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Are morphokinetic parameters of embryo development associated with adverse perinatal outcomes following fresh blastocyst transfer?

Abstract：

RESEARCH QUESTION:Are obstetric and perinatal complications associated with morphokinetic parameters of embryo development? DESIGN:This proof-of-concept pilot study included a retrospective analysis of embryo morphokinetic parameters of 85 live births following day 5 single blastocyst transfer. Kinetic variables included time interval (hours) from time of pronuclei fading (tPNf) to: time of 2 cells (tPNf-t2), 9 cells (tPNf-t9), morula (tPNf-tM), start of blastulation (tPNf-tSB), full blastocyst (tPNf-tB) and expanded blastocyst (tPNf-tEB). Multivariable logistic models were used to calculate the risk of perinatal complications after adjustment for confounders. RESULTS:The mean interval of tPNf-tSB was significantly longer for newborns with congenital anomalies compared with healthy newborns (79.49 ± 5.78 versus 71.7 ± 6.3, respectively, P = 0.01) and for embryos of women who had gestational diabetes mellitus compared with normoglycemic women (76.56 ± 7.55 versus 71.5 ± 6.13, respectively, P = 0.015). The mean interval of tPNf-t9 was significantly longer for low-birthweight newborns compared with normal weight (49.25 ± 5.54 versus 45.47 ± 4.77, respectively, P = 0.01). Preterm delivery was associated with several longer intervals of cell divisions compared with delivery at term (tPNf-t5: 28.76 ± 3.13 versus 26.64 ± 2.40, respectively, P = 0.01; tPNf-t6: 30.10 ± 3.05 versus 27.68 ± 2.30, respectively, P < 0.001; tPNf-t7: 32.08 ± 4.11 versus 28.70 ± 2.67, respectively, P < 0.001; tPNf-t8: 34.75 ± 4.95 versus 30.70 ± 4.10, respectively, P < 0.001; tPNf-t9: 50.23 ± 5.87 versus 45.44 ± 4.67, respectively, P < 0.001). For each of the outcomes, the association remained significant after adjusting for confounders. CONCLUSION:This study indicates that there may be a possible association between adverse perinatal outcomes and morphokinetic parameters. Larger studies are needed to establish this association.

journal_name

Reprod Biomed Online

journal_title

Reproductive biomedicine online

authors

Doron-Lalehzari A,Wainstock T,Szaingurten-Solodkin I,Richter D,Zeadna A,Harlev A,Lunenfeld E,Levitas E,Har-Vardi I

doi

10.1016/j.rbmo.2020.09.030

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

207-216

issue

eissn

1472-6483

issn

1472-6491

pii

S1472-6483(20)30535-6

journal_volume

pub_type

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Are morphokinetic parameters of embryo development associated with adverse perinatal outcomes following fresh blastocyst transfer?