Biophysical analysis of radiation induced initial DNA fragmentation.

Abstract:

:Production of double strand breaks (DSBs) and double-stranded DNA fragments after irradiation with high energy nitrogen ions was simulated with stochastic track generation and a high-order chromatin structure (HOCS) model representing a segment of interphase chromosome. The non-random distribution of DNA fragments is predicted for irradiation of HOCS. Agreement with the experimental data is obtained. The influence of HOCS and the role of the background component in DNA fragment distributions are discussed.

journal_name

Radiat Prot Dosimetry

authors

Khvostunov IK,Andreev SG,Eidelman Y

doi

10.1093/oxfordjournals.rpd.a006748

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

151-2

issue

1-4

eissn

0144-8420

issn

1742-3406

journal_volume

99

pub_type

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