当前位置： SCI文献检索 > REPRODUCTIVE BIOMEDICINE ONLINE期刊下所有文献 > N-acetylcysteine improves function and follicular survival in mice ovarian grafts through inhibition of oxidative stress.

N-acetylcysteine improves function and follicular survival in mice ovarian grafts through inhibition of oxidative stress.

Abstract：

:The effect of N-acetylcysteine (NAC) on mouse ovary heterotopic autotransplantation was investigated. Mice (age 4-5 weeks) were divided into the following groups: control; autograft plus NAC (150 mg/kg daily intraperitoneal injection) and autograft plus saline (n = 6 per group). Groups were treated from 1 day before until 7 days after transplantation. After 28 days, ovary compartments were estimated stereologically. Plasma malondialdehyde, progesterone, oestradiol concentrations and the percentage of apoptotic follicles were measured to evaluate the rate of oxidative stress and ovarian graft function. The mean total volume of ovary, cortex and the number of follicles was significantly higher (all P < 0.001) in the autografts plus NAC group compared with the saline group. In the autografts plus NAC group, the mean percentage of apoptotic follicles (P < 0.001) and malondialdehyde concentration (P < 0.001 day 7; P < 0.05 day 28) were significantly lower, whereas oestradiol concentration was significantly higher (P < 0.05) compared with the saline group. Although NAC cannot compensate the above parameters to the control level, it considerably improves follicular survival and development and also the structure and function of transplanted ovaries, through reducing oxidative stress and apoptosis.

journal_name

Reprod Biomed Online

journal_title

Reproductive biomedicine online

authors

Mahmoodi M,Soleimani Mehranjani M,Shariatzadeh SM,Eimani H,Shahverdi A

doi

10.1016/j.rbmo.2014.09.013

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

101-10

issue

1

eissn

1472-6483

issn

1472-6491

pii

S1472-6483(14)00534-3

journal_volume

30

pub_type

杂志文章

相关文献

REPRODUCTIVE BIOMEDICINE ONLINE文献大全
  • Freeze-thaw programmes rescue the implantation of day 6 blastocysts.

    abstract：:The developmental rate of a blastocyst is considered one of the main estimates for evaluating the implantation potential of embryos. Day 6 blastocysts have been reported to be much less viable than day 5 blastocysts. Regarding implantation, the implantation window is advanced due to a background of high sex hormones, ...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/s1472-6483(10)61134-0

    authors： Murata Y,Oku H,Morimoto Y,Tokuda M,Murata T,Sugihara K,Nagata F,Nakaoka Y,Fukuda A

    更新日期：2005-10-01 00:00:00

  • PGD for X-linked and gender-dependent disorders using a robust, flexible single-tube PCR protocol.

    abstract：:X-linked genetic diseases include a wide range of disorders such as the dystrophinopathies. Additionally in some rare genetic diseases, severity of expression is gender dependent. Prevention of such disorders usually involves prenatal diagnosis and termination of affected pregnancies, while preimplantation genetic dia...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/s1472-6483(10)60178-2

    authors： Christofidou C,Sofocleous C,Vrettou C,Destouni A,Traeger-Synodinos J,Kekou K,Palmer G,Kokkali G,Mavrou A,Kitsiou S,Kanavakis E

    更新日期：2009-09-01 00:00:00

  • Anti-Müllerian hormone in pregnant women in relation to other hormones, fetal sex and in circulation of second trimester fetuses.

    abstract：:The aim of this study was to investigate the regulation of anti-Müllerian hormone (AMH) blood concentrations in mother and fetus during pregnancy. Serum concentrations of AMH, gonadotrophins, oestradiol and progesterone were measured in pregnant women in the first trimester and AMH concentrations in second-trimester f...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/s1472-6483(10)60016-8

    authors： Lutterodt M,Byskov AG,Skouby SO,Tabor A,Yding Andersen C

    更新日期：2009-05-01 00:00:00

  • Moral attitudes and beliefs among couples pursuing PGD for sex selection.

