Abstract:
:Retinoic acid is a potent cell differentiating factor, which through its nuclear receptors affects a vast range of promoter sites in brain neuronal and glial cells in every step of embryonic and postnatal life. Its capacities, facilitating maturation of neurotransmitter phenotype in different groups of neurons, pave the way for its application as a potential therapeutic agent in neurodegenerative diseases including Alzheimer's disease. Retinoic acid was found to exert particularly strong enhancing effects on acetylcholine transmitter functions in brain cholinergic neurons, loss of which is tightly linked to the development of cognitive and memory deficits in course of different cholinergic encephalopathies. Here, we review cholinotrophic properties of retinoic acid and its derivatives, which may justify their application in the management of Alzheimer's disease and the related neurodegenerative conditions.
journal_name
Expert Rev Neurotherjournal_title
Expert review of neurotherapeuticsauthors
Szutowicz A,Bielarczyk H,Jankowska-Kulawy A,Ronowska A,Pawełczyk Tdoi
10.1586/14737175.2015.1008456subject
Has Abstractpub_date
2015-03-01 00:00:00pages
239-49issue
3eissn
1473-7175issn
1744-8360journal_volume
15pub_type
杂志文章,评审abstract::Nausea and vomiting continue to present significant problems for cancer patients undergoing chemotherapy. Initial work suggested an important role for central dopamine transmission in the underlying pathophysiology. However, recent evidence has implicated central and peripheral serotonin release. Although the implemen...
journal_title:Expert review of neurotherapeutics
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doi:10.1586/14737175.3.1.77
更新日期:2003-01-01 00:00:00
abstract::Dysregulation of the mTOR signaling pathway is associated with highly epileptogenic conditions such as tuberous sclerosis, focal cortical dysplasia, hemimegalencephaly and ganglioglioma, grouped under the term of 'mTORopathies'. Brain abnormalities associated with mTOR overactivation include enlarged and dysplastic ne...
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journal_title:Expert review of neurotherapeutics
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journal_title:Expert review of neurotherapeutics
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journal_title:Expert review of neurotherapeutics
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journal_title:Expert review of neurotherapeutics
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journal_title:Expert review of neurotherapeutics
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
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journal_title:Expert review of neurotherapeutics
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更新日期:2009-06-01 00:00:00
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journal_title:Expert review of neurotherapeutics
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1586/14737175.4.5.831
更新日期:2004-09-01 00:00:00
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journal_title:Expert review of neurotherapeutics
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更新日期:2011-02-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/ern.12.109
更新日期:2012-10-01 00:00:00
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journal_title:Expert review of neurotherapeutics
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/14737175.6.10.1511
更新日期:2006-10-01 00:00:00
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journal_title:Expert review of neurotherapeutics
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doi:10.1586/14737175.2013.846520
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
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更新日期:2008-11-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/14737175.8.2.235
更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1586/14737175.3.5.591
更新日期:2003-09-01 00:00:00
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journal_title:Expert review of neurotherapeutics
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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