Discovery of the earliest-known tetrapod stapes.

abstract：:Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-methylcytosine to 5-hydroxymethylcytosine and regulate gene transcription. However, the molecular mechanism by which TET family enzymes regulate gene transcription remains elusive. Using protein affinity purification, here we search for f...

journal_title：Nature

authors： Chen Q,Chen Y,Bian C,Fujiki R,Yu X

更新日期：2013-01-24 00:00:00

abstract：:The direct involvement of the pituitary-adrenal axis in birth has been well established, at least in sheep, and its removal prolongs pregnancy. As part of the process the fetal sheep adrenal grows rapidly during the 10-15 d prepartum and is associated with a large rise in the plasma corticosteroid concentration. This ...

journal_title：Nature

authors： Roebuck MM,Jones CT,Holland D,Silman R

更新日期：1980-04-17 00:00:00

abstract：:When present in single-stranded DNA, palindromic or quasi-palindromic sequences have the potential to form complex secondary structures, including hairpins, which may facilitate interstrand misalignment of direct repeats and be responsible for diverse types of replication-based mutations, including deletions, addition...

journal_title：Nature

authors： Trinh TQ,Sinden RR

更新日期：1991-08-08 00:00:00

abstract：:The Indian Ocean dipole is a prominent mode of coupled ocean-atmosphere variability, affecting the lives of millions of people in Indian Ocean rim countries. In its positive phase, sea surface temperatures are lower than normal off the Sumatra-Java coast, but higher in the western tropical Indian Ocean. During the ext...

journal_title：Nature

authors： Cai W,Santoso A,Wang G,Weller E,Wu L,Ashok K,Masumoto Y,Yamagata T

更新日期：2014-06-12 00:00:00

abstract：:Scanning probe microscopy is a versatile and powerful method that uses sharp tips to image, measure and manipulate matter at surfaces with atomic resolution. At cryogenic temperatures, scanning probe microscopy can even provide electron tunnelling spectra that serve as fingerprints of the vibrational properties of ads...

journal_title：Nature

authors： Sugimoto Y,Pou P,Abe M,Jelinek P,Pérez R,Morita S,Custance O

更新日期：2007-03-01 00:00:00

abstract：:The murine cardioviruses, such as the Mengo and encephalomyocarditis viruses, and the bovine aphthoviruses, such as foot-and-mouth disease virus, are distinguished among positive-strand RNA viruses by the presence of long homopolymeric poly(C) tracts within their 5' noncoding sequences. Although the specific lengths (...

journal_title：Nature

authors： Duke GM,Osorio JE,Palmenberg AC

更新日期：1990-02-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Díaz RF

更新日期：2018-11-01 00:00:00

abstract：:Transmission of obligate bacterial symbionts between generations is vital for the survival of the host. Although the larvae of certain hydrothermal vent tubeworms (Vestimentifera, Siboglinidae) are symbiont-free and possess a transient digestive system, these structures are lost during development, resulting in adult ...

journal_title：Nature

authors： Nussbaumer AD,Fisher CR,Bright M

更新日期：2006-05-18 00:00:00

abstract：:Environmental change is rapidly accelerating, and many species will need to adapt to survive1. Ensuring that protected areas cover populations across a broad range of environmental conditions could safeguard the processes that lead to such adaptations1-3. However, international conservation policies have largely negle...

journal_title：Nature

authors： Hanson JO,Rhodes JR,Butchart SHM,Buchanan GM,Rondinini C,Ficetola GF,Fuller RA

更新日期：2020-04-01 00:00:00

abstract：:Established infections with the human and simian immunodeficiency viruses (HIV and SIV, respectively) are thought to be permanent with even the most effective immune responses and antiretroviral therapies only able to control, but not clear, these infections. Whether the residual virus that maintains these infections ...

journal_title：Nature

authors： Hansen SG,Piatak M Jr,Ventura AB,Hughes CM,Gilbride RM,Ford JC,Oswald K,Shoemaker R,Li Y,Lewis MS,Gilliam AN,Xu G,Whizin N,Burwitz BJ,Planer SL,Turner JM,Legasse AW,Axthelm MK,Nelson JA,Früh K,Sacha JB,Estes JD

