Abstract：
:As a member of the homeobox (HOX) gene family, HOXA11 is expressed in the primordia of lower uterus and cervix during fetal life and is essential for endometrial development and embryo implantation in the adults. The aim of the present study was to investigate whether mutations in HOXA11 contribute to Müllerian duct anomalies (MDA) in Chinese. A cohort of 192 patients with MDA and 192 healthy controls was enrolled. Genomic DNA was extracted. All exons and exon-intron boundaries were amplified and sequenced. One novel synonymous variant (c.774G>A) and one known single-nucleotide polymorphism were identified, both of which were not found in the matched controls. The results suggest that mutations in the coding region of HOXA11 are not common in Chinese women with MDA. As a member of the homeobox gene family, HOXA11 is expressed in the primordia of lower uterus and cervix during fetal life and is essential for endometrial development and embryo implantation in the adults. The aim of the present study was to investigate whether mutations in HOXA11 contribute to Müllerian duct anomalies (MDA) in Chinese. A cohort of 192 patients with MDA and 192 healthy controls was enrolled. Genomic DNA was extracted. All exons and exon-intron boundaries were amplified and sequenced. One novel synonymous variant (c.774G>A) and one known single-nucleotide polymorphism were identified, both of which were not found in the matched controls. The results suggest that mutations in the coding region of HOXA11 are not common in Chinese women with MDA.
journal_name
Reprod Biomed Onlinejournal_title
Reproductive biomedicine onlineauthors
Chen X,Li G,Qin Y,Cui Y,You L,Chen ZJdoi
10.1016/j.rbmo.2014.01.018subject
Has Abstractpub_date
2014-06-01 00:00:00pages
739-42issue
6eissn
1472-6483issn
1472-6491pii
S1472-6483(14)00075-3journal_volume
28pub_type
杂志文章abstract：:Recent advances in assisted reproduction treatment have enabled some couples with severe infertility issues to conceive, but the methods are not successful in all cases. Notwithstanding the significant financial burden of assisted reproduction treatment, the emotional scars from an inability to conceive a child enacts...
journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
pub_type： 杂志文章,随机对照试验
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journal_title：Reproductive biomedicine online
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更新日期：2018-04-01 00:00:00
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journal_title：Reproductive biomedicine online
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更新日期：2008-02-01 00:00:00
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journal_title：Reproductive biomedicine online
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doi：10.1016/j.rbmo.2011.01.006
更新日期：2011-05-01 00:00:00
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journal_title：Reproductive biomedicine online
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doi：10.1016/s1472-6483(10)60599-8
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journal_title：Reproductive biomedicine online
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doi：10.1016/s1472-6483(10)60506-8
更新日期：2004-01-01 00:00:00
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journal_title：Reproductive biomedicine online
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doi：10.1016/j.rbmo.2018.05.008
更新日期：2018-08-01 00:00:00
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
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更新日期：2010-12-01 00:00:00
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journal_title：Reproductive biomedicine online
pub_type： 杂志文章,评审
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journal_title：Reproductive biomedicine online
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journal_title：Reproductive biomedicine online
pub_type： 杂志文章,随机对照试验
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更新日期：2008-12-01 00:00:00
abstract：:Total fertilization failures (TFF) are rare events of IVF by intracytoplasmic sperm injection (ICSI). When male factor is excluded, the lack of identifiable aetiological criteria raises the question of the reliable clinical management. The goal of this study was to identify molecular abnormalities in metaphase II (MII...
journal_title：Reproductive biomedicine online
pub_type： 杂志文章
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更新日期：2008-12-01 00:00:00
abstract：:Different gonadotrophin preparations derived from human urine or manufactured by recombinant technology are currently used in clinical practice for the treatment of infertility. It has been widely assumed that gonadotrophin products manufactured by recombinant technology have better batch-to-batch consistency compared...
journal_title：Reproductive biomedicine online
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更新日期：2005-04-01 00:00:00
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journal_title：Reproductive biomedicine online
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更新日期：2011-02-01 00:00:00
abstract：:It remains controversial whether anti-Müllerian hormone (AMH) concentration is influenced by hormonal contraception. This study quantified the effect of hormonal contraception on both endocrine and sonographic ovarian reserve markers in 228 users and 504 non-users of hormonal contraception. On day 2-5 of the menstrual...
journal_title：Reproductive biomedicine online
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更新日期：2012-12-01 00:00:00
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journal_title：Reproductive biomedicine online
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更新日期：2017-11-01 00:00:00
abstract：:It has been suggested that during the past five decades human sperm counts have declined and the incidence of testicular cancer, hypospadias and cryptorchidism has increased. Furthermore, geographical differences, with respect to these markers of male reproductive function, have been reported. According to a recent hy...
journal_title：Reproductive biomedicine online
pub_type： 杂志文章,评审
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更新日期：2007-12-01 00:00:00
abstract：:The effect of N-acetylcysteine (NAC) on mouse ovary heterotopic autotransplantation was investigated. Mice (age 4-5 weeks) were divided into the following groups: control; autograft plus NAC (150 mg/kg daily intraperitoneal injection) and autograft plus saline (n = 6 per group). Groups were treated from 1 day before u...
journal_title：Reproductive biomedicine online
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
abstract：:Endometrial receptivity is a prerequisite for blastocyst implantation. During receptivity, the hairy-like epithelial cell microvilli transiently fuse to a single flower-like membrane projection called the 'pinopode'. Scanning electron microscopy in sequential endometrial biopsies shows that pinopodes appear about 1 we...
journal_title：Reproductive biomedicine online
pub_type： 杂志文章,评审
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