Improvement of gait and balance by non-invasive brain stimulation: its use in rehabilitation.

abstract：:Acute pain informs the individual that there is an imminent threat of body damage, and is associated with the urge to escape and avoid. Fear learning takes place when neutral stimuli receive the propensity to predict the occurrence of pain, and when defensive responses are initiated in anticipation of potential threat...

journal_title：Expert review of neurotherapeutics

authors： den Hollander M,de Jong JR,Volders S,Goossens ME,Smeets RJ,Vlaeyen JW

更新日期：2010-11-01 00:00:00

abstract：:Introduction: Cognitive impairment and behavioral disturbances are common findings in Parkinson's disease (PD). Despite initially being considered late complications of the disease, it is currently accepted that almost all PD patients will exhibit cognitive and behavioral abnormalities from the early and even the prem...

journal_title：Expert review of neurotherapeutics

authors： Martinez-Horta S,Horta-Barba A,Kulisevsky J

更新日期：2019-07-01 00:00:00

abstract：:The saga of harmful administration of levodopa (LD) in the treatment of Parkinson's disease (PD) resulted from outcomes of animal trials and cell culture studies. They were initiated after the clinical observation of onset of motor complications related to the short plasma half-life of the drug in PD patients. This di...

journal_title：Expert review of neurotherapeutics

authors： Müller T

更新日期：2008-06-01 00:00:00

abstract：INTRODUCTION:Non-convulsive status epilepticus (NCSE) is a complex and diverse condition which is often an under-recognised entity in the intensive care unit. When NCSE is identified the optimal treatment strategy is not always clear. Areas covered: This review is based on a literature review of the key literature in t...

journal_title：Expert review of neurotherapeutics

authors： Kinney MO,Kaplan PW

更新日期：2017-10-01 00:00:00

abstract：:Translation of the analgesic efficacy of investigational neurotherapeutics from pre-clinical pain models into clinical trial phases is associated with a high risk of failure. Application of human pain biomarkers in early stages of clinical trials can potentially enhance the rate of successful translation, which would ...

journal_title：Expert review of neurotherapeutics

authors： Arendt-Nielsen L,Nielsen TA,Gazerani P

更新日期：2014-03-01 00:00:00

abstract：INTRODUCTION:Antipsychotics have long been the mainstay of treatment for agitation and psychosis in Alzheimer's disease. Despite their current use successive studies have shown that they only confer a modest benefit which must be balanced against their well-established serious side effects (extrapyramidal symptoms, str...

journal_title：Expert review of neurotherapeutics

authors： Creese B,Da Silva MV,Johar I,Ballard C

更新日期：2018-06-01 00:00:00

abstract：:Pseudotumor cerebri (PTC) is characterized by intracranial hypertension without ventriculomegaly, in the absence of a mass lesion or meningeal process. When there is no secondary cause, it is termed 'idiopathic intracranial hypertension'. Headache is the most common symptom of PTC, present in over 90% of patients. The...

journal_title：Expert review of neurotherapeutics

authors： Friedman DI

更新日期：2008-03-01 00:00:00

abstract：:Gliomas constitute the most frequent and malignant primary brain tumors. Current standard therapeutic strategies (surgery, radiotherapy and chemotherapeutics, e.g., temozolomide, carmustin or carboplatin) for their treatment are only palliative and survival diagnosis is normally 6-12 months. The development of new the...

journal_title：Expert review of neurotherapeutics

authors： Parolaro D,Massi P

更新日期：2008-01-01 00:00:00

abstract：:Intraoral splints are effective in migraine prevention. In this review, changes in the quality of life of migraineurs treated with a palatal nonoccluding splint were measured. Using the Migraine Specific Quality of Life Instrument (Version 2.1), it was found that the palatal nonoccluding splint significantly improved ...

journal_title：Expert review of neurotherapeutics

authors： Shevel E

更新日期：2005-05-01 00:00:00

abstract：:Persistent gait deficits after stroke can cause falls, elevated energy cost and poor endurance. Coordination impairment is an underlying cause of gait deficits. Few efficacious interventions have been described that have targeted and measured restoration of coordinated gait components. Neuromuscular electrical stimula...

