Abstract:
:Endometriosis is a complex disease that is influenced by genetic and environmental factors. In endometriosis, WNT4 plays a likely role owing to its biological functions. In this study, the TaqMan allelic discrimination technique was used to investigate the relationship between endometriosis and four single nucleotide polymorphisms in WNT4 (rs7521902 [A/C], rs16826658 [G/T], rs7515106 [C/T] and rs2235529 [A/G]) in Chinese Han women. A total of 646 patients with endometriosis and 766 normal controls were recurited. Regression analyses revealed that rs2235529 was a risk locus for endometriosis (P = 1.80E-03, OR, 95% CI = 1.311, 1.129 to 1.522), particularly in patients with stage III and IV disease. No significant association was found between endometriosis and rs7521902 (A/C), rs16826658 (G/T), or rs7515106 (C/T). For each of the four single nucleotide polymorphisms, no association was found between patients with endometriosis-related infertility or primary infertility and the controls. The results demonstrated that WNT4 rs2235529 is associated with endometriosis in Chinese Han women, which may result in aberrant expression of WNT4, leading to the pathogenesis of endometriosis.
journal_name
Reprod Biomed Onlinejournal_title
Reproductive biomedicine onlineauthors
Wu Z,Yuan M,Li Y,Fu F,Ma W,Li H,Wang W,Wang Sdoi
10.1016/j.rbmo.2014.12.010subject
Has Abstractpub_date
2015-04-01 00:00:00pages
415-20issue
4eissn
1472-6483issn
1472-6491pii
S1472-6483(15)00003-6journal_volume
30pub_type
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journal_title:Reproductive biomedicine online
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pub_type: 临床试验,杂志文章
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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