Depression and randomized, controlled trials: problems and solutions.

abstract：:The prevalence rate of chronic pain is 15% to 25% in adults while the therapeutic arsenal is still insufficient, especially in relieving neuropathic pain. Peripheral pain transmission is conducted by the small Aδ and C sensory nerve fibres. They express elements from the renin-angiotensin-aldosterone system (RAAS), a ...

journal_title：Expert review of neurotherapeutics

authors： Bessaguet F,Magy L,Desmoulière A,Demiot C

更新日期：2016-01-01 00:00:00

abstract：:Pain is one of the most troublesome sequelae of stroke, occurring in 19-74% of patients. A portion of this post-stroke pain is caused by the brain lesion itself; this is called 'central post-stroke pain' (CPSP). Although the prevalence of CPSP among stroke patients is low (1-8%), the persistent, often treatment-refrac...

journal_title：Expert review of neurotherapeutics

authors： Kim JS

更新日期：2009-05-01 00:00:00

abstract：:Sumatriptan 85 mg with naproxen sodium 500 mg, a combination tablet for the acute treatment of migraine, is approved in the USA. It is likely that triptan/NSAID combination benefits are a class effect, although the majority of data are on sumatriptan and naproxen sodium. The combination tablet demonstrated superior ef...

journal_title：Expert review of neurotherapeutics

authors： Cleves C,Tepper SJ

更新日期：2008-09-01 00:00:00

abstract：INTRODUCTION:Multiple Sclerosis is a chronic inflammatory demyelinating disease that affects 2.5 million people in the world. NEDA (No evidence of disease Activity) -4 is a new concept related to absence of disease activity in the context of MS. It takes into account the following four parameters: relapses; disability ...

journal_title：Expert review of neurotherapeutics

authors： Matta AP,Nascimento OJ,Ferreira AC,Magalhães TN,Benevides TP,Kirmse A,Dib JG,Cal H,Orsini M,Araujo LM

更新日期：2016-11-01 00:00:00

abstract：:Introduction: Most preventive migraine treatments modify the brain's excitation/inhibition balance and/or serotonin metabolism, which likely accounts for their unfavorable adverse effect profile. Novel biological therapies blocking CGRP transmission are effective and better tolerated, but they are expensive and may no...

journal_title：Expert review of neurotherapeutics

authors： Lisicki M,Schoenen J

更新日期：2020-03-01 00:00:00

abstract：:The term cervicogenic headache (CeH) describes a syndrome originating from the cervical spine. There are a variety of therapeutic approaches used for the management of CeH, but scientific evidence of their effectiveness is scarce. No medication drug has proven to be effective. The evidence for greater occipital nerve ...

journal_title：Expert review of neurotherapeutics

authors： Fernández-de-las-Peñas C,Cuadrado ML

更新日期：2014-01-01 00:00:00

abstract：:Management issues for patients with brain tumors include peritumoral edema, symptomatic seizures, venous thromboembolism, headache, pain, fatigue and neuropsychological complaints. Vasogenic edema is typically ameliorated with the lowest dose possible of corticosteroid. Seizures are managed with attention to additiona...

journal_title：Expert review of neurotherapeutics

authors： Daly FN,Schiff D

更新日期：2007-10-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disorder characterized by CNS inflammation, demyelination and cellular damage with atrophy. Most patients with MS initially present with a relapsing-remitting course, with periodic episodes of neurologic symptomatology that do not follow a predictable pattern. In order to maint...

journal_title：Expert review of neurotherapeutics

authors： Fox EJ

更新日期：2010-12-01 00:00:00

abstract：:Guillain-Barré syndrome (GBS) includes demyelinating and axonal subtypes with different immunopathologic mechanisms. In acute inflammatory demyelinating polyradiculoneuropathy, segmental demyelination and conduction block are the pathological and electrophysiological correlates of muscle weakness. Slowed conductions a...

journal_title：Expert review of neurotherapeutics

authors： Uncini A,Yuki N

更新日期：2009-06-01 00:00:00

abstract：:Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral condition that impairs functioning throughout childhood and adolescence. Evidence-based guidelines for the treatment of ADHD recommend recognizing ADHD as a chronic condition. The chronic care model for child health emphasizes the need for pro...

journal_title：Expert review of neurotherapeutics

authors： Brinkman WB,Epstein JN

更新日期：2011-04-01 00:00:00

abstract：:Advances in neuroscience have led to an expanded and improved understanding of neurobiological changes associated with rehabilitation and exercise in Parkinson's disease (PD). This knowledge has led to a direct clinical impact of increased referral for early and continuous exercise programs for individuals with PD (ph...

