The therapeutic potential of renin angiotensin aldosterone system (RAAS) in chronic pain: from preclinical studies to clinical trials.

abstract：:Alterations have been demonstrated in membrane phospholipid metabolism in Alzheimer's disease. Alterations in membrane phospholipid metabolite levels have been observed by 31P magnetic resonance spectroscopy 4 years before onset of cognitive changes. Implications of phospholipid membrane changes in Alzheimer's disease...

journal_title：Expert review of neurotherapeutics

authors： Pettegrew JW,McClure RJ

更新日期：2002-09-01 00:00:00

abstract：:Narcolepsy is a life-long neurodegenerative disorder that causes considerable impairment to quality of life. Until the 1970s, the treatment for one of the main symptoms, excessive daytime sleepiness, was restricted to stimulants, whereas the second core symptom, cataplexy, was treated with antidepressants, and the res...

journal_title：Expert review of neurotherapeutics

authors： Mayer G

更新日期：2012-05-01 00:00:00

abstract：:Introduction: Cognitive impairment and behavioral disturbances are common findings in Parkinson's disease (PD). Despite initially being considered late complications of the disease, it is currently accepted that almost all PD patients will exhibit cognitive and behavioral abnormalities from the early and even the prem...

journal_title：Expert review of neurotherapeutics

authors： Martinez-Horta S,Horta-Barba A,Kulisevsky J

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:Antipsychotics have long been the mainstay of treatment for agitation and psychosis in Alzheimer's disease. Despite their current use successive studies have shown that they only confer a modest benefit which must be balanced against their well-established serious side effects (extrapyramidal symptoms, str...

journal_title：Expert review of neurotherapeutics

authors： Creese B,Da Silva MV,Johar I,Ballard C

更新日期：2018-06-01 00:00:00

abstract：:Many antiepileptic drugs (AEDs) have therapeutic applications that extend beyond epilepsy to include neuropathic pain, migraine headaches and psychiatric disorders. The risk of some AEDs has been clearly established, but for newer drugs, small sample sizes and polytherapy exposures preclude a conclusive determination ...

journal_title：Expert review of neurotherapeutics

authors： Hill DS,Wlodarczyk BJ,Palacios AM,Finnell RH

更新日期：2010-06-01 00:00:00

abstract：:Over the last decade, much progress has been made towards identifying risk factors for schizophrenia. It is now thought that many genes of small effect contribute towards risk of developing schizophrenia and some of these probably confer susceptibility to environmental factors. Large population-based studies, using re...

journal_title：Expert review of neurotherapeutics

authors： Boydell J

更新日期：2001-11-01 00:00:00

abstract：:In 1993, interferon (IFN)-beta(1b) for subcutaneous injection became the first US FDA-approved immunomodulatory treatment for multiple sclerosis, a chronic inflammatory disease of the CNS. In this review of IFN-beta(1b), we first present a short introduction to multiple sclerosis and currently available therapeutics. ...

journal_title：Expert review of neurotherapeutics

authors： Buttmann M,Rieckmann P

更新日期：2007-03-01 00:00:00

abstract：:Generalized cognitive impairments are stable deficits linked to schizophrenia and key factors associated with functional disability in the disorder. Preclinical data suggest that second-generation antipsychotics could potentially reduce cognitive impairments; however, recent large clinical trials indicate only modest ...

journal_title：Expert review of neurotherapeutics

authors： Hill SK,Bishop JR,Palumbo D,Sweeney JA

更新日期：2010-01-01 00:00:00

abstract：:An influence of climate upon cerebrovascular risk is both biologically plausible and supported by epidemiological evidence. These relationships are important as they could yield public health strategies to help protect the vulnerable from the increased death rates arising during extreme cold and heat waves. Change in ...

journal_title：Expert review of neurotherapeutics

authors： McArthur K,Dawson J,Walters M

更新日期：2010-02-01 00:00:00

abstract：:Introduction: Paroxysmal dyskinesias and episodic ataxias are often caused by mutations in genes related to cell membrane and synaptic function. Despite the exponential increase in publications of genetically confirmed cases, management remains largely clinical based on non-systematic evidence. Areas covered: The auth...