    abstract：:This article reports the results from a study of couples participating in a research protocol in which IVF/preimplantation genetic diagnosis (PGD) was available for non-medical sex selection. The study sought to characterize the moral attitudes and beliefs of couples actively pursuing IVF/PGD solely for purposes relat...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/j.rbmo.2010.09.009

    authors： Sharp RR,McGowan ML,Verma JA,Landy DC,McAdoo S,Carson SA,Simpson JL,McCullough LB

    更新日期：2010-12-01 00:00:00

  • Effect of uterine dimensions on live birth rates after single embryo transfer in infertile women.

    abstract：RESEARCH QUESTION:Do uterine size parameters measured by baseline transvaginal ultrasound predict live birth after single embryo transfer (SET) of a high-quality blastocyst? DESIGN:Retrospective cohort study including women undergoing their first SET between August 2010 and March 2014 at a large university hospital re...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/j.rbmo.2020.07.007

    authors： Steiner N,Ates S,Shaulov T,Tannus S,Dahan MH

    更新日期：2020-10-01 00:00:00

  • Predictors of reproductive outcomes following myomectomy for intramural fibroids.

    abstract：RESEARCH QUESTION:Which factors are associated with reproductive outcomes among infertile women undergoing myomectomy for intramural fibroids? DESIGN:This was a historical cohort study including 127 infertile women who underwent myomectomy due to intramural fibroids as part of fertility enhancement treatment at a sing...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/j.rbmo.2019.04.130

    authors： Lebovitz O,Orvieto R,James KE,Styer AK,Brown DN

    更新日期：2019-09-01 00:00:00

  • A preliminary report of successful cleavage after calcium ionophore activation at ICSI in cases with previous arrest at the pronuclear stage.

    abstract：:Artificial oocyte activation (AOA) has been previously suggested as a means to overcome the problem of total fertilization failure, which affects about 1-3% of the intracytoplasmic sperm injection (ICSI) cycles. A preliminary study on the application of chemical AOA was conducted using A23187 Ca(2+) ionophore to impro...

    journal_title：Reproductive biomedicine online

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.rbmo.2015.08.012

    authors： Darwish E,Magdi Y

    更新日期：2015-12-01 00:00:00

  • Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development.

    abstract：:Developmental toxicity caused by exposure to a mixture of environmental pollutants has become a major health concern. Human-made chemicals, including xenoestrogens, pesticides and heavy metals, as well as unhealthy lifestyle behaviours, mainly tobacco smoking, alcohol consumption and medical drug abuse, are major fact...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章,评审

    doi：10.1016/j.rbmo.2014.03.002

    authors： Al-Gubory KH

    更新日期：2014-07-01 00:00:00

  • Intrauterine pregnancy following transperitoneal oocyte and/or sperm migration in a woman with an ectopic (undescended) ovary.

    abstract：:This is the first report of an intrauterine pregnancy following timed coitus, resulting from transperitoneal sperm and/or oocyte migration as the oocyte originated from an ectopic (undescended) ovary. The patient was treated in the infertility clinic after a history of primary infertility for 2 years. Diagnosis of a m...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/s1472-6483(10)61738-5

    authors： Ombelet W,Deblaere K,Grieten M,Verswijvel G,Nijs M,Hinoul P,de Jonge E

    更新日期：2003-07-01 00:00:00

  • CYP1A1, GSTM1 and GSTT1 genetic polymorphism is associated with susceptibility to polycystic ovaries in South Indian women.

    abstract：:Polymorphic variants in the phase I enzyme, cytochrome P450 gene, may lead to increased toxification, whereas polymorphisms in the phase II enzyme, glutathione S-transferase genes, may result in impaired detoxification. Alterations in the activities of phase I drug metabolizing enzymes and phase II detoxification enzy...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/s1472-6483(10)62129-3

    authors： Babu KA,Rao KL,Kanakavalli MK,Suryanarayana VV,Deenadayal M,Singh L

    更新日期：2004-08-01 00:00:00

  • Effect of FSH and its different isoforms on maturation of oocytes from pre-ovulatory follicles.

