Abstract:
RESEARCH QUESTION:What is the cost-effectiveness of gonadotrophins compared with clomiphene citrate in couples with unexplained subfertility undergoing intrauterine insemination (IUI) with ovarian stimulation under strict cancellation criteria? DESIGN:A cost-effectiveness analysis alongside a randomized controlled trial (RCT). Between July 2013 and March 2016, 738 couples were randomized to gonadotrophins (369) or clomiphene citrate (369) in a multicentre RCT in the Netherlands. The direct medical costs of both strategies were compared. Direct medical costs included costs of medication, cycle monitoring, insemination and, if applicable, pregnancy monitoring. Non-parametric bootstrap resampling was used to investigate the effect of uncertainty in estimates. The cost-effectiveness analysis was performed according to intention-to-treat. The incremental cost-effectiveness ratio (ICER) between gonadotrophins and clomiphene citrate for ongoing pregnancy and live birth was assessed. RESULTS:The mean costs per couple were €1534 for gonadotrophins and €1067 for clomiphene citrate (mean difference of €468; 95% confidence interval [CI] €464-472). As ongoing pregnancy rates were 31% in women allocated to gonadotrophins and 26% in women allocated to clomiphene citrate (relative risk 1.16, 95% CI 0.93-1.47), the ICER was €21,804 (95% CI €11,628-31,980) per additional ongoing pregnancy with gonadotrophins and €17,044 (95% CI €8998-25,090) per additional live birth with gonadotrophins. CONCLUSIONS:Gonadotrophins are more expensive compared with clomiphene citrate in couples with unexplained subfertility undergoing IUI with adherence to strict cancellation criteria, without being significantly more effective.
journal_name
Reprod Biomed Onlinejournal_title
Reproductive biomedicine onlineauthors
Danhof NA,van Wely M,Repping S,van der Ham DP,Klijn N,Janssen ICAH,Rijn-van Weert JM,Twisk M,Traas MAF,Pelinck MJ,Perquin DAM,Boks DES,Sluijmer A,Mol BWJ,van der Veen F,Mochtar MH,Amsterdam SUPER Study Group.doi
10.1016/j.rbmo.2019.09.004subject
Has Abstractpub_date
2020-01-01 00:00:00pages
99-104issue
1eissn
1472-6483issn
1472-6491pii
S1472-6483(19)30740-0journal_volume
40pub_type
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journal_title:Reproductive biomedicine online
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