Abstract:
:High daily doses of gonadotrophin-releasing hormone (GnRH) antagonists during the follicular phase of ovarian stimulation were associated with low implantation rates. To test if this occurred because of profound pituitary suppression, the pituitary response was suppressed with a high-dose GnRH antagonist and recombinant LH (rLH) was added back to correct the implantation rate. An open-label, randomized, controlled, prospective clinical study in 60 patients undergoing IVF was performed. GnRH antagonist was initiated on day 6 of stimulation (2 mg/day) together with 375 IU rLH, and maintained until the day of HCG administration. Controls received 0.25 mg/day GnRH antagonist. Fluctuating LH concentrations were present on days 3 and 6 in both groups. This strong fluctuation continued on day 8 and on the day of HCG administration in the control (low-dose) group, where 30% of patients had LH concentrations <1 IU/1 on the HCG day. The study (high-dose) group showed stable LH concentrations on day 8 and on the HCG day, with no LH surges. No clinical differences were found between groups. The LH add-back strategy (375 IU/day) rescued the adverse effects that high doses of GnRH imposed on implantation. These results suggest that rLH should be considered during ovarian stimulation with GnRH antagonist.
journal_name
Reprod Biomed Onlinejournal_title
Reproductive biomedicine onlineauthors
Garcia-Velasco JA,Bennink HJ,Epifanio R,Escudero E,Pellicer A,Simón Cdoi
10.1016/S1472-6483(11)60009-6subject
Has Abstractpub_date
2011-02-01 00:00:00pages
S52-9eissn
1472-6483issn
1472-6491pii
S1472-6483(11)60009-6journal_volume
22 Suppl 1pub_type
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