journal_title：Expert review of neurotherapeutics

authors： De Gusmao CM,Silveira-Moriyama L

更新日期：2019-09-01 00:00:00

abstract：:Evaluation of: Segal BM, Constantinescu CS, Raychaudhuri A et al. Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a Phase II, double-blind, placebo-controlled, randomized, dose-ranging study. Lancet Neurol. 7, 796-804 (2008). ...

journal_title：Expert review of neurotherapeutics

authors： Longbrake EE,Racke MK

更新日期：2009-03-01 00:00:00

abstract：:Guillain-Barré syndrome (GBS) includes demyelinating and axonal subtypes with different immunopathologic mechanisms. In acute inflammatory demyelinating polyradiculoneuropathy, segmental demyelination and conduction block are the pathological and electrophysiological correlates of muscle weakness. Slowed conductions a...

journal_title：Expert review of neurotherapeutics

authors： Uncini A,Yuki N

更新日期：2009-06-01 00:00:00

abstract：:Schizophrenia is a common, debilitating illness for which treatment is empirical and unsatisfactory. Intense efforts to identify etiological factors have been launched in order to facilitate rational therapy. Such efforts have included gene-mapping studies since a significant heritability has been proved. In common wi...

journal_title：Expert review of neurotherapeutics

authors： Northup A,Nimgaonkar VL

更新日期：2004-07-01 00:00:00

abstract：:Attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) commonly co-occur. With the DSM-5, clinicians are permitted to make an ASD diagnosis in the context of ADHD. In earlier versions of the DSM, this was not acceptable. Both ASD and ADHD are reported to have had substantial increases in pr...

journal_title：Expert review of neurotherapeutics

authors： Antshel KM,Zhang-James Y,Wagner KE,Ledesma A,Faraone SV

更新日期：2016-01-01 00:00:00

abstract：:Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral condition that impairs functioning throughout childhood and adolescence. Evidence-based guidelines for the treatment of ADHD recommend recognizing ADHD as a chronic condition. The chronic care model for child health emphasizes the need for pro...

journal_title：Expert review of neurotherapeutics

authors： Brinkman WB,Epstein JN

更新日期：2011-04-01 00:00:00

abstract：:Epilepsy is the most common serious neurological disorder in the elderly after stroke and dementia. It may be more important for elderly people because it is intermittent and unpredictable. There is no reliable diagnostic test and so its diagnosis and management requires clinical acumen and experience. The situation i...

journal_title：Expert review of neurotherapeutics

authors： Johnston A,Smith PE

更新日期：2010-12-01 00:00:00

abstract：:Poststroke aphasia results from the lesion of cortical areas involved in the motor production of speech (Broca's aphasia) or in the semantic aspects of language comprehension (Wernicke's aphasia). Such lesions produce an important reorganization of speech/language-specific brain networks due to an imbalance between co...

journal_title：Expert review of neurotherapeutics

authors： Mylius V,Zouari HG,Ayache SS,Farhat WH,Lefaucheur JP

更新日期：2012-08-01 00:00:00

abstract：:The subthalamic nucleus (STN) has been a major target of deep brain stimulation (DBS) for Parkinson's disease (PD) over the past 20 years. The benefits of DBS of the STN include: decreased motor fluctuations and bradykinesia, tremor reduction and a reduction in dopaminergic drug requirements and dyskinesias. Despite t...

journal_title：Expert review of neurotherapeutics

authors： Bari AA,Fasano A,Munhoz RP,Lozano AM

更新日期：2015-10-01 00:00:00

abstract：:Malignant gliomas comprise a small percentage of all cancers, but continue to cause disproportionate levels of morbidity and mortality. Despite decades of intensive effort from many disciplines--surgery, radiation oncology and medicine--they remain refractory to cure and, in most cases, even to prolonged treatment res...

journal_title：Expert review of neurotherapeutics

authors： Nicholas MK,Lukas R,Bangalore S

更新日期：2005-11-01 00:00:00

abstract：:The kynurenine pathway has received increasing attention as its connection to inflammation, the immune system and neurological conditions has become more apparent. It is the primary route for tryptophan catabolism in the liver and the starting point for the synthesis of nicotinamide adenine dinucleotide in mammals. Dy...

