Abstract:
:FSH exists as a family of isohormones exhibiting distinct oligosaccharide structures, and the released FSH isoform mixtures change during the follicular phase of the menstrual cycle. In addition, the pulsatile release of gonadotrophins seems to expose follicles to bursts of more less-acidic FSH isoforms and the follicle is likely to be exposed to an almost ever changing composition of FSH isoforms. The different isoforms causes a number of different and divergent biological effects. FSH promotes oocyte maturation, and 5-10 IU/l of less-acidic FSH isoforms are sufficient to induce oocyte maturation in vitro. Exposure of cumulus-oocyte complexes to less-acidic FSH isoforms in a pulse-like fashion results in a rapid pattern of cAMP accumulation exceeding that seen with acidic isoforms, which appear to sustain lower but more constant cAMP production. The presence of particularly less-acidic isoforms for a period exceeding 30 min causes an attenuated cAMP response. In conclusion, it appears that pulsatile and intermittent release of less-acidic/short-living FSH isoforms is sufficient to induce biological responses, while allowing the granulosa cells to regain responsiveness to further FSH stimulation. Together with the interpulse release of more acidic isoforms, overall FSH secretion seems to ensure proper follicular maturation resulting in the release of developmentally competent oocytes.
journal_name
Reprod Biomed Onlinejournal_title
Reproductive biomedicine onlineauthors
Yding Andersen Cdoi
10.1016/s1472-6483(10)61826-3keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
232-9issue
3eissn
1472-6483issn
1472-6491pii
S1472-6483(10)61826-3journal_volume
5pub_type
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
pub_type: 评论,杂志文章
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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更新日期:2005-02-01 00:00:00
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journal_title:Reproductive biomedicine online
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更新日期:2010-10-01 00:00:00
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章,评审
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章
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journal_title:Reproductive biomedicine online
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更新日期:2009-03-01 00:00:00
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章,随机对照试验
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更新日期:2008-12-01 00:00:00
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journal_title:Reproductive biomedicine online
pub_type: 临床试验,杂志文章
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更新日期:2015-12-01 00:00:00
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rbmo.2009.06.007
更新日期:2009-10-01 00:00:00
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journal_title:Reproductive biomedicine online
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更新日期:2019-11-01 00:00:00
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章
doi:10.1016/j.rbmo.2010.06.020
更新日期:2010-11-01 00:00:00