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Annexin A5 haplotype M2 is not a risk factor for recurrent spontaneous abortion in Northern Europe: is there sufficient evidence?

Abstract：

:The M2 haplotype of the annexin A5 gene is a well-recognized predisposition factor for recurrent spontaneous abortion (RSA). A recent publication by Nagirnaja et al. (2015) in PLoS One discusses the risk role of the M2 haplotype for RSA in cases compared with controls of North European extraction and arrives at a negative result. As a number of previous and fairly recent studies have supported the proposed involvement of the M2 haplotype in the cause of idiopathic RSA, this commentary aims to highlight problematic issues in the above publication. It is the opinion of the authors that the study by Nagirnaja et al. (2015) does not generate adequate proof of the absence of RSA risk, attributable to carriage of the M2 haplotype.

journal_name

Reprod Biomed Online

journal_title

Reproductive biomedicine online

authors

Markoff A,Kurahashi H,Grandone E,Bogdanova N

doi

10.1016/j.rbmo.2016.02.004

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

469-73

issue

5

eissn

1472-6483

issn

1472-6491

pii

S1472-6483(16)00054-7

journal_volume

32

pub_type

评论,杂志文章

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