Abstract:
:Divalproex sodium has been widely use for the treatment of bipolar disorder, behavioral control in schizophrenia, seizure and agitation in Alzheimer's disease. With the advent of other mood stabilizers and anticonvulsants, the use of divaplroex sodium has been slightly decreased; however, it has been a major mediation for the treatment of such medical conditions. Beyond symptomatic effects on such neuropsychiatric conditions, it has also been proposed to hold some neurotoxicity effects, including reversible brain atrophy (which may be a serious complication associated with substantial cognitive decline), although it has shown neuroprotective effects. Common adverse events include sedation, tiredness and gastrointestinal symptoms. According to a recent study, divalproex treatment was associated with accelerated brain volume loss over 1 year, which could possibly lead to greater cognitive impairment. Hence, this article will discuss clinical and further research implications of this study, as well as the potential limitations and significance of the research.
journal_name
Expert Rev Neurotherjournal_title
Expert review of neurotherapeuticsauthors
Han C,Shim DS,Lee SJ,Patkar AA,Masand PS,Pae CUdoi
10.1586/ern.11.194subject
Has Abstractpub_date
2012-02-01 00:00:00pages
155-8issue
2eissn
1473-7175issn
1744-8360journal_volume
12pub_type
评论,杂志文章abstract::Gliomas constitute the most frequent and malignant primary brain tumors. Current standard therapeutic strategies (surgery, radiotherapy and chemotherapeutics, e.g., temozolomide, carmustin or carboplatin) for their treatment are only palliative and survival diagnosis is normally 6-12 months. The development of new the...
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journal_title:Expert review of neurotherapeutics
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pub_type: 杂志文章,评审
doi:10.1080/14737175.2017.1369880
更新日期:2017-10-01 00:00:00
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更新日期:2014-10-01 00:00:00
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更新日期:2011-04-01 00:00:00
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abstract::The saga of harmful administration of levodopa (LD) in the treatment of Parkinson's disease (PD) resulted from outcomes of animal trials and cell culture studies. They were initiated after the clinical observation of onset of motor complications related to the short plasma half-life of the drug in PD patients. This di...
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