journal_title：Expert review of neurotherapeutics

authors： Daly JJ

更新日期：2006-10-01 00:00:00

abstract：:Recent morphometric MRI studies have investigated brain volume abnormalities associated with the diagnosis of Alzheimer's disease (AD) using voxel-based morphometry (VBM). This technique allows the assessment of gray matter volumes in subjects with AD or related conditions compared with healthy controls in an automate...

journal_title：Expert review of neurotherapeutics

authors： Busatto GF,Diniz BS,Zanetti MV

更新日期：2008-11-01 00:00:00

abstract：:Genetic imaging has become an increasingly popular tool that utilizes neuroimaging techniques to investigate the impact of genetic variation on the structure, function and connectivity of the brain. Combining genetic and neuroimaging domains is a promising approach to further the understanding of the neural mechanisms...

journal_title：Expert review of neurotherapeutics

authors： Redpath HL,Lawrie SM,Sprooten E,Whalley HC,McIntosh AM,Hall J

更新日期：2013-01-01 00:00:00

abstract：:Fingolimod is the first oral agent approved in the USA for the treatment of relapsing forms of multiple sclerosis. Fingolimod is a sphingosine 1-phosphate receptor modulator that binds to sphingosine 1-phosphate receptors on lymphocytes, resulting in a downregulation of the receptor and a reversible sequestration of l...

journal_title：Expert review of neurotherapeutics

authors： Jeffery DR,Markowitz CE,Reder AT,Weinstock-Guttman B,Tobias K

更新日期：2011-02-01 00:00:00

abstract：:Stroke is the third leading cause of mortality in the USA and one of the leading causes of severe morbidity. It is important to provide stroke patients and physicians with the most accurate prognostic information to optimize care and allocation of healthcare resources. Reliable prognostic markers available during the ...

journal_title：Expert review of neurotherapeutics

authors： Katan M,Elkind MS

更新日期：2011-02-01 00:00:00

abstract：:The aim of this article is to provide an overview on neuromuscular blocking agents and a rational selection of the most appropriate agents, along with pharmacological and pharmacoeconomic considerations on neuromuscular blockers and their antagonists. Neuromuscular blocking agents are used during anesthesia to facilit...

journal_title：Expert review of neurotherapeutics

authors： Leykin Y,Pellis T,Vincenti E

更新日期：2006-12-01 00:00:00

abstract：:Evaluation of: Segal BM, Constantinescu CS, Raychaudhuri A et al. Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a Phase II, double-blind, placebo-controlled, randomized, dose-ranging study. Lancet Neurol. 7, 796-804 (2008). ...

journal_title：Expert review of neurotherapeutics

authors： Longbrake EE,Racke MK

更新日期：2009-03-01 00:00:00

abstract：:This review will update current views of the physiopathology and treatment of fatigue in multiple sclerosis. Fatigue is a common symptom in multiple sclerosis, being reported by about a third of the patients. For many of them it is the most disabling symptom, with negative consequences on working activity and daily li...

journal_title：Expert review of neurotherapeutics

authors： Comi G,Leocani L

更新日期：2002-11-01 00:00:00

abstract：:Estrogens fluctuations, particularly their premenstrual fall, are currently regarded as the main triggers of menstrual migraine (MM). MM presents in two clinical forms: pure MM, where attacks are confined to the perimenstrual period (PMP), and menstrually related migraine, where attacks always occur during, but are no...

journal_title：Expert review of neurotherapeutics

authors： Allais G,Castagnoli Gabellari I,De Lorenzo C,Mana O,Benedetto C

更新日期：2007-09-01 00:00:00

abstract：:Alzheimer's disease is the most common form of neurodegenerative dementia and poses considerable health challenges to both patients and their families. Rivastigmine is a powerful slow-reversible, noncompetitive carbamate cholinesterase inhibitor that is approved for the treatment of mild-to-moderate Alzheimer's diseas...

journal_title：Expert review of neurotherapeutics

authors： Desai AK,Grossberg GT

更新日期：2005-09-01 00:00:00

abstract：:Side effects to antiparkinsonian drugs constitute an important component of the daily management of patients with Parkinson's disease. Treatment with levodopa frequently leads to motor fluctuations and dyskinesias. Hallucinosis, nausea and vomiting, drowsiness, orthostatic hypotension and peripheral edema can be manag...