更新日期：2013-10-03 00:00:00

abstract：:The Earth's mantle is isotopically heterogeneous on length scales ranging from centimetres to more than 10(4) kilometres. This heterogeneity originates from partial melt extraction and plate tectonic recycling, whereas stirring during mantle convection tends to reduce it. Here we show that mid-ocean ridge basalts from...

journal_title：Nature

authors： Graham DW,Blichert-Toft J,Russo CJ,Rubin KH,Albarède F

更新日期：2006-03-09 00:00:00

abstract：:Vitamin A is required for normal growth and development, and retinoic acid (RA) may be the active metabolite in this process. Recent evidence indicates that RA acts through binding to a nuclear receptor which belongs to the steroid/thyroid hormone receptor superfamily. The receptors seem to associate with hormone-resp...

journal_title：Nature

authors： Bedo G,Santisteban P,Aranda A

更新日期：1989-05-18 00:00:00

abstract：:Bioluminescent symbioses range from facultative associations to highly adapted, apparently obligate ones. The family Anomalopidae (flashlight fishes) encompasses five genera of tropical reef fishes that have large suborbital light organs. The suborder Ceratioidei (deep-sea anglerfishes) contains 11 families. In nine o...

journal_title：Nature

authors： Haygood MG,Distel DL

更新日期：1993-05-13 00:00:00

abstract：:Numerous reports have emphasized the need for major changes in the global food system: agriculture must meet the twin challenge of feeding a growing population, with rising demand for meat and high-calorie diets, while simultaneously minimizing its global environmental impacts. Organic farming—a system aimed at produc...

journal_title：Nature

authors： Seufert V,Ramankutty N,Foley JA

更新日期：2012-05-10 00:00:00

abstract：:An ongoing challenge in chemical research is to design catalysts that select the outcomes of the reactions of complex molecules. Chemists rely on organocatalysts or transition metal catalysts to control stereoselectivity, regioselectivity and periselectivity (selectivity among possible pericyclic reactions). Nature ac...

journal_title：Nature

authors： Ohashi M,Jamieson CS,Cai Y,Tan D,Kanayama D,Tang MC,Anthony SM,Chari JV,Barber JS,Picazo E,Kakule TB,Cao S,Garg NK,Zhou J,Houk KN,Tang Y

更新日期：2020-10-01 00:00:00

abstract：:The transcription factor NF-kappaB is composed of homodimeric and heterodimeric complexes of Rel/NF-kappaB-family polypeptides, which include Rel-A, c-Rel, Rel-B, NF-kappaB/p50 and NF-kappaB2/p52 . The NF-kappaB1 gene encodes a larger precursor protein, p105, from which p50 is produced constitutively by proteasome-med...

journal_title：Nature

authors： Belich MP,Salmerón A,Johnston LH,Ley SC

更新日期：1999-01-28 00:00:00

abstract：:Practice, with feedback, is a fundamental variable that influences the aquisition of motor skills: with it, everyone improves, but some improve more than others. This simple fact has led to frequent debate over the relative importance of genetic and environmental influences on motor learning. In principle these factor...

journal_title：Nature

authors： Fox PW,Hershberger SL,Bouchard TJ Jr

更新日期：1996-11-28 00:00:00

abstract：:Daily life continually confronts us with an exuberance of external, sensory stimuli competing with a rich stream of internal deliberations, plans and ruminations. The brain must select one or more of these for further processing. How this competition is resolved across multiple sensory and cognitive regions is not kno...

journal_title：Nature

authors： Cerf M,Thiruvengadam N,Mormann F,Kraskov A,Quiroga RQ,Koch C,Fried I

更新日期：2010-10-28 00:00:00

abstract：:Haematopoiesis, the process of mature blood and immune cell production, is functionally organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent progenitor cells sitting at the very top. Multiple models have been proposed as to what the earliest lineage choices are in these primitive haem...

journal_title：Nature

authors： Rodriguez-Fraticelli AE,Wolock SL,Weinreb CS,Panero R,Patel SH,Jankovic M,Sun J,Calogero RA,Klein AM,Camargo FD

更新日期：2018-01-11 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-12-01 00:00:00

abstract：:'Long' gamma-ray bursts (GRBs) are commonly accepted to originate in the explosion of particularly massive stars, which give rise to highly relativistic jets. Inhomogeneities in the expanding flow result in internal shock waves that are believed to produce the gamma-rays we see. As the jet travels further outward into...