    abstract：:FSH exists as a family of isohormones exhibiting distinct oligosaccharide structures, and the released FSH isoform mixtures change during the follicular phase of the menstrual cycle. In addition, the pulsatile release of gonadotrophins seems to expose follicles to bursts of more less-acidic FSH isoforms and the follic...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章,评审

    doi：10.1016/s1472-6483(10)61826-3

    authors： Yding Andersen C

    更新日期：2002-11-01 00:00:00

  • Are synechiae a complication of laparotomic myomectomy?

    abstract：:Laparotomic myomectomy is often the only realistic solution for symptomatic women with multiple or large myomas who wish to retain their fertility. The aim of this study was to document the rate of uterine synechiae and their associated risk factors after laparotomic myomectomy. This prospective observational study to...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/j.rbmo.2018.01.010

    authors： Capmas P,Pourcelot AG,Fernandez H

    更新日期：2018-04-01 00:00:00

  • Mid-luteal progesterone concentrations are associated with live birth rates during ovulation induction.

    abstract：:This retrospective study investigated whether mid-luteal serum progesterone concentrations are associated with live birth rates in women with WHO group II anovulatory infertility undergoing ovulation induction. Data were from women (n=335) stimulated with gonadotrophins using a low-dose step-up protocol, of which wome...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/j.rbmo.2011.01.006

    authors： Arce JC,Balen A,Platteau P,Pettersson G,Andersen AN

    更新日期：2011-05-01 00:00:00

  • Inositol supplementation in women with polycystic ovary syndrome undergoing intracytoplasmic sperm injection: a systematic review and meta-analysis of randomized controlled trials.

    abstract：:Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disease that involves menstrual dysfunction and reproductive difficulty, as well as metabolic problems. The aim of this study was to assess the effectiveness of myo-inositol (MYO) and d-chiro-inositol (DCI) on improving oocyte or embryo quality and pregna...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.rbmo.2017.07.005

    authors： Mendoza N,Pérez L,Simoncini T,Genazzani A

    更新日期：2017-11-01 00:00:00

  • Annexin A5 haplotype M2 is not a risk factor for recurrent spontaneous abortion in Northern Europe: is there sufficient evidence?

    abstract：:The M2 haplotype of the annexin A5 gene is a well-recognized predisposition factor for recurrent spontaneous abortion (RSA). A recent publication by Nagirnaja et al. (2015) in PLoS One discusses the risk role of the M2 haplotype for RSA in cases compared with controls of North European extraction and arrives at a nega...

    journal_title：Reproductive biomedicine online

    pub_type： 评论,杂志文章

    doi：10.1016/j.rbmo.2016.02.004

    authors： Markoff A,Kurahashi H,Grandone E,Bogdanova N

    更新日期：2016-05-01 00:00:00

  • Efficiency of assisted oocyte activation as a solution for failed intracytoplasmic sperm injection.

    abstract：:Failed fertilization after intracytoplasmic sperm injection (ICSI) can occur due to an oocyte activation defect. In these cases assisted oocyte activation (AOA) may help but efficiency is still unknown. Prior to AOA, the mouse oocyte activation test (MOAT) can be carried out by injecting human spermatozoa into mouse o...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/s1472-6483(10)60313-6

    authors： Heindryckx B,De Gheselle S,Gerris J,Dhont M,De Sutter P

    更新日期：2008-11-01 00:00:00

  • Very early prenatal diagnosis on coelomic cells using quantitative fluorescent polymerase chain reaction.

    abstract：:Quantitative fluorescent PCR (QF-PCR) has been shown to be an accurate assay for the rapid prenatal diagnosis of chromosome disorders. The extra-embryonic coelom develops during week 4 of gestation and it can be aspirated from the following week, making coelocentesis the earliest possible method of prenatal diagnosis ...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/s1472-6483(10)62173-6

    authors： Jauniaux E,Cirigliano V,Adinolfi M

    更新日期：2003-06-01 00:00:00

  • Artificial oocyte activation: evidence for clinical readiness.

    abstract：:Artificial oocyte activation using Ca(2+)ionophores or similar compounds is a widely applied technique in IVF laboratories. This is all the more interesting as most of the agents aiming for intracellular Ca(2+) increase do not result in physiological Ca(2+) oscillations but much rather cause a single Ca(2+) transient....