journal_title：Expert review of neurotherapeutics

authors： Sapir S,Ramig LO,Fox CM

更新日期：2011-06-01 00:00:00

abstract：:This review will update current views of the physiopathology and treatment of fatigue in multiple sclerosis. Fatigue is a common symptom in multiple sclerosis, being reported by about a third of the patients. For many of them it is the most disabling symptom, with negative consequences on working activity and daily li...

journal_title：Expert review of neurotherapeutics

authors： Comi G,Leocani L

更新日期：2002-11-01 00:00:00

abstract：:The aim of stem cell therapy for Parkinson's disease is to reconstruct nigro-striatal neuronal pathways using endogenous neural stem/precursor cells or grafted dopaminergic neurons. As an alternative, transplantation of stem cell-derived dopaminergic neurons into the striatum has been attempted, with the aim of stimul...

journal_title：Expert review of neurotherapeutics

authors： Takahashi J

更新日期：2007-06-01 00:00:00

abstract：INTRODUCTION:Deep brain stimulation (DBS) has become a standard therapy for the treatment of select cases of medication refractory essential tremor and Parkinson's disease however the effectiveness and long-term outcomes of DBS in other uncommon and complex tremor syndromes has not been well established. Traditionally,...

journal_title：Expert review of neurotherapeutics

authors： Ramirez-Zamora A,Okun MS

更新日期：2016-08-01 00:00:00

abstract：:Introduction: The microbiota-gut brain (MGB) axis is the bidirectional communication between the intestinal microbiota and the brain. An increasing body of preclinical and clinical evidence has revealed that the gut microbial ecosystem can affect neuropsychiatric health. However, there is still a need of further studi...

journal_title：Expert review of neurotherapeutics

authors： Iannone LF,Preda A,Blottière HM,Clarke G,Albani D,Belcastro V,Carotenuto M,Cattaneo A,Citraro R,Ferraris C,Ronchi F,Luongo G,Santocchi E,Guiducci L,Baldelli P,Iannetti P,Pedersen S,Petretto A,Provasi S,Selmer K,Sp

更新日期：2019-10-01 00:00:00

abstract：:Understanding of the structure and function of the endocannabinoid system is rapidly evolving. Physiological and pharmacological manipulations based on cannabinoid receptors, ligands and endocannabinoids have explained some medicinal attributes of cannabinoids as used across the world for thousands of years. Plant-der...

journal_title：Expert review of neurotherapeutics

authors： Holdcroft A,Patel P

更新日期：2001-09-01 00:00:00

abstract：:Seizures are often the presenting symptoms of a cerebral tumor and may precede its diagnosis by many years. The article under evaluation searched two large English registries for patients admitted for new-onset epilepsy. The risk of subsequently being diagnosed with a malignant brain tumor was found to be 26-fold high...

journal_title：Expert review of neurotherapeutics

authors： Schucht P,Duffau H

更新日期：2011-08-01 00:00:00

abstract：:Introduction: Chronic Tic Disorders and Tourette's Disorder (collectively referred to as TD) are characterized by sudden, rapid, and repetitive motor movements or vocalizations called tics. Children, adolescents, and adults with TD often experience co-occurring psychiatric symptoms and impairments in multiple domains....

journal_title：Expert review of neurotherapeutics

authors： Essoe JK,Grados MA,Singer HS,Myers NS,McGuire JF

更新日期：2019-11-01 00:00:00

abstract：:Background: Relatively little is known about the use of disease-modifying drugs (DMDs) for multiple sclerosis (MS) in the population-based universal healthcare setting. This study aimed to describe the characteristics of a population-based cohort with MS and their DMD exposure in four Canadian provinces. Methods: We i...

journal_title：Expert review of neurotherapeutics

authors： Ng HS,Zhu F,Kingwell E,Zhao Y,Yao S,Ekuma O,Svenson LW,Evans C,Fisk JD,Marrie RA,Tremlett H

更新日期：2021-01-01 00:00:00

abstract：:Alzheimer's disease is common, incurable and disabling. It is expected to grow dramatically in prevalence over the next 50 years. At current, the standard of care for patients with mild and moderately severe Alzheimer's disease includes the use of acetylcholinesterase inhibitors. Donepezil (Aricept) is a highly select...

