Metabolic treatments of migraine.


:Introduction: Most preventive migraine treatments modify the brain's excitation/inhibition balance and/or serotonin metabolism, which likely accounts for their unfavorable adverse effect profile. Novel biological therapies blocking CGRP transmission are effective and better tolerated, but they are expensive and may not influence brain dysfunctions upstream in the pathophysiological cascade of migraine, including premonitory and aura symptoms. Biochemical and clinical studies suggest that there may be another complimentary treatment strategy, the one that targets the underestimated metabolic facet of migraine pathophysiology.Areas covered: After a brief description of the metabolic abnormalities found in migraine patients, we will review and discuss published data on metabolic treatments of migraine. There is evidence that riboflavin and co-enzyme Q10 are effective for the prevention of migraine and quasi devoid of adverse effects. Response rates are close to those of topiramate, propranolol, and CGRP/CGRPrec mAbs. The evidence is weaker for thioctic acid. Dietary and pharmacological strategies inducing ketosis are novel promising approaches for which preliminary trials with favorable outcomes have been published.Expert opinion: Metabolic treatments of migraine constitute an effective, well-tolerated, inexpensive, and evidence-supported therapeutic option for migraine prophylaxis, and may be considered as first treatment line in many patients, including in children and adolescents.


Expert Rev Neurother


Lisicki M,Schoenen J




Has Abstract


2020-03-01 00:00:00












  • The emerging role of psilocybin and MDMA in the treatment of mental illness.

    abstract:INTRODUCTION:Mental illness has a chronic course of illness with a number of clinical manifestations. Affected individuals experience significant functional, emotional, cognitive, and/or behavioral impairments. The growing prevalence of mental illness has been associated with significant social and economic costs. Inde...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章


    authors: Gill H,Gill B,Chen-Li D,El-Halabi S,Rodrigues NB,Cha DS,Lipsitz O,Lee Y,Rosenblat JD,Majeed A,Mansur RB,Nasri F,Ho R,McIntyre RS

    更新日期:2020-12-01 00:00:00

  • Supportive management of patients with brain tumors.

    abstract::Management issues for patients with brain tumors include peritumoral edema, symptomatic seizures, venous thromboembolism, headache, pain, fatigue and neuropsychological complaints. Vasogenic edema is typically ameliorated with the lowest dose possible of corticosteroid. Seizures are managed with attention to additiona...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Daly FN,Schiff D

    更新日期:2007-10-01 00:00:00

  • Safety and clinical effects of EVP-6124 in subjects with Alzheimer's disease currently or previously receiving an acetylcholinesterase inhibitor medication.

    abstract::Alzheimer's disease (AD) is a prevalent and currently incurable brain disease whose impact will continue to rise as the population ages. With limited treatment options, a variety of experimental therapies are currently in clinical trials. EVP-6124 (encenicline) is an α7 nicotinic acetylcholine receptor partial agonist...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Deardorff WJ,Shobassy A,Grossberg GT

    更新日期:2015-01-01 00:00:00

  • Neuromodulation for the treatment of primary headache syndromes.

    abstract:INTRODUCTION:Neuromodulation techniques play an increasing role in the treatment of primary headaches. While initially reserved for refractory cases they are now increasingly taken into consideration in earlier treatment phases and in non-refractory situations. One of the main reasons for this paradigm shift is that mo...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Hoffmann J,May A

    更新日期:2019-03-01 00:00:00

  • Promoting productive interactions between parents and physicians in the treatment of children with attention-deficit/hyperactivity disorder.

    abstract::Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral condition that impairs functioning throughout childhood and adolescence. Evidence-based guidelines for the treatment of ADHD recommend recognizing ADHD as a chronic condition. The chronic care model for child health emphasizes the need for pro...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Brinkman WB,Epstein JN

    更新日期:2011-04-01 00:00:00

  • Inflammatory and neuroendocrine biomarkers of prognosis after ischemic stroke.

