The basolateral nucleus of the amygdala mediates caloric sugar preference over a non-caloric sweetener in mice.


:Neurobiological and genetic mechanisms underlying increased intake of and preference for nutritive sugars over non-nutritive sweeteners are not fully understood. We examined the roles of subnuclei of the amygdala in the shift in preference for a nutritive sugar. Food-deprived mice alternately received caloric sucrose (1.0 M) on odd-numbered training days and a non-caloric artificial sweetener (2.5 mM saccharin) on even-numbered training days. During training, mice with sham lesions of the basolateral (BLA) or central (CeA) nucleus of the amygdala increased their intake of 1.0 M sucrose, but not saccharin. Trained mice with sham lesions showed a significant shift in preference toward less concentrated sucrose (0.075 M) over the saccharin in a two-bottle choice test, although the mice showed an equivalent preference for these sweeteners before training. No increased intake of or preference for sucrose before and after the alternating training was observed in non-food-deprived mice. Excitotoxic lesions centered in the BLA impaired the increase in 1.0M sucrose intake and shift in preference toward 0.075 M sucrose over saccharin. Microlesions with iontophoretic excitotoxin injections into the CeA did not block the training-dependent changes. These results suggest that food-deprived animals selectively shift their preference for a caloric sugar over a non-caloric sweetener through the alternate consumption of caloric and non-caloric sweet substances. The present data also suggest that the BLA, but not CeA, plays a role in the selective shift in sweetener preference.






Yasoshima Y,Yoshizawa H,Shimura T,Miyamoto T




Has Abstract


2015-04-16 00:00:00












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    pub_type: 杂志文章


    authors: Zhou H,Geng F,Wang T,Wang C,Xie Y,Hu Y,Chen F

    更新日期:2020-04-15 00:00:00

  • Treadmill exercise enhances synaptic plasticity, but does not alter β-amyloid deposition in hippocampi of aged APP/PS1 transgenic mice.

    abstract::Several studies reveal that the beneficial effects of exercise interventions are dependent on the progression of Alzheimer's disease (AD). We have previously shown that long-term treadmill exercise begun before the onset of β-amyloid (Aβ) pathology prevents the deficits of cognition and long-term potentiation (LTP) in...


    pub_type: 杂志文章


    authors: Zhao G,Liu HL,Zhang H,Tong XJ

    更新日期:2015-07-09 00:00:00

  • Experience-dependent regulation of synaptic zinc is impaired in the cortex of aged mice.

    abstract::Zinc plays an important role in synaptic signaling in the mammalian cerebral cortex. Zinc is sequestered into presynaptic vesicles of subpopulations of glutamatergic neurons and is released by depolarization, in a calcium-dependent manner. As the majority of mechanisms that have been suggested to participate in experi...


    pub_type: 杂志文章


    authors: Brown CE,Dyck RH

    更新日期:2003-01-01 00:00:00

  • Closed-head minimal traumatic brain injury produces long-term cognitive deficits in mice.

    abstract::Victims of minimal traumatic brain injury (mTBI) do not show clear morphological brain defects, but frequently suffer lasting cognitive deficits, emotional difficulties and behavioral disturbances. In the present study we adopted a non-invasive closed-head weight-drop mouse model to produce mTBI. We examined the effec...


    pub_type: 杂志文章


    authors: Zohar O,Schreiber S,Getslev V,Schwartz JP,Mullins PG,Pick CG

    更新日期:2003-01-01 00:00:00

  • Vesicular glutamate transporters type 1 and 2 expression in axon terminals of the rat nucleus of the solitary tract.

    abstract::The nucleus of the solitary tract is the site of termination of primary afferent fibers running in the facial, glossopharyngeal and vagus nerves. The present study was performed to map the distribution of glutamatergic axons terminals in the rat nucleus of the solitary tract using immunodetection of vesicular glutamat...


    pub_type: 杂志文章


    authors: Lachamp P,Crest M,Kessler JP

    更新日期:2006-01-01 00:00:00

  • Investigating motor initiation and inhibition deficits in patients with Parkinson's disease and freezing of gait using a virtual reality paradigm.

    abstract::Freezing of gait (FOG) is a common, disabling symptom of Parkinson's disease (PD) that is associated with deficits in motor initiation and inhibition. Understanding of underlying neurobiological mechanisms has been limited by difficulties in eliciting and objectively characterizing such gait phenomena in the clinical ...


    pub_type: 杂志文章


    authors: Georgiades MJ,Gilat M,Ehgoetz Martens KA,Walton CC,Bissett PG,Shine JM,Lewis SJ

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  • Effects of granulocyte colony-stimulating factor on the proliferation and cell-fate specification of neural stem cells.

