Abstract:
:The expression of fibroblast growth factor 10 (FGF-10) has not been studied in human ovarian cortical follicles. The aim of the present study was to investigate the expression of FGF-10 in preantral follicles from fetuses, girls and women. Ovarian samples were obtained from 14 human fetuses at 21-33 gestational weeks and from 35 girls and women aged 5-39 years. The specimens were prepared for detection of the FGF-10 protein by immunohistochemistry. Reverse-transcription PCR was applied to ovarian extracts to identify FGF-10 mRNA transcripts. In fetal tissue, the FGF-10 protein was detected in oocytes in 50% of the samples and in granulosa cells in 30%. In ovarian tissue from girls and women, the FGF-10 protein was detected in oocytes and granulosa cells in all samples. FGF-10 mRNA transcripts were present in all adult and fetal samples tested. The identification of FGF-10 at both the protein and mRNA levels suggests that FGF-10 may contribute to human preantral follicle development.
journal_name
Reprod Biomed Onlinejournal_title
Reproductive biomedicine onlineauthors
Oron G,Fisch B,Zhang XY,Gabbay-Benziv R,Kessler-Icekson G,Krissi H,Ben-Haroush A,Ao A,Abir Rdoi
10.1016/j.rbmo.2012.07.002subject
Has Abstractpub_date
2012-10-01 00:00:00pages
396-401issue
4eissn
1472-6483issn
1472-6491pii
S1472-6483(12)00415-4journal_volume
25pub_type
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