journal_title：Expert review of neurotherapeutics

authors： Singer C

更新日期：2002-01-01 00:00:00

abstract：:Lennox-Gastaut syndrome is a relatively rare epilepsy syndrome that usually begins in early-mid childhood and is characterized by multiple seizure types, particularly generalized seizures, which are often resistant to antiepileptic drug medication. Rufinamide is a new antiepileptic drug approved as adjunctive therapy ...

journal_title：Expert review of neurotherapeutics

authors： Ferrie CD

更新日期：2010-06-01 00:00:00

abstract：:Cortical spreading depression (CSD) has been at the center stage of migraine pathophysiology for approximately six decades. Reanalysis of CSD reveals several major unbridgeable gaps in this experimental neurophysiologic concept for migraine. Key phenotypic and pharmacological features of migraine challenge the assumed...

journal_title：Expert review of neurotherapeutics

authors： Gupta VK

更新日期：2009-11-01 00:00:00

abstract：:Hypertension is an important risk factor for stroke. The latter results in disability and premature death and represents a major public health problem. Various studies have established a strong relationship between increasing blood pressure and stroke risk, as well as clear evidence of a reduction in the incidence of ...

journal_title：Expert review of neurotherapeutics

authors： Karthikeyan VJ,Lip GY

更新日期：2006-02-01 00:00:00

abstract：:Background: Triptanophobia is the excessive and inadequately justified concern about potential risks of triptans. We evaluated causes and consequences of nonuse of triptans in chronic migraine (CM) Methods: Case-control study. We included CM patients firstly referred to aheadache unit. Patients were cases or controls ...

journal_title：Expert review of neurotherapeutics

authors： Martínez-Pías E,García-Azorín D,Minguez-Olaondo A,Trigo J,Sierra Á,Ruiz M,Guerrero ÁL

更新日期：2021-01-01 00:00:00

abstract：INTRODUCTION:Pharmaceutical companies and the NIH have invested heavily in a variety of potential disease-modifying therapies for Alzheimer's disease (AD) but unfortunately all double-blind placebo-controlled Phase III studies of these drugs have failed to show statistically significant results supporting their clinica...

journal_title：Expert review of neurotherapeutics

authors： Amanatkar HR,Papagiannopoulos B,Grossberg GT

更新日期：2017-01-01 00:00:00

abstract：:Genetic analysis is providing new information on the biological basis of epilepsy at a rapid pace; this article identifies factors acting as major barriers to use of these data for therapy development. Disease heterogeneity is a primary obstacle since so many genes can cause or predispose to epilepsy and the clinical ...

journal_title：Expert review of neurotherapeutics

authors： Ferraro TN

更新日期：2016-01-01 00:00:00

abstract：:Millions of people worldwide suffer from diseases that result from a failure of central pathways to regulate behavioral and physiological processes. Advances in genetics and pharmacology have already allowed us to appreciate that rather than this dysregulation being systemic throughout the brain, it is usually rooted ...

journal_title：Expert review of neurotherapeutics

authors： Whittle AJ,Walsh J,de Lecea L

更新日期：2014-09-01 00:00:00

abstract：:Recent evidence suggests that active trigger points (TrPs) in neck and shoulder muscles contribute to tension-type headache. Active TrPs within the suboccipital, upper trapezius, sternocleidomastoid, temporalis, superior oblique and lateral rectus muscles have been associated with chronic and episodic tension-type hea...

journal_title：Expert review of neurotherapeutics

authors： Alonso-Blanco C,de-la-Llave-Rincón AI,Fernández-de-las-Peñas C

更新日期：2012-03-01 00:00:00

abstract：:Panic disorder is one of the most common anxiety disorders and has a lifetime prevalence of 3-5%. Panic attacks can begin at any age, but commonly have their onset in early adulthood between the ages of 20 and 40 years. Naturalistic data has shown that panic disorder has a chronic and relapsing course. Panic disorder ...

journal_title：Expert review of neurotherapeutics

authors： Dannon PN,Lowengrub K,Iancu I,Kotler M

更新日期：2004-03-01 00:00:00

abstract：:The third part of this in-depth review series on the treatment of multiple sclerosis (MS) with monoclonal antibodies covers the years 2010-2012. The natalizumab section gives a progressive multifocal leukoencephalopathy update, focusing on clinically relevant aspects. Furthermore, it outlines problems around natalizum...

journal_title：Expert review of neurotherapeutics

authors： Deiß A,Brecht I,Haarmann A,Buttmann M

更新日期：2013-03-01 00:00:00