Abstract:
:Babies born to mothers exposed to antiepileptic drugs (AEDs) are at increased risk for major congenital malformations, cognitive impairment and fetal death. For the millions of women with epilepsy, maintaining the safest drug that will successfully prevent seizures during pregnancy remains a primary consideration. The recent development of collaborative international registries to examine the differential and dose-dependent effects of the expanding number of old and new AEDs, have shed light upon potential differences during pregnancy. Valproic acid appears to be associated with the highest risk of overall, as well as AED-specific, birth defects, becoming more evident as doses exceed 1000 mg/day. Lamotrigine may be less teratogenic to humans than other AEDs, although orofacial clefts have recently been reported. The effects of polytherapy appear to carry greater risks compared with monotherapy. Limited data exist for many of the newer AEDs. Furthermore, AED effects may persist during postnatal development. Although no class 1 outcome data are available, prepregnancy counseling to optimize patient-specific treatment is recommended for women of childbearing potential with epilepsy.
journal_name
Expert Rev Neurotherjournal_title
Expert review of neurotherapeuticsauthors
Tatum WOdoi
10.1586/14737175.6.7.1077subject
Has Abstractpub_date
2006-07-01 00:00:00pages
1077-86issue
7eissn
1473-7175issn
1744-8360journal_volume
6pub_type
杂志文章,评审abstract::Dual-task (DT) circumstances aggravate gait disorders in Parkinson's disease (PD) and are associated with an increased risk of falling and reduced functional mobility. Clinical rehabilitation guidelines for PD consider DT interventions as potentially hazardous and recommend avoiding them in daily life. The current art...
journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Expert review of neurotherapeutics
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更新日期:2011-12-01 00:00:00
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journal_title:Expert review of neurotherapeutics
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journal_title:Expert review of neurotherapeutics
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doi:10.1586/ern.10.200
更新日期:2011-02-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/14737175.5.6.831
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journal_title:Expert review of neurotherapeutics
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doi:10.1586/14737175.4.3.425
更新日期:2004-05-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/14737175.7.9.1105
更新日期:2007-09-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type:
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更新日期:2010-08-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/14737175.2015.1028370
更新日期:2015-04-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1080/14737175.2019.1564042
更新日期:2019-02-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/ern.13.33
更新日期:2013-05-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/14737175.6.7.945
更新日期:2006-07-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1080/14737175.2016.1194756
更新日期:2016-08-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章
doi:10.1586/14737175.8.4.575
更新日期:2008-04-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/14737175.5.6.721
更新日期:2005-11-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/14737175.2015.988709
更新日期:2015-01-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章
doi:10.1586/14737175.3.2.233
更新日期:2003-03-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/ern.11.63
更新日期:2011-08-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章
doi:10.1586/14737175.2.5.731
更新日期:2002-09-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1080/14737175.2019.1585243
更新日期:2019-03-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 评论,杂志文章
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更新日期:2011-09-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/14737175.5.3.371
更新日期:2005-05-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/14737175.7.6.667
更新日期:2007-06-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/14737175.5.6.S41
更新日期:2005-11-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 评论,杂志文章
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更新日期:2011-08-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1080/14737175.2019.1629290
更新日期:2019-07-01 00:00:00
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journal_title:Expert review of neurotherapeutics
pub_type: 杂志文章,评审
doi:10.1586/14737175.7.7.829
更新日期:2007-07-01 00:00:00