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    pub_type: 杂志文章


    authors: Liu H,Jia D,Fu J,Zhao S,He G,Ling EA,Gao J,Hao A

    更新日期:2009-12-29 00:00:00

  • Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway.

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    pub_type: 杂志文章


    authors: Zhou CJ,Borello U,Rubenstein JL,Pleasure SJ

    更新日期:2006-11-03 00:00:00

  • Hierarchical Organization Within the Ventral Premotor Cortex of the Macaque Monkey.

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    pub_type: 杂志文章,评审


    authors: Kurata K

    更新日期:2018-07-01 00:00:00

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    pub_type: 杂志文章


    authors: Lou M,Zhang H,Wang J,Wen SQ,Tang ZQ,Chen YZ,Yan WQ,Ding MP

    更新日期:2007-05-11 00:00:00

  • Effect of neurotoxic lesion of pedunculopontine nucleus in nigral and striatal redox balance and motor performance in rats.

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    pub_type: 杂志文章


    authors: Jimenez-Martin J,Blanco-Lezcano L,González-Fraguela ME,Díaz-Hung ML,Serrano-Sánchez T,Almenares JL,Francis-Turner L

    更新日期:2015-03-19 00:00:00

  • Precisely timed spatiotemporal patterns of neural activity in dissociated cortical cultures.

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    pub_type: 杂志文章


    authors: Rolston JD,Wagenaar DA,Potter SM

    更新日期:2007-08-10 00:00:00

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    pub_type: 杂志文章


    authors: Pauli-Magnus D,Hoch G,Strenzke N,Anderson S,Jentsch TJ,Moser T

    更新日期:2007-11-09 00:00:00

  • Nicotinic cholinergic activation of magnocellular neurons of the hypothalamic paraventricular nucleus.

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    pub_type: 杂志文章


    authors: Zaninetti M,Tribollet E,Bertrand D,Raggenbass M

    更新日期:2002-01-01 00:00:00

  • Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus.

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    pub_type: 杂志文章


    authors: Hassani OK,Mouroux M,Féger J

    更新日期:1996-05-01 00:00:00

  • Diabetes-induced Neuropathic Mechanical Hyperalgesia Depends on P2X4 Receptor Activation in Dorsal Root Ganglia.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Millar TJ,Salipan N,Oliver JO,Morgan IG,Chubb IW

    更新日期:1984-09-01 00:00:00

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    pub_type: 杂志文章


    authors: Reid MS,Herrera-Marschitz M,Ungerstedt U

    更新日期:1990-01-01 00:00:00

  • Heterologous expression of the invertebrate FMRFamide-gated sodium channel as a mechanism to selectively activate mammalian neurons.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Mehta A,Menalled L,Chesselet MF

    更新日期:2005-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Balaban CD,Schuerger RJ,Porter JD

    更新日期:2000-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Bartlett EL,Smith PH

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    pub_type: 杂志文章


    authors: Sanchez-Toscano F,Caminero AA,Machin C,Abella G

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    pub_type: 杂志文章


    authors: Kalivas PW,Burgess SK,Nemeroff CB,Prange AJ Jr

    更新日期:1983-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Hoffman GE,Gibbs FP

    更新日期:1982-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Korsak A,Gilbey MP

    更新日期:2004-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Takemura M,Wakisaka S,Yoshida A,Nagase Y,Bae YC,Shigenaga Y

    更新日期:1994-08-01 00:00:00

  • Postweaning Enriched Environment Enhances Cognitive Function and Brain-Derived Neurotrophic Factor Signaling in the Hippocampus in Maternally Separated Rats.

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    pub_type: 杂志文章


    authors: Cordier JM,Aguggia JP,Danelon V,Mir FR,Rivarola MA,Mascó D

    更新日期:2021-01-15 00:00:00

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    pub_type: 杂志文章


    authors: Przewłocki R,Hassan AH,Lason W,Epplen C,Herz A,Stein C

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    abstract::Extracellular levels of GABA, derived from cell suspension transplants of embryonic day 14-15 rat striatal primordia implanted into the previously excitotoxically lesioned striatum, were measured using intracerebral microdialysis in halothane-anaesthetized rats. GABA overflow was monitored using loop type dialysis pro...


    pub_type: 杂志文章


    authors: Campbell K,Kalén P,Wictorin K,Lundberg C,Mandel RJ,Björklund A

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