been performed on the effects of high-dose-rate (DR) X-ray beams produced by a plasma focus device (PFMA-3), to exploit its potential medical applications (e.g. radiotherapy), and low-DR X-ray beams produced by a conventional source (XRT). Experiments have been performed at 0.5 and 2 Gy doses on a human glioblastoma cell line (T98G). Cell proliferation rate and potassium outward currents (IK) have been investigated by time lapse imaging and patch clamp recordings. The results showed that PFMA-3 irradiation has a greater capability to reduce the proliferation rate activity with respect to XRT, while it does not affect IK of T98G cells at any of the dose levels tested. XRT irradiation significantly reduces the mean IK amplitude of T98G cells only at 0.5 Gy. This work confirms that the DR, and therefore the source of radiation, is crucial for the planning and optimisation of radiotherapy applications.
journal_name
Radiat Prot Dosimetryjournal_title
Radiation protection dosimetryauthors
Virelli A,Zironi I,Pasi F,Ceccolini E,Nano R,Facoetti A,Gavoçi E,Fiore MR,Rocchi F,Mostacci D,Cucchi G,Castellani G,Sumini M,Orecchia Rdoi
10.1093/rpd/ncv163subject
Has Abstractpub_date
2015-09-01 00:00:00pages
383-7issue
1-4eissn
0144-8420issn
1742-3406pii
ncv163journal_volume
166pub_type
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