journal_title：Expert review of neurotherapeutics

authors： Davis I,Liu A

更新日期：2015-01-01 00:00:00

abstract：:Radiation-induced gliomas represent a relatively rare but an extensively published entity in the neuro-oncologic literature. Extensive retrospective cohort data in pediatric populations after therapeutic intracranial radiation show an increased risk in glioma incidence that is both patient age- and radiation dose/volu...

journal_title：Expert review of neurotherapeutics

authors： Prasad G,Haas-Kogan DA

更新日期：2009-10-01 00:00:00

abstract：:Babies born to mothers exposed to antiepileptic drugs (AEDs) are at increased risk for major congenital malformations, cognitive impairment and fetal death. For the millions of women with epilepsy, maintaining the safest drug that will successfully prevent seizures during pregnancy remains a primary consideration. The...

journal_title：Expert review of neurotherapeutics

authors： Tatum WO

更新日期：2006-07-01 00:00:00

abstract：INTRODUCTION:Spinal muscular atrophy (SMA) is an autosomal recessive degenerative neuromuscular disorder characterized by loss of spinal motor neurons leading to muscle weakness. This review article focuses on a novel antisense oligonucleotide treatment, first ever approved for SMA (nusinersen, SpinrazaTM) and describe...

journal_title：Expert review of neurotherapeutics

authors： Chiriboga CA

更新日期：2017-10-01 00:00:00

abstract：:Introduction: Alzheimer's Disease (AD) is a progressive neurodegenerative pathology characterized by the presence of neuritic plaques and neurofibrillary tangles. The most important markers in AD pathology include excessive accumulation of amyloid beta (Aβ42) and phosphorylated tau (P-tau) proteins. One of the possibl...

journal_title：Expert review of neurotherapeutics

authors： Baranowska-Wójcik E,Szwajgier D

更新日期：2020-03-01 00:00:00

abstract：:Pharmacotherapy, psychotherapy and other nonpharmacological interventions are used in patients with major depressive disorder (MDD). However, 50% of the patients with MDD fail to achieve a response to first-line antidepressant treatment. In four of five acute monotherapy studies, once-daily extended-release quetiapine...

journal_title：Expert review of neurotherapeutics

authors： Weisler R,McIntyre RS

更新日期：2013-11-01 00:00:00

abstract：:Divalproex sodium has been widely use for the treatment of bipolar disorder, behavioral control in schizophrenia, seizure and agitation in Alzheimer's disease. With the advent of other mood stabilizers and anticonvulsants, the use of divaplroex sodium has been slightly decreased; however, it has been a major mediation...

journal_title：Expert review of neurotherapeutics

authors： Han C,Shim DS,Lee SJ,Patkar AA,Masand PS,Pae CU

更新日期：2012-02-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disorder characterized by CNS inflammation, demyelination and cellular damage with atrophy. Most patients with MS initially present with a relapsing-remitting course, with periodic episodes of neurologic symptomatology that do not follow a predictable pattern. In order to maint...

journal_title：Expert review of neurotherapeutics

authors： Fox EJ

更新日期：2010-12-01 00:00:00

abstract：:The third part of this in-depth review series on the treatment of multiple sclerosis (MS) with monoclonal antibodies covers the years 2010-2012. The natalizumab section gives a progressive multifocal leukoencephalopathy update, focusing on clinically relevant aspects. Furthermore, it outlines problems around natalizum...

journal_title：Expert review of neurotherapeutics

authors： Deiß A,Brecht I,Haarmann A,Buttmann M

更新日期：2013-03-01 00:00:00

abstract：:In the last two decades clinicians have become increasingly aware of the frequency, importance and functional impact of cognitive dysfunction in multiple sclerosis. There is, however, a dearth of research in this area. In order to further progress in the field of neuropsychological diagnosis it is essential to validat...

journal_title：Expert review of neurotherapeutics

authors： Amato MP,Zipoli V

更新日期：2002-09-01 00:00:00

abstract：:In different study populations, several studies have shown that modest C-reactive protein elevation, in the range of apparently healthy individuals, is a strong predictor of future vascular events. Willcox and colleagues summarize the epidemiological and clinical observations that have led to the enthusiastic suggesti...

journal_title：Expert review of neurotherapeutics

authors： Di Napoli M,Papa F

更新日期：2004-07-01 00:00:00