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/j.rbmo.2015.12.004

    authors： Ebner T,Montag M

    更新日期：2016-03-01 00:00:00

  • Immunoregulation in normal pregnancy and pre-eclampsia: an overview.

    abstract：:Pre-eclampsia is a major disorder of human pregnancy, which may have an immunological basis. It is a disease of two stages. The first stage concerns the relative failure of early trophoblast invasion and remodelling of the spiral arteries, leading to a poor blood supply to the placenta, exposing it to oxidative stress...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章,评审

    doi：10.1016/s1472-6483(10)60659-1

    authors： Sargent IL,Borzychowski AM,Redman CW

    更新日期：2006-11-01 00:00:00

  • Counselling considerations for chromosomal mosaicism detected by preimplantation genetic screening.

    abstract：:The evolution of preimplantation genetic screening (PGS) for aneuploidy to blastocyst biopsy and more sensitive 24-chromosome screening techniques has resulted in a new diagnostic category of PGS results: those classified as mosaic. This diagnosis presents significant challenges for clinicians in developing policies r...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/j.rbmo.2017.01.003

    authors： Besser AG,Mounts EL

    更新日期：2017-04-01 00:00:00

  • Effects of cigarette smoke exposure on pregnancy outcome and offspring of diabetic rats.

    abstract：:A total of 52 female Wistar rats were distributed into four groups: non-diabetic (G1) and diabetic (G2) exposed to filtered air; non-diabetic (G3) and diabetic (G4) exposed to cigarette smoke. Diabetes was induced by streptozotocin (40 mg/kg bodyweight, i.v.). Rats were exposed, for 30 min, to filtered air (control) o...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/s1472-6483(10)60135-6

    authors： de Souza Mda S,Lima PH,Sinzato YK,Rudge MV,Pereira OC,Damasceno DC

    更新日期：2009-04-01 00:00:00

  • Pregnancy outcome after multifetal pregnancy reduction of triplets to twins versus reduction to singletons.

    abstract：RESEARCH QUESTION:Does fetal reduction of triplet pregnancies to singleton result in superior obstetric and neonatal outcomes compared with triplets reduced to twins? DESIGN:A historical cohort study including 285 trichorionic and dichorionic triplet pregnancies that underwent abdominal fetal reduction at 11-14 weeks ...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/j.rbmo.2019.12.014

    authors： Zemet R,Haas J,Bart Y,Barzilay E,Zloto K,Argaman N,Schwartz N,Weisz B,Yinon Y,Mazaki-Tovi S,Lipitz S

    更新日期：2020-03-01 00:00:00

  • The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment.

    abstract：:Sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo quality and pregnancy rates, and higher rates of spontaneous miscarriage and childhood diseases. This review provides a synopsis of the most ...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章,评审

    doi：10.1016/j.rbmo.2013.06.014

    authors： Lewis SE,John Aitken R,Conner SJ,Iuliis GD,Evenson DP,Henkel R,Giwercman A,Gharagozloo P

    更新日期：2013-10-01 00:00:00

  • Cost-effectiveness of ovarian stimulation with gonadotrophin and clomiphene citrate in an intrauterine insemination programme for subfertile couples.

    abstract：:Ovarian stimulation with low-dose human menopausal gonadotrophin (HMG) is superior to clomiphene citrate in intrauterine insemination (IUI) cycles with respect to clinical pregnancy rate, but it is unclear whether HMG is also the more cost-effective option. The aim of this study was to compare the cost-effectiveness o...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/j.rbmo.2017.12.007

    authors： Peeraer K,Luyten J,Tomassetti C,Verschueren S,Spiessens C,Tanghe A,Meuleman C,Debrock S,Dancet E,D'Hooghe T

