Abstract:
:Progesterone has been implicated in the process of spermatogenesis. This study aimed to investigate the association of progesterone receptor (PR) expression with spermatogenesis in the testis of infertile men. PR mRNA and protein were assessed by in-situ hybridization and immunohistochemistry in testicular biopsies obtained from 18 infertile men. The extent of spermatogenesis was assessed by Johnsen scoring. None of the patients included in the study had Yq microdeletions. PR expression was almost undetectable in all the testicular sections displaying Sertoli cell only (SCO) or arrest at spermatogonia. Weak cytoplasmic expression was observed in biopsies showing arrest at different stages of meiosis. In biopsies displaying spermatogenesis up to the round spermatid stages, PR expression was observed in both nucleus and cytoplasm of different cell types at intensity lower than that detected in normal biopsies. Normal PR expression was observed in biopsies demonstrating hypospermatogenesis. In biopsies showing mixed phenotypes, the tubules with SCO or spermatogonia arrest showed absence of PR expression; normal PR expression was observed in adjacent tubules showing complete spermatogenesis. Semi-quantitative assessment of PR expression and Johnsen scores in the testicular biopsies of infertile men demonstrating different phenotypes indicated a direct relationship between PR expression and extent of spermatogenesis.
journal_name
Reprod Biomed Onlinejournal_title
Reproductive biomedicine onlineauthors
Abid S,Gokral J,Maitra A,Meherji P,Kadam S,Pires E,Modi Ddoi
10.1016/s1472-6483(10)60192-7subject
Has Abstractpub_date
2008-08-01 00:00:00pages
175-84issue
2eissn
1472-6483issn
1472-6491pii
S1472-6483(10)60192-7journal_volume
17pub_type
杂志文章abstract::Implantation requires highly orchestrated interactions between the developing embryo and maternal endometrium. The association between abnormal implantation and reproductive failure is evident, both in normal pregnancy and in assisted reproduction patients. Failure of implantation is the pregnancy rate-limiting step i...
journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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更新日期:2007-01-01 00:00:00
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章,随机对照试验
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章,评审
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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pub_type: 杂志文章
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章,meta分析
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章,评审
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章
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