    abstract::Stroke is the third leading cause of mortality in the USA and one of the leading causes of severe morbidity. It is important to provide stroke patients and physicians with the most accurate prognostic information to optimize care and allocation of healthcare resources. Reliable prognostic markers available during the ...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Katan M,Elkind MS

    更新日期:2011-02-01 00:00:00

  • Intensive voice treatment in Parkinson's disease: Lee Silverman Voice Treatment.

    abstract::Advances in neuroscience have led to an expanded and improved understanding of neurobiological changes associated with rehabilitation and exercise in Parkinson's disease (PD). This knowledge has led to a direct clinical impact of increased referral for early and continuous exercise programs for individuals with PD (ph...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Sapir S,Ramig LO,Fox CM

    更新日期:2011-06-01 00:00:00

  • Electrophysiologic and immunopathologic correlates in Guillain-Barré syndrome subtypes.

    abstract::Guillain-Barré syndrome (GBS) includes demyelinating and axonal subtypes with different immunopathologic mechanisms. In acute inflammatory demyelinating polyradiculoneuropathy, segmental demyelination and conduction block are the pathological and electrophysiological correlates of muscle weakness. Slowed conductions a...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Uncini A,Yuki N

    更新日期:2009-06-01 00:00:00

  • Improving outcomes of subthalamic nucleus deep brain stimulation in Parkinson's disease.

    abstract::The subthalamic nucleus (STN) has been a major target of deep brain stimulation (DBS) for Parkinson's disease (PD) over the past 20 years. The benefits of DBS of the STN include: decreased motor fluctuations and bradykinesia, tremor reduction and a reduction in dopaminergic drug requirements and dyskinesias. Despite t...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Bari AA,Fasano A,Munhoz RP,Lozano AM

    更新日期:2015-10-01 00:00:00

  • Rufinamide: a new antiepileptic drug treatment for Lennox-Gastaut syndrome.

    abstract::Lennox-Gastaut syndrome is a relatively rare epilepsy syndrome that usually begins in early-mid childhood and is characterized by multiple seizure types, particularly generalized seizures, which are often resistant to antiepileptic drug medication. Rufinamide is a new antiepileptic drug approved as adjunctive therapy ...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Ferrie CD

    更新日期:2010-06-01 00:00:00

  • Acute ischemic stroke management: concepts and controversies.A narrative review.

    abstract:INTRODUCTION:Amongst the 25.7 million survivors and 6.5 million deaths from stroke between 1990 and 2013, ischemic strokes accounted for approximately 70% and 50% of the cases, respectively. With patients still suffering from complications and stroke recurrence, more questions have been raised as to how we can better i...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章


    authors: Li KHC,Jesuthasan A,Kui C,Davies R,Tse G,Lip GYH

    更新日期:2021-01-01 00:00:00

  • Disease-specific therapy of idiopathic inflammatory demyelinating disorders.

    abstract::Central nervous system idiopathic inflammatory demyelinating disorders are a heterogenous group of diseases that share inflammation and demyelination as key features. Although the exact pathophysiology remains to be fully unveiled, these conditions are challenging to clinicians who seek specific therapeutic options fo...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Khoshnam M,Freedman MS

    更新日期:2012-09-01 00:00:00

  • Cognitive and behavioral assessment in Parkinson's disease.

    abstract::Introduction: Cognitive impairment and behavioral disturbances are common findings in Parkinson's disease (PD). Despite initially being considered late complications of the disease, it is currently accepted that almost all PD patients will exhibit cognitive and behavioral abnormalities from the early and even the prem...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Martinez-Horta S,Horta-Barba A,Kulisevsky J

    更新日期:2019-07-01 00:00:00

  • Lessons learned in the abuse of pain-relief medication: a focus on healthcare costs.

    abstract::The increasing prevalence of chronic pain with its major societal impact and the escalating use of opioids in managing it, along with their misuse, abuse, associated fatalities and costs, are epidemics in modern medicine. Over the past two decades, multiple lessons have been learned addressing various issues of abuse....

