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Effect of maternal and paternal age on pregnancy and miscarriage rates after intrauterine insemination.

Abstract：

:More than 17,000 intrauterine insemination (lUI) cycles were analysed retrospectively with respect to outcome according to differing aetiologies of infertility. The quantity and motility of spermatozoa in the final preparation used for insemination had a positive effect on the outcome, as classically observed in the past. It was found that advanced maternal age had a negative effect on the pregnancy rate and was associated with increased miscarriage rate. More interestingly, an exactly parallel effect was found for paternal age. The impact of increased age on necrospermia and sperm DNA structure is discussed as a probable direct cause of this paternal effect.

journal_name

Reprod Biomed Online

journal_title

Reproductive biomedicine online

authors

Belloc S,Cohen-Bacrie P,Benkhalifa M,Cohen-Bacrie M,De Mouzon J,Hazout A,Ménézo Y

doi

10.1016/s1472-6483(10)60223-4

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

392-7

issue

3

eissn

1472-6483

issn

1472-6491

pii

S1472-6483(10)60223-4

journal_volume

17

pub_type

杂志文章

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