    更新日期：2018-03-01 00:00:00

  • Is the dimension of ovarian endometriomas significantly modified by IVF-ICSI cycles?

    abstract：:Information regarding the growth and development of endometriomas during IVF-intracytoplasmic sperm injection (ICSI) cycles is lacking. In this study, the aim was to estimate the influence of IVF-ICSI on the dimension of these cysts and to assess whether this treatment contributes to the manifestation of new endometri...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/s1472-6483(10)60099-5

    authors： Benaglia L,Somigliana E,Vighi V,Nicolosi AE,Iemmello R,Ragni G

    更新日期：2009-03-01 00:00:00

  • Supplementation of clomiphene citrate cycles with Cimicifuga racemosa or ethinyl oestradiol--a randomized trial.

    abstract：:The anti-oestrogenic activity of clomiphene citrate (CC) on the cervical mucous and endometrium may be the reason for the relatively low pregnancy rates in CC induction cycles. Various follicular-phase supplements have been tried to improve cycle outcome in these patients. This study compared follicular-phase suppleme...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.rbmo.2009.06.007

    authors： Shahin AY,Ismail AM,Shaaban OM

    更新日期：2009-10-01 00:00:00

  • Evolution of embryo selection for IVF from subjective morphology assessment to objective time-lapse algorithms improves chance of live birth.

    abstract：RESEARCH QUESTION:Does using an objective time-lapse imaging algorithm (TLIA) after IVF relate to conventional morphological assessment of human blastocysts as a prognosticator for live birth? DESIGN:Prospective use of a TLIA to select embryos in multicentre IVF clinics all using the same strictly controlled laborator...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/j.rbmo.2019.10.005

    authors： Fishel S,Campbell A,Foad F,Davies L,Best L,Davis N,Smith R,Duffy S,Wheat S,Montgomery S,Wachter A,Beccles A

    更新日期：2020-01-01 00:00:00

  • Follicle stimulating hormone or clomiphene citrate in intrauterine insemination with ovarian stimulation for unexplained subfertility: a role for treatment selection markers?

    abstract：RESEARCH QUESTION:Can women be identified, on the basis of baseline patient characteristics, as having better chances of an ongoing pregnancy with FSH instead of clomiphene citrate as stimulation agent in intrauterine insemination for unexplained subfertility? DESIGN:A secondary analysis of a multicentre randomized co...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.rbmo.2019.01.014

    authors： Danhof NA,van Eekelen R,Repping S,Mol BWJ,van der Veen F,van Wely M,Mochtar MH,SUPER Study group.

    更新日期：2019-06-01 00:00:00

  • Are morphokinetic parameters of embryo development associated with adverse perinatal outcomes following fresh blastocyst transfer?

    abstract：RESEARCH QUESTION:Are obstetric and perinatal complications associated with morphokinetic parameters of embryo development? DESIGN:This proof-of-concept pilot study included a retrospective analysis of embryo morphokinetic parameters of 85 live births following day 5 single blastocyst transfer. Kinetic variables inclu...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章

    doi：10.1016/j.rbmo.2020.09.030

    authors： Doron-Lalehzari A,Wainstock T,Szaingurten-Solodkin I,Richter D,Zeadna A,Harlev A,Lunenfeld E,Levitas E,Har-Vardi I

    更新日期：2021-01-01 00:00:00

  • Underlying karyotype abnormalities in IVF/ICSI patients.

    abstract：:Cytogenetic investigations are performed in couples asking for IVF or intracytoplasmic sperm injection (ICSI) treatment. These serve a diagnostic purpose because male or female infertility might have a chromosomal origin. Chromosomal aberrations found in these patients include numerical abnormalities, such as Klinefel...

    journal_title：Reproductive biomedicine online

    pub_type： 杂志文章,评审

    doi：10.1016/s1472-6483(10)60458-0

    authors： Chantot-Bastaraud S,Ravel C,Siffroi JP

    更新日期：2008-04-01 00:00:00