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    pub_type: 杂志文章,评审


    authors: Manchikanti L,Boswell MV,Hirsch JA

    更新日期:2013-05-01 00:00:00

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    abstract::In 1993, interferon (IFN)-beta(1b) for subcutaneous injection became the first US FDA-approved immunomodulatory treatment for multiple sclerosis, a chronic inflammatory disease of the CNS. In this review of IFN-beta(1b), we first present a short introduction to multiple sclerosis and currently available therapeutics. ...

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    pub_type: 杂志文章,评审


    authors: Buttmann M,Rieckmann P

    更新日期:2007-03-01 00:00:00

  • Managing bipolar disorder during pregnancy and the postpartum period: a critical review of current practice.

    abstract::Introduction: Despite increased interest in the pharmacotherapy of bipolar disorder during pregnancy and the postpartum period, management of the disorder during these critical periods in a woman's life remains challenging.Areas covered: The authors review the effect of pregnancy and the postpartum period on the cours...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章


    authors: Sharma V,Sharma P,Sharma S

    更新日期:2020-04-01 00:00:00

  • Association of chronic divalproex sodium use and brain atrophy in Alzheimer's disease.

    abstract::Divalproex sodium has been widely use for the treatment of bipolar disorder, behavioral control in schizophrenia, seizure and agitation in Alzheimer's disease. With the advent of other mood stabilizers and anticonvulsants, the use of divaplroex sodium has been slightly decreased; however, it has been a major mediation...

    journal_title:Expert review of neurotherapeutics

    pub_type: 评论,杂志文章


    authors: Han C,Shim DS,Lee SJ,Patkar AA,Masand PS,Pae CU

    更新日期:2012-02-01 00:00:00

  • Role of homocysteine in the treatment of Parkinson's disease.

    abstract::The saga of harmful administration of levodopa (LD) in the treatment of Parkinson's disease (PD) resulted from outcomes of animal trials and cell culture studies. They were initiated after the clinical observation of onset of motor complications related to the short plasma half-life of the drug in PD patients. This di...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Müller T

    更新日期:2008-06-01 00:00:00

  • Comparing treatment options for chronic inflammatory neuropathies and choosing the right treatment plan.

    abstract:INTRODUCTION:Chronic inflammatory neuropathies are disorders caused by an immune response to peripheral nerve. They include chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and neuropathy associated with anti-MAG IgM monoclonal gammopathy and other less frequent neurop...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Nobile-Orazio E,Gallia F,Terenghi F,Bianco M

    更新日期:2017-08-01 00:00:00

  • An update on the comorbidity of ADHD and ASD: a focus on clinical management.

    abstract::Attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) commonly co-occur. With the DSM-5, clinicians are permitted to make an ASD diagnosis in the context of ADHD. In earlier versions of the DSM, this was not acceptable. Both ASD and ADHD are reported to have had substantial increases in pr...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章


    authors: Antshel KM,Zhang-James Y,Wagner KE,Ledesma A,Faraone SV

    更新日期:2016-01-01 00:00:00

  • Update on therapies for cluster headache.

    abstract::Cluster headache is one of the primary headache disorders. It is considered the most severe headache syndrome known to humans. In most instances, this disorder is readily treatable when the correct medications are utilized at the correct dosages. Cluster headache treatment involves abortive, transitional and preventiv...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章


    authors: Rozen TD

    更新日期:2002-05-01 00:00:00

  • Effect of acute and chronic alcohol abuse on pain management in a trauma center.

    abstract::The proper management of acute pain has been identified as a primary indicator of quality assurance in US trauma centers. Nearly half of all trauma patients are injured while intoxicated and 75% of these patients have chronic alcohol problems. The management of pain caused by injuries in patients with alcohol problems...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Askay SW,Bombardier CH,Patterson DR

