Anaplastic glioma: current treatment and management.

Abstract:

:Anaplastic glioma (AG) is divided into three morphology-based groups (anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma) as well as three molecular groups (glioma-CpG island methylation phenotype [G-CIMP] negative, G-CIMP positive non-1p19q codeleted tumors and G-CIMP positive codeleted tumors). The RTOG 9402 and EORTC 26951 trials established radiotherapy plus (procarbazine, lomustine, vincristine) chemotherapy as the standard of care in 1p/19q codeleted AG. Uni- or non-codeleted AG are currently best treated with radiotherapy only or alkylator-based chemotherapy only as determined by the NOA-04 trial. Maturation of NOA-04 and results of the currently accruing studies, CODEL (for codeleted AG) and CATNON (for uni or non-codeleted AG), will likely refine current up-front treatment recommendations for AG.

journal_name

Expert Rev Neurother

authors

Le Rhun E,Taillibert S,Chamberlain MC

doi

10.1586/14737175.2015.1042455

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

601-20

issue

6

eissn

1473-7175

issn

1744-8360

journal_volume

15

pub_type

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