Abstract:
:Cerebral folate deficiency is defined as any neurological condition associated with low cerebrospinal fluid folate concentrations. It is becoming increasingly associated with several neurological diseases, either genetic or environmental. Treatment of cerebral folate deficiency by folate supplementation is generally effective, improving the neurological outcome of some patients. However, to treat cerebral folate deficiency, the proper choice of one of the available folate forms is essential. The distinct brain folate metabolism features compared with peripheral folate metabolic pathways strongly suggest the investigation of different folate forms, such as the biologically active folinic acid and 5-methyltetrahydrofolate, since they are efficiently transported to the brain. Regarding the oral doses of the different folate forms, despite the fact that there are some recommendations, there is no general consensus. Further investigation and designing clinical trials are advisable to elucidate these aspects.
journal_name
Expert Rev Neurotherjournal_title
Expert review of neurotherapeuticsauthors
Molero-Luis M,Serrano M,O'Callaghan MM,Sierra C,Pérez-Dueñas B,García-Cazorla A,Artuch Rdoi
10.1586/14737175.2015.1055322subject
Has Abstractpub_date
2015-01-01 00:00:00pages
793-802issue
7eissn
1473-7175issn
1744-8360journal_volume
15pub_type
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journal_title:Expert review of neurotherapeutics
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