journal_title：Nature

authors： Tagliaferri G,Goad M,Chincarini G,Moretti A,Campana S,Burrows DN,Perri M,Barthelmy SD,Gehrels N,Krimm H,Sakamoto T,Kumar P,Mészáros PI,Kobayashi S,Zhang B,Angelini L,Banat P,Beardmore AP,Capalbi M,Covino S,Cusuman

更新日期：2005-08-18 00:00:00

abstract：:Early-life dietary transitions reflect fundamental aspects of primate evolution and are important determinants of health in contemporary human populations. Weaning is critical to developmental and reproductive rates; early weaning can have detrimental health effects but enables shorter inter-birth intervals, which inf...

journal_title：Nature

authors： Austin C,Smith TM,Bradman A,Hinde K,Joannes-Boyau R,Bishop D,Hare DJ,Doble P,Eskenazi B,Arora M

更新日期：2013-06-13 00:00:00

abstract：:T-cell lines established from individuals infected with human T-cell leukaemia virus (HTLV) or generated by co-cultivation of normal human T cells with HTLV-infected T-cells, express class II (HLA-D/DR or Ia) antigens of the major histocompatibility complex (MHC) and interleukin-2 (IL-2) receptors. Because the express...

journal_title：Nature

authors： Suciu-Foca N,Rubinstein P,Popovic M,Gallo RC,King DW

更新日期：1984-11-15 00:00:00

abstract：:The purification, renewal and differentiation of native cardiac progenitors would form a mechanistic underpinning for unravelling steps for cardiac cell lineage formation, and their links to forms of congenital and adult cardiac diseases. Until now there has been little evidence for native cardiac precursor cells in t...

journal_title：Nature

authors： Laugwitz KL,Moretti A,Lam J,Gruber P,Chen Y,Woodard S,Lin LZ,Cai CL,Lu MM,Reth M,Platoshyn O,Yuan JX,Evans S,Chien KR

更新日期：2005-02-10 00:00:00

abstract：:C-type (Ca(2+)-dependent) animal lectins such as mannose-binding proteins mediate many cell-surface carbohydrate-recognition events. The crystal structure at 1.7 A resolution of the carbohydrate-recognition domain of rat mannose-binding protein complexed with an oligomannose asparaginyl-oligosaccharide reveals that Ca...

journal_title：Nature

authors： Weis WI,Drickamer K,Hendrickson WA

更新日期：1992-11-12 00:00:00

abstract：:Drosophila mutants transformed with a chimaeric gene that expresses the ocellar visual pigment in the major class of photoreceptor cells of the retina were used to investigate the properties of this minor pigment. The photoreceptor cells in which this opsin was misexpressed showed new spectral characteristics and phys...

journal_title：Nature

authors： Feiler R,Harris WA,Kirschfeld K,Wehrhahn C,Zuker CS

更新日期：1988-06-23 00:00:00

abstract：: ...

journal_title：Nature

authors： Tall AR,Jelic S

更新日期：2019-02-01 00:00:00

abstract：:Rivers sourced in the Himalayan mountain range carry some of the largest sediment loads on the planet, yet coarse gravel in these rivers vanishes within approximately 10-40 kilometres on entering the Ganga Plain (the part of the North Indian River Plain containing the Ganges River). Understanding the fate of gravel is...

journal_title：Nature

authors： Dingle EH,Attal M,Sinclair HD

更新日期：2017-04-26 00:00:00

abstract：:Optical laser fields have been widely used to achieve quantum control over the motional and internal degrees of freedom of atoms and ions, molecules and atomic gases. A route to controlling the quantum states of macroscopic mechanical oscillators in a similar fashion is to exploit the parametric coupling between optic...

journal_title：Nature

authors： Verhagen E,Deléglise S,Weis S,Schliesser A,Kippenberg TJ

更新日期：2012-02-01 00:00:00

abstract：:An ageing world population has fuelled interest in regenerative remedies that may stem declining organ function and maintain fitness. Unanswered is whether elimination of intrinsic instigators driving age-associated degeneration can reverse, as opposed to simply arrest, various afflictions of the aged. Such instigator...

journal_title：Nature

authors： Jaskelioff M,Muller FL,Paik JH,Thomas E,Jiang S,Adams AC,Sahin E,Kost-Alimova M,Protopopov A,Cadiñanos J,Horner JW,Maratos-Flier E,Depinho RA

更新日期：2011-01-06 00:00:00