    更新日期:2009-02-01 00:00:00

  • Fear reduction in patients with chronic pain: a learning theory perspective.

    abstract::Acute pain informs the individual that there is an imminent threat of body damage, and is associated with the urge to escape and avoid. Fear learning takes place when neutral stimuli receive the propensity to predict the occurrence of pain, and when defensive responses are initiated in anticipation of potential threat...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: den Hollander M,de Jong JR,Volders S,Goossens ME,Smeets RJ,Vlaeyen JW

    更新日期:2010-11-01 00:00:00

  • Teratogenic effects of antiepileptic drugs.

    abstract::Many antiepileptic drugs (AEDs) have therapeutic applications that extend beyond epilepsy to include neuropathic pain, migraine headaches and psychiatric disorders. The risk of some AEDs has been clearly established, but for newer drugs, small sample sizes and polytherapy exposures preclude a conclusive determination ...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Hill DS,Wlodarczyk BJ,Palacios AM,Finnell RH

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  • The role of electroencephalogram in neonatal seizure detection.

    abstract:INTRODUCTION:The role of EEG in neonatal seizure detection is well-established, being the multichannel video-EEG the gold standard. However, in the clinical practice often amplitude integrated EEG (aEEG) is used, in order to overcome the difficulties related to EEG use. Areas covered: An overview regarding neonatal sei...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Pisani F,Pavlidis E

    更新日期:2018-02-01 00:00:00

  • Hypothalamic-pituitary-adrenocortical system dysregulation and new treatment strategies in depression.

    abstract::According to the corticoid receptor hypothesis of depression, hyperactivity of the hypothalamic-pituitary-adrenocortical (HPA) system is one of the major pathophysiological factors for the development of depression and opens a broad range of new antidepressant treatment options that are related to direct interventions...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章


    authors: Schüle C,Baghai TC,Eser D,Rupprecht R

    更新日期:2009-07-01 00:00:00

  • The impact of receptor-receptor interactions in heteroreceptor complexes on brain plasticity.

    abstract::Allosteric mechanisms in receptor heteromers markedly increase the repertoire of receptor recognition and signaling. Of high importance is the altered function in the receptor heteromer versus the receptor homomer. Such a change in receptor function is mainly brought about by agonist induced allosteric receptor-recept...

    journal_title:Expert review of neurotherapeutics

    pub_type: 社论


    authors: Fuxe K,Agnati LF,Borroto-Escuela DO

    更新日期:2014-07-01 00:00:00

  • Cluster headache mechanism and treatment.

    abstract::There have been remarkable strides in the last decade in unraveling the mystery of primary headache disorders, such as migraine and cluster headache. The vascular theory has been superseded by the neurovascular phenomena which seems to be the permissive triggering factor in migraine and cluster headache. This has been...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章


    authors: Aurora S

    更新日期:2003-09-01 00:00:00

  • Alemtuzumab in the treatment of relapsing-remitting multiple sclerosis.

    abstract::Multiple sclerosis (MS) is an autoimmune disorder characterized by CNS inflammation, demyelination and cellular damage with atrophy. Most patients with MS initially present with a relapsing-remitting course, with periodic episodes of neurologic symptomatology that do not follow a predictable pattern. In order to maint...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章,评审


    authors: Fox EJ

    更新日期:2010-12-01 00:00:00

  • Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia.

    abstract::Introduction: Tardive dyskinesia (TD) is a hyperkinetic movement disorder that arises as a complication of exposure to dopamine receptor blocking agents. Vesicular monoamine transporter type 2 (VMAT2) inhibitors reduce dyskinesia by decreasing transport of monoamines, including dopamine, into presynaptic vesicles, lea...

    journal_title:Expert review of neurotherapeutics

    pub_type: 杂志文章


    authors: Dorfman BJ,Jimenez-Shahed J

    更新日期:2021-01-01 00:00:00