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Vacuoles in sperm head are not associated with head morphology, DNA damage and reproductive success.

Abstract：

:In this retrospective study of 873 men enrolled for assisted reproduction techniques, relationships between sperm quality parameters, motile sperm organelle morphology examination (MSOME), DNA damage and live birth rate were evaluated. The presence of vacuoles in the sperm heads was detected by MSOME. Either chromatin decondensation or DNA fragmentation was used to study DNA damage. Results show that age significantly affected some of the examined parameters. In particular, sperm concentration was positively correlated (R = 0.088; P = 0.01) and chromatin decondensation was negatively correlated (R = -0.102; P = 0.003) with age. Furthermore, live birth rate was significantly lower in men aged 40 years or older (P < 0.02) compared with the younger age groups. The presence of sperm head vacuoles was not associated with head morphology, main sperm quality parameters, DNA fragmentation and live birth rate. Considering sperm heads in relation to the shape (normal/abnormal) and vacuoles (presence/absence), no significant variations in the occurrence of vacuoles in either normal or abnormal heads were found. These data suggest that vacuoles are physiological features that do not alter sperm functionality, and it seems that MSOME is not necessary for increasing the success of assisted reproduction techniques.

journal_name

Reprod Biomed Online

journal_title

Reproductive biomedicine online

authors

Fortunato A,Boni R,Leo R,Nacchia G,Liguori F,Casale S,Bonassisa P,Tosti E

doi

10.1016/j.rbmo.2015.10.009

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

154-61

issue

2

eissn

1472-6483

issn

1472-6491

pii

S1472-6483(15)00540-4

journal_volume

32

pub_type

杂志文章

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