journal_title：Expert review of neurotherapeutics

authors： Geldmacher DS

更新日期：2004-01-01 00:00:00

abstract：:Dysregulation of the mTOR signaling pathway is associated with highly epileptogenic conditions such as tuberous sclerosis, focal cortical dysplasia, hemimegalencephaly and ganglioglioma, grouped under the term of 'mTORopathies'. Brain abnormalities associated with mTOR overactivation include enlarged and dysplastic ne...

journal_title：Expert review of neurotherapeutics

authors： Curatolo P,Moavero R

更新日期：2013-06-01 00:00:00

abstract：:Cognitive behavioral therapy has been found to be efficacious in the treatment of generalized anxiety disorder (GAD). However, reviews of the clinical significance has indicated that approximately 50% of patients with GAD return to a 'well' status following treatment. So how might the field advance? One way is to base...

journal_title：Expert review of neurotherapeutics

authors： Heiden Cv

更新日期：2013-02-01 00:00:00

abstract：:Recent morphometric MRI studies have investigated brain volume abnormalities associated with the diagnosis of Alzheimer's disease (AD) using voxel-based morphometry (VBM). This technique allows the assessment of gray matter volumes in subjects with AD or related conditions compared with healthy controls in an automate...

journal_title：Expert review of neurotherapeutics

authors： Busatto GF,Diniz BS,Zanetti MV

更新日期：2008-11-01 00:00:00

abstract：:The subthalamic nucleus (STN) has been a major target of deep brain stimulation (DBS) for Parkinson's disease (PD) over the past 20 years. The benefits of DBS of the STN include: decreased motor fluctuations and bradykinesia, tremor reduction and a reduction in dopaminergic drug requirements and dyskinesias. Despite t...

journal_title：Expert review of neurotherapeutics

authors： Bari AA,Fasano A,Munhoz RP,Lozano AM

更新日期：2015-10-01 00:00:00

abstract：:Chronic inflammatory demyelinating polyradiculoneuropathy is a neuromuscular disorder for which immunological factors are undoubtedly important in the etiopathogenesis. As clinical recognition of this disorder has improved, immunosuppressive and immunomodulating treatments have emerged as the treatments of choice and ...

journal_title：Expert review of neurotherapeutics

authors： Kaplan RL,Albers JW

更新日期：2003-03-01 00:00:00

abstract：:Acute disseminated encephalomyelitis (ADEM) is traditionally regarded as a monophasic demyelinating disorder of the central nervous system occurring in children after infection or vaccination. ADEM in children has a polysymptomatic presentation that includes encephalopathy, fever and meningeal signs. In adults, enceph...

journal_title：Expert review of neurotherapeutics

authors： Berzero G,Cortese A,Ravaglia S,Marchioni E

更新日期：2016-01-01 00:00:00

abstract：:Pharmacotherapy, psychotherapy and other nonpharmacological interventions are used in patients with major depressive disorder (MDD). However, 50% of the patients with MDD fail to achieve a response to first-line antidepressant treatment. In four of five acute monotherapy studies, once-daily extended-release quetiapine...

journal_title：Expert review of neurotherapeutics

authors： Weisler R,McIntyre RS

更新日期：2013-11-01 00:00:00

abstract：:Poststroke aphasia results from the lesion of cortical areas involved in the motor production of speech (Broca's aphasia) or in the semantic aspects of language comprehension (Wernicke's aphasia). Such lesions produce an important reorganization of speech/language-specific brain networks due to an imbalance between co...

journal_title：Expert review of neurotherapeutics

authors： Mylius V,Zouari HG,Ayache SS,Farhat WH,Lefaucheur JP

更新日期：2012-08-01 00:00:00

abstract：:The risk of recurrent stroke following transient ischemic attack or minor stroke has recently been shown to be 5-10% at 1 week and 10-20% at 3 months, depending on study population and methods. This is considerably higher than previously estimated and current clinical guidelines reflect the need for rapid assessment a...

journal_title：Expert review of neurotherapeutics

authors： Giles MF,Rothwell PM

更新日期：2005-03-01 00:00:00

abstract：:Social anxiety disorder (SAD) is a prevalent, disabling disorder. We aimed to assess the effects of pharmacotherapy for SAD and to determine whether particular classes of medication are more effective and/or better tolerated than others. A systematic review and meta-analysis was conducted of all published and unpublis...

journal_title：Expert review of neurotherapeutics

authors： Ipser JC,Kariuki CM,Stein DJ

更新日期：